Search Results - "Breusing, Nicolle"

Regulation of proteasome-mediated protein degradation during oxidative stress and aging by Breusing, Nicolle, Grune, Tilman

“…Protein degradation is a physiological process required to maintain cellular functions. There are distinct proteolytic systems for different physiological…”
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Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study by D’Aquila, Patrizia, Giacconi, Robertina, Malavolta, Marco, Piacenza, Francesco, Bürkle, Alexander, Villanueva, María Moreno, Dollé, Martijn E. T., Jansen, Eugène, Grune, Tilman, Gonos, Efstathios S., Franceschi, Claudio, Capri, Miriam, Grubeck-Loebenstein, Beatrix, Sikora, Ewa, Toussaint, Olivier, Debacq-Chainiaux, Florence, Hervonen, Antti, Hurme, Mikko, Slagboom, P. Eline, Schön, Christiane, Bernhardt, Jürgen, Breusing, Nicolle, Passarino, Giuseppe, Provinciali, Mauro, Bellizzi, Dina

“…The presence of circulating microbiome in blood has been reported in both physiological and pathological conditions, although its origins, identities and…”
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Relationship between Inflammation and Oxidative Stress and Cognitive Decline in the Institutionalized Elderly by Zibetti, Murilo, Medeiros Frescura Duarte, Marta Maria, Grune, Tilman, Breusing, Nicolle, Garcia, Solange C., Bordignon, Suelen, Durgante, Juliano, Gauer, Bruna, Freitas, Fernando, Brucker, Natália, Moro, Angela M., Nascimento, Sabrina N., Baierle, Marília, Trentini, Clarissa M.

“…Objective. Cognitive impairment reduces quality of life and is related to vascular and neurodegenerative disorders. However, there is also a close relationship…”
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Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study by Pinchuk, Ilya, Weber, Daniela, Kochlik, Bastian, Stuetz, Wolfgang, Toussaint, Olivier, Debacq-Chainiaux, Florence, Dollé, Martijn E T, Jansen, Eugène H J M, Gonos, Efstathios S, Sikora, Ewa, Breusing, Nicolle, Gradinaru, Daniela, Sindlinger, Thilo, Moreno-Villanueva, María, Bürkle, Alexander, Grune, Tilman, Lichtenberg, Dov

“…Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of…”
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Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries by Stuetz, Wolfgang, Weber, Daniela, Dollé, Martijn E T, Jansen, Eugène, Grubeck-Loebenstein, Beatrix, Fiegl, Simone, Toussaint, Olivier, Bernhardt, Juergen, Gonos, Efstathios S, Franceschi, Claudio, Sikora, Ewa, Moreno-Villanueva, María, Breusing, Nicolle, Grune, Tilman, Bürkle, Alexander

“…Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic…”
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The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1 by Grimm, Stefanie, Mvondo, Dagmar, Grune, Tilman, Breusing, Nicolle

“…Photodynamic therapy (PDT) is an important clinical approach for cancer treatment. It involves the administration of a photosensitizer, followed by its…”
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Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics by Kananen, Laura, Hurme, Mikko, Bürkle, Alexander, Moreno-Villanueva, Maria, Bernhardt, Jürgen, Debacq-Chainiaux, Florence, Grubeck-Loebenstein, Beatrix, Malavolta, Marco, Basso, Andrea, Piacenza, Francesco, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Jansen, Eugene H. J. M., Dollé, Martijn E. T., Salmon, Michel, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, Capri, Miriam, Franceschi, Claudio, Slagboom, Eline, Talbot, Duncan, Libert, Claude, Raitanen, Jani, Koskinen, Seppo, Härkänen, Tommi, Stenholm, Sari, Ala-Korpela, Mika, Lehtimäki, Terho, Raitakari, Olli T., Ukkola, Olavi, Kähönen, Mika, Jylhä, Marja, Jylhävä, Juulia

