Search Results - "Brewer, Kimberly D"

Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis by Ye, Deju, Shuhendler, Adam J, Pandit, Prachi, Brewer, Kimberly D, Tee, Sui Seng, Cui, Lina, Tikhomirov, Grigory, Rutt, Brian, Rao, Jianghong

“…Non-invasive detection of caspase-3/7 activity has provided invaluable predictive information regarding tumor therapeutic efficacy and anti-tumor drug…”
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Molecular Magnetic Resonance Imaging of Tumor Response to Therapy by Shuhendler, Adam J., Ye, Deju, Brewer, Kimberly D., Bazalova-Carter, Magdalena, Lee, Kyung-Hyun, Kempen, Paul, Dane Wittrup, K., Graves, Edward E., Rutt, Brian, Rao, Jianghong

“…Personalized cancer medicine requires measurement of therapeutic efficacy as early as possible, which is optimally achieved by three-dimensional imaging given…”
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NEMA NU 1-2018 performance characterization and Monte Carlo model validation of the Cubresa Spark SiPM-based preclinical SPECT scanner by Strugari, Matthew E., DeBay, Drew R., Beyea, Steven D., Brewer, Kimberly D.

“…Background The Cubresa Spark is a novel benchtop silicon-photomultiplier (SiPM)-based preclinical SPECT system. SiPMs in SPECT significantly improve resolution…”
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Unique depot formed by an oil based vaccine facilitates active antigen uptake and provides effective tumour control by Brewer, Kimberly D, Weir, Genevieve M, Dude, Iulia, Davis, Christa, Parsons, Cathryn, Penwell, Andrea, Rajagopalan, Rajkannan, Sammatur, Leeladhar, Bowen, Chris V, Stanford, Marianne M

“…Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is…”
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Quantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapy by Tremblay, Marie-Laurence, O'Brien-Moran, Zoe, Rioux, James A., Nuschke, Andrea, Davis, Christa, Kast, W. Martin, Weir, Genevieve, Stanford, Marianne, Brewer, Kimberly D.

“…DPX is a unique T cell activating formulation that generates robust immune responses (both clinically and preclinically) which can be tailored to various…”
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Characterization of Magneto-Endosymbionts as MRI Cell Labeling and Tracking Agents by Brewer, Kimberly D., Spitler, Ryan, Lee, Kayla R., Chan, Andrea C., Barrozo, Joyce C., Wakeel, Abdul, Foote, Chandler S., Machtaler, Steven, Rioux, James, Willmann, Juergen K., Chakraborty, Papia, Rice, Bradley W., Contag, Christopher H., Bell, Caleb B., Rutt, Brian K.

“…Purpose Magneto-endosymbionts (MEs) show promise as living magnetic resonance imaging (MRI) contrast agents for in vivo cell tracking. Here we characterize the…”
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Asymmetric spin-echo (ASE) spiral improves BOLD fMRI in inhomogeneous regions by Brewer, Kimberly D., Rioux, James A., D'Arcy, Ryan C. N., Bowen, Chris V., Beyea, Steven D.

“…Functional MRI (fMRI) is of limited use in areas such as the orbitofrontal and inferior temporal lobes due to the presence of local susceptibility‐induced…”
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Using MRI to evaluate and predict therapeutic success from depot-based cancer vaccines by DeBay, Drew R, Brewer, Kimberly D, LeBlanc, Sarah A, Weir, Genevieve M, Stanford, Marianne M, Mansour, Marc, Bowen, Chris V

“…In the preclinical development of immunotherapy candidates, understanding the mechanism of action and determining biomarkers that accurately characterize the…”
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Using MRI cell tracking to monitor immune cell recruitment in response to a peptide‐based cancer vaccine by Tremblay, Marie‐Laurence, Davis, Christa, Bowen, Chris V., Stanley, Olivia, Parsons, Cathryn, Weir, Genevieve, Karkada, Mohan, Stanford, Marianne M., Brewer, Kimberly D.

