Search Results - "Brewer, Fred C."

Effects of Clustered Epitopes in Multivalent Ligand−Receptor Interactions by Dam, Tarun K, Brewer, C. Fred

“…Many biological ligands are composed of clustered binding epitopes. However, the effects of clustered epitopes on the affinity of ligand−receptor interactions…”
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Density-dependent Lectin–Glycan Interactions as a Paradigm for Conditional Regulation by Posttranslational Modifications by Dennis, James W., Brewer, C. Fred

“…Mice with null mutations in specific Golgi glycosyltransferases show evidence of glycan compensation where missing carbohydrate epitopes are found on…”
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Thermodynamics of Multivalent Carbohydrate−Lectin Cross-Linking Interactions: Importance of Entropy in the Bind and Jump Mechanism by Dam, Tarun K, Gerken, Thomas A, Brewer, C. Fred

“…The high affinity (K d = 0.2 nM) of the soybean agglutinin (SBA), a tetrameric GalNAc specific lectin, for a modified form of porcine submaxillary mucin, a…”
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Thermodynamic Studies of Lectin−Carbohydrate Interactions by Isothermal Titration Calorimetry by Dam, Tarun K, Brewer, C. Fred

“…Dam and Brewer present a comprehensive review of thermodynamic data in the literature for lectin-carbohydrate interactions over the past decade. ITC-derived…”
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Galectin-3 Precipitates as a Pentamer with Synthetic Multivalent Carbohydrates and Forms Heterogeneous Cross-linked Complexes by Ahmad, Nisar, Gabius, Hans-J., André, Sabine, Kaltner, Herbert, Sabesan, Subramanian, Roy, René, Liu, Bingcan, Macaluso, Frank, Brewer, C. Fred

“…Galectin-3 is unique among the galectin family of animal lectins in its biological activities and structure. Most members of the galectin family including…”
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Binding and cross-linking properties of galectins by Fred Brewer, C

“…The galectins are a family of animal lectins that possess similar carbohydrate binding specificities and conserved consensus sequences. The biological…”
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Maintenance of cell surface glycan density by lectin-glycan interactions: A homeostatic and innate immune regulatory mechanism by Dam, Tarun K, Brewer, Fred C

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Isothermal Titration Calorimetry Reveals Differential Binding Thermodynamics of Variable Region-identical Antibodies Differing in Constant Region for a Univalent Ligand by Dam, Tarun K., Torres, Marcela, Brewer, C. Fred, Casadevall, Arturo

“…The classical view of immunoglobulin molecules posits two functional domains defined by the variable (V) and constant (C) regions, which are responsible for…”
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Enhanced Self-Association of Mucins Possessing the T and Tn Carbohydrate Cancer Antigens at the Single-Molecule Level by Haugstad, Kristin E., Gerken, Thomas A., Stokke, Bjørn T., Dam, Tarun K., Brewer, C. Fred, Sletmoen, Marit

“…Mucins are linear O-glycosylated glycoproteins involved in inflammation, cell adhesion, and tumorigenesis. Cancer-associated mucins often possess increased…”
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Lectins as pattern recognition molecules: The effects of epitope density in innate immunity by Dam, Tarun K, Brewer, C. Fred

“…The innate immune response of multicellular organisms is initiated by the binding of soluble and membrane-bound host molecules including lectins to the surface…”
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Thermodynamic, Kinetic, and Electron Microscopy Studies of Concanavalin A and Dioclea grandiflora Lectin Cross-linked with Synthetic Divalent Carbohydrates by Dam, Tarun K., Oscarson, Stefan, Roy, René, Das, Sanjoy K., Pagé, Daniel, Macaluso, Frank, Brewer, C. Fred

“…The jack bean lectin concanavalin A (ConA) and the Dioclea grandiflora lectin (DGL) are highly homologous Man/Glc-specific members of the Diocleinae subtribe…”
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Thermodynamic binding studies of galectin-1, -3 and -7 by Brewer, C Fred

“…The carbohydrate binding specificities of the galectin family of animal lectins has been the source of intense recent investigations. Isothermal titration…”
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Thermodynamic Binding Parameters of Individual Epitopes of Multivalent Carbohydrates to Concanavalin A As Determined by “Reverse” Isothermal Titration Microcalorimetry by Dam, Tarun K, Roy, René, Pagé, Daniel, Brewer, C. Fred

“…The preceding paper [Dam, T. K., Roy, R., Pagé, D., and Brewer, C. F. (2002) Biochemistry 41, 1351−1358] demonstrated that Hill plots of isothermal titration…”
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Mechanism of Mucin Recognition by Lectins: A Thermodynamic Study by Dam, Tarun K, Edwards, Jared L, Kadav, Priyanka D, Brewer, C Fred

“…Isothermal titration microcalorimetry (ITC) can directly determine the thermodynamic binding parameters of biological molecules including affinity constant,…”
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Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate–carbohydrate interactions by Sletmoen, Marit, Gerken, Thomas A, Stokke, Bjørn T, Burchell, Joy, Brewer, C Fred

“…Abstract The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the…”
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Galectin-3 and Galectin-1 Bind Distinct Cell Surface Glycoprotein Receptors to Induce T Cell Death by Stillman, Brianna N, Hsu, Daniel K, Pang, Mabel, Brewer, C. Fred, Johnson, Pauline, Liu, Fu-Tong, Baum, Linda G

“…Galectins are a family of mammalian beta-galactoside-binding proteins that positively and negatively regulate T cell death. Extracellular galectin-1 directly…”
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Multivalent Lectin-Carbohydrate Interactions: Energetics and Mechanisms of Binding by Dam, Tarun K, Brewer, C Fred

“…The biological signaling properties of lectins, which are carbohydrate-binding proteins, are due to their ability to bind and cross-link multivalent…”
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Clusters, bundles, arrays and lattices: novel mechanisms for lectin–saccharide-mediated cellular interactions by Brewer, C.Fred, Miceli, M.Carrie, Baum, Linda G

“…Multivalent protein–carbohydrate interactions regulate essential cellular events, including cell proliferation, adhesion and death. These multivalent…”
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Probing lectin-mucin interactions by isothermal titration microcalorimetry by Dam, Tarun K, Brewer, C Fred

“…Isothermal titration microcalorimetry (ITC) can directly determine the thermodynamic binding parameters of biological molecules including affinity constant,…”
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Galectins Bind to the Multivalent Glycoprotein Asialofetuin with Enhanced Affinities and a Gradient of Decreasing Binding Constants by Dam, Tarun K, Gabius, Hans-J, André, Sabine, Kaltner, Herbert, Lensch, Martin, Brewer, C. Fred

“…Our previous isothermal titration microcalorimetry (ITC) studies of the binding of synthetic multivalent carbohydrates to the Man/Glc-specific lectins…”
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