Search Results - "Brezovjakova, Helena"
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Junction Mapper is a novel computer vision tool to decipher cell-cell contact phenotypes
Published in eLife (03-12-2019)“…Stable cell-cell contacts underpin tissue architecture and organization. Quantification of junctions of mammalian epithelia requires laborious manual…”
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Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization
Published in The Journal of cell biology (07-06-2021)“…Rac1 GTPase is hyperactivated in tumors and contributes to malignancy. Rac1 disruption of junctions requires its effector PAK1, but the precise mechanisms are…”
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Journal Article -
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Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma
Published in Science translational medicine (29-05-2024)“…T cell-based cancer immunotherapy has typically relied on membrane-bound cytotoxicity enhancers such as chimeric antigen receptors expressed in autologous αβ T…”
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Journal Article