Search Results - "Brewer, Abigail"

Somatic and anxiety-like behaviors in male and female rats during withdrawal from the non-selective cannabinoid agonist WIN 55,212–2 by Brewer, Abigail L., Felter, Claire E., Sternitzky, Anna R., Spencer, Sade M.

“…Synthetic cannabinoids are associated with higher risk of dependence and more intense withdrawal symptoms than plant-derived Δ9-tetrahydrocannabinol (THC)…”
Get full text

Modeling spontaneous opioid withdrawal in male and female outbred mice using traditional endpoints and hyperalgesia by Brewer, Abigail L., Lewis, Christina C., Eggerman, Liudmyla, Blokker, Alexis, Burkland, John A., Johnsen, Megan, Quock, Raymond M.

“…Opioid withdrawal significantly impacts drug dependence cycles as hyperalgesia associated with withdrawal is often a reason for continued drug use. Animal…”
Get full text

Effect of hyperbaric oxygen on chemotherapy-induced neuropathy in male and female rats by Brewer, Abigail L., Shirachi, Donald Y., Quock, Raymond M., Craft, Rebecca M.

“…Chemotherapeutic agents can cause peripheral neuropathy, a deleterious side effect of cancer treatment. Hyperbaric oxygen (HBO2) treatment has shown great…”
Get full text

Hyperbaric oxygen produces a nitric oxide synthase-regulated anti-allodynic effect in rats with paclitaxel-induced neuropathic pain by Zhang, Yangmiao, Brewer, Abigail L., Nelson, Jordan T., Smith, Paxton T., Shirachi, Donald Y., Quock, Raymond M.

“…•HBO2 produces an antiallodynic effect in paclitaxel-induced neuropathic pain.•HBO2 antiallodynia is antagonized by central infusion of nNOS-inhibitor.•HBO2…”
Get full text

Role of spinal GABA receptors in the acute antinociceptive response of mice to hyperbaric oxygen by Brewer, Abigail L., Liu, Shulin, Buhler, Amber V., Shirachi, Donald Y., Quock, Raymond M.

“…•HBO2-induced antinociception is mediated by spinal GABAA but not GABAB receptors.•Acetic acid reduced expression of nNOS and GABAA β3pSER 408/409.•HBO2…”
Get full text

Hyperbaric oxygen treatment suppresses withdrawal signs in morphine-dependent mice by Nicoara, Daniel, Zhang, Yangmiao, Nelson, Jordan T, Brewer, Abigail L, Maharaj, Prianka, DeWald, Shea N, Shirachi, Donald Y, Quock, Raymond M

“…Abstract Hyperbaric oxygen (HBO2 ) therapy reportedly reduces opiate withdrawal in human subjects. The purpose of this research was to determine whether HBO2…”
Get full text

Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA by Brewer, Abigail, Sathe, Gajanan, Pflug, Billie E., Clarke, Rosemary G., Macartney, Thomas J., Sapkota, Gopal P.

“…Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic…”
Get full text

Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling by Brewer, Abigail, Zhao, Jin-Feng, Fasimoye, Rotimi, Shpiro, Natalia, Macartney, Thomas J., Wood, Nicola T., Wightman, Melanie, Alessi, Dario R., Sapkota, Gopal P.

“…TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases,…”
Get full text

Targeted dephosphorylation of TFEB promotes its nuclear translocation by Zhao, Jin-Feng, Shpiro, Natalia, Sathe, Gajanan, Brewer, Abigail, Macartney, Thomas J., Wood, Nicola T., Negoita, Florentina, Sakamoto, Kei, Sapkota, Gopal P.

“…Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and…”
Get full text

Establishing a time course for spontaneous opioid withdrawal in male and female outbred mice using an abbreviated dependence paradigm by Quock, Raymond Mark, Brewer, Abigail Lucille

“…Opioid withdrawal is often a limiting factor in recovery from opioid dependence due to negative reinforcement caused by continued use of opioids in order to…”
Get full text

Target protein localization and its impact on PROTAC-mediated degradation by Simpson, Luke M, Glennie, Lorraine, Brewer, Abigail, Zhao, Jin-Feng, Crooks, Jennifer, Shpiro, Natalia, Sapkota, Gopal P

“…Proteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and…”
Get more information

Modeling spontaneous opioid withdrawal in male and female outbred mice using traditional endpoints and hyperalgesia by Brewer, Abigail L., Lewis, Christina C., Eggerman, Liudmyla, Blokker, Alexis, Burkland, John A., Johnsen, Megan, Quock, Raymond M.

Get full text

An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation by Simpson, Luke M, Fulcher, Luke J, Sathe, Gajanan, Brewer, Abigail, Zhao, Jin-Feng, Squair, Daniel R, Crooks, Jennifer, Wightman, Melanie, Wood, Nicola T, Gourlay, Robert, Varghese, Joby, Soares, Renata F, Sapkota, Gopal P

“…Reversible protein phosphorylation, catalyzed by protein kinases and phosphatases, is a fundamental process that controls protein function and intracellular…”
Get more information

Evaluation of hyperbaric oxygen (HBO2) as a treatment for hyperalgesia associated with naloxone‐precipitated withdrawal in morphine‐dependent mice by Brewer, Abigail Lucille, Shirachi, Donald Y., Quock, Raymond M.

“…Opioid dependence has become a major problem in the United States. Withdrawal from opioid drugs is associated with hyperalgesia (increased sensitivity to a…”
Get full text

Investigation of the Effects of Hyperbaric Oxygen (HBO2) on Opioid Withdrawal Using Both Behavioral and Molecular Techniques by Brewer, Abigail Lucille

“…Opioid dependence is likely impacted by repeated withdrawal cycles leading to the association of drug taking with relief of withdrawal symptoms which can…”
Get full text

Hyperbaric oxygen treatment suppresses withdrawal signs in opioid‐dependent mice (659.12) by Nicoara, Daniel, Zhang, Yangmiao, Nelson, Jordan, Brewer, Abigail, Shirachi, Donald, Quock, Raymond

“…HBO2 therapy has been approved by the Food and Drug Administration for limited clinical conditions (Gesell, The Hyperbaric Oxygen Therapy Committee Report:…”
Get full text

Brewing and "Fulachta Fiadh" by McClatchie, Meriel, Brewer, Abigail, Dillon, Mary, Johnston, Penny, Lyons, Susan, Monk, Mick, Stewart, Karen, Timpany, Scott

Get full text