“…Purpose MRI cell tracking can be used to monitor immune cells involved in the immunotherapy response, providing insight into the mechanism of action, temporal…”
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Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction by Parker, Ellen, Aboghazleh, Refat, Mumby, Griffin, Veksler, Ronel, Ofer, Jonathan, Newton, Jillian, Smith, Rylan, Kamintsky, Lyna, Jones, Casey M A, O'Keeffe, Eoin, Kelly, Eoin, Doelle, Klara, Roach, Isabelle, Yang, Lynn T, Moradi, Pooyan, Lin, Jessica M, Gleason, Allison J, Atkinson, Christina, Bowen, Chris, Brewer, Kimberly D, Doherty, Colin P, Campbell, Matthew, Clarke, David B, van Hameren, Gerben, Kaufer, Daniela, Friedman, Alon

“…The mechanisms underlying the complications of mild traumatic brain injury, including post-concussion syndrome, post-impact catastrophic death, and delayed…”
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Functional mapping in the corpus callosum: A 4 T fMRI study of white matter by Gawryluk, Jodie R, D'Arcy, Ryan CN, Mazerolle, Erin L, Brewer, Kimberly D, Beyea, Steven D

“…The idea of fMRI activation in white matter (WM) is controversial. Our recent work has used two different approaches to investigate whether there is evidence…”
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Confirming white matter fMRI activation in the corpus callosum: Co-localization with DTI tractography by Mazerolle, Erin L., Beyea, Steven D., Gawryluk, Jodie R., Brewer, Kimberly D., Bowen, Chris V., D'Arcy, Ryan C.N.

“…Recently, functional magnetic resonance imaging (fMRI) activation has been detected in white matter, despite the widely-held belief that fMRI activation is…”
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Clearance of depot vaccine SPIO-labeled antigen and substrate visualized using MRI by Brewer, Kimberly D, Lake, Kerry, Pelot, Nicole, Stanford, Marianne M, DeBay, Drew R, Penwell, Andrea, Weir, Genevieve M, Karkada, Mohan, Mansour, Marc, Bowen, Chris V

“…Highlights • Vaccine components were visualized longitudinally when tagged with iron oxide. • In vivo changes in biodistribution observed using magnetic…”
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Functional mapping in the corpus callosum: A 4T fMRI study of white matter by Gawryluk, Jodie R., D'Arcy, Ryan C.N., Mazerolle, Erin L., Brewer, Kimberly D., Beyea, Steven D.

“…The idea of fMRI activation in white matter (WM) is controversial. Our recent work has used two different approaches to investigate whether there is evidence…”
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Optimizing the detection of white matter fMRI using asymmetric spin echo spiral by Gawryluk, Jodie R., Brewer, Kimberly D., Beyea, Steven D., D'Arcy, Ryan C.N.

“…The majority of functional magnetic resonance imaging (fMRI) studies restrict their focus to gray matter regions because this tissue is highly perfused…”
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Quantification of superparamagnetic iron oxide with large dynamic range using TurboSPI by Rioux, James A., Brewer, Kimberly D., Beyea, Steven D., Bowen, Chris V.

“…[Display omitted] ► High temporal resolution relaxation rate mapping with single-point imaging. ► Automatic calibration aligns stimulated echoes to improve…”
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Signal displacement in spiral-in acquisitions: simulations and implications for imaging in SFG regions by Brewer, Kimberly D, Rioux, James A, Klassen, Martyn, Bowen, Chris V, Beyea, Steven D

“…Abstract Susceptibility field gradients (SFGs) cause problems for functional magnetic resonance imaging (fMRI) in regions like the orbital frontal lobes,…”
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Using lymph node swelling as a potential biomarker for successful vaccination by Brewer, Kimberly D, DeBay, Drew R, Dude, Iulia, Davis, Christa, Lake, Kerry, Parsons, Cathryn, Rajagopalan, Rajkannan, Weir, Genevieve, Stanford, Marianne M, Mansour, Marc, Bowen, Chris V

“…There is currently a lack of biomarkers to help properly assess novel immunotherapies at both the preclinical and clinical stages of development. Recent work…”
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Using lymph node swelling as a potential biomarker for successful vaccination by Brewer, Kimberly D., DeBay, Drew R., Dude, Iulia, Davis, Christa, Lake, Kerry, Parsons, Cathryn, Rajagopalan, Rajkannan, Weir, Genevieve, Stanford, Marianne M., Mansour, Marc, Bowen, Chris V.

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Swallowers (Chiasmodontidae, Scombriformes) of The Gully Marine Protected Area, in the northwest Atlantic by Kenchington, Trevor J., Brewer, Kimberly D., Strugari, Matthew E., Ehler, Hannah J. S., Kenchington, Ellen L.

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