“…Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health…”
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Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project by Giacconi, Robertina, Costarelli, Laura, Piacenza, Francesco, Basso, Andrea, Bürkle, Alexander, Moreno-Villanueva, Maria, Grune, Tilman, Weber, Daniela, Stuetz, Wolfgang, Gonos, Efstathios S, Schön, Christiane, Grubeck-Loebenstein, Beatrix, Sikora, Ewa, Toussaint, Olivier, Debacq-Chainiaux, Florence, Franceschi, Claudio, Hervonen, Antti, Slagboom, Eline, Ciccarone, Fabio, Zampieri, Michele, Caiafa, Paola, Jansen, Eugène, Dollé, Martijn E T, Breusing, Nicolle, Mocchegiani, Eugenio, Malavolta, Marco

“…Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice…”
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Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study by Kochlik, Bastian, Herpich, Catrin, Moreno-Villanueva, María, Klaus, Susanne, Müller-Werdan, Ursula, Weinberger, Birgit, Fiegl, Simone, Toussaint, Olivier, Debacq-Chainiaux, Florence, Schön, Christiane, Bernhard, Jürgen, Breusing, Nicolle, Gonos, Efstathios S., Franceschi, Claudio, Capri, Miriam, Sikora, Ewa, Hervonen, Antti, Hurme, Mikko, Slagboom, P. Eline, Dollé, Martijn E. T., Jansen, Eugene, Grune, Tilman, Bürkle, Alexander, Norman, Kristina

“…Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional…”
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High-Resolution Quantitative Metabolome Analysis of Urine by Automated Flow Injection NMR by Da Silva, Laeticia, Godejohann, Markus, Martin, François-Pierre J, Collino, Sebastiano, Bürkle, Alexander, Moreno-Villanueva, María, Bernhardt, Jürgen, Toussaint, Olivier, Grubeck-Loebenstein, Beatrix, Gonos, Efstathios S, Sikora, Ewa, Grune, Tilman, Breusing, Nicolle, Franceschi, Claudio, Hervonen, Antti, Spraul, Manfred, Moco, Sofia

“…Metabolism is essential to understand human health. To characterize human metabolism, a high-resolution read-out of the metabolic status under various…”
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Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort by Schoissengeier, Vanessa, Maqboul, Lina, Weber, Daniela, Grune, Tilman, Bürkle, Alexander, Moreno-Villaneuva, Maria, Franceschi, Claudio, Capri, Miriam, Bernhard, Jürgen, Toussaint, Olivier, Debacq-Chainiaux, Florence, Weinberger, Birgit, Gonos, Efstathios S., Sikora, Ewa, Dollé, Martijn, Jansen, Eugène, Slagboom, P. Eline, Hervonnen, Antti, Hurme, Mikko, Breusing, Nicolle, Frank, Jan, Bulmer, Andrew C., Wagner, Karl-Heinz

“…Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of…”
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The Proteasome Is an Integral Part of Solar Ultraviolet A Radiation-induced Gene Expression by Catalgol, Betul, Ziaja, Isabella, Breusing, Nicolle, Jung, Tobias, Höhn, Annika, Alpertunga, Buket, Schroeder, Peter, Chondrogianni, Niki, Gonos, Efstathios S., Petropoulos, Isabelle, Friguet, Bertrand, Klotz, Lars-Oliver, Krutmann, Jean, Grune, Tilman

“…Solar ultraviolet (UV) A radiation is a well known trigger of signaling responses in human skin fibroblasts. One important consequence of this stress response…”
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Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study by Valentini, Elisabetta, Zampieri, Michele, Malavolta, Marco, Bacalini, Maria Giulia, Calabrese, Roberta, Guastafierro, Tiziana, Reale, Anna, Franceschi, Claudio, Hervonen, Antti, Koller, Bernhard, Bernhardt, Jürgen, Slagboom, P Eline, Toussaint, Olivier, Sikora, Ewa, Gonos, Efstathios S, Breusing, Nicolle, Grune, Tilman, Jansen, Eugène, Dollé, Martijn E T, Moreno-Villanueva, María, Sindlinger, Thilo, Bürkle, Alexander, Ciccarone, Fabio, Caiafa, Paola

“…Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC),…”
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Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly by Baierle, Marília, Vencato, Patrícia H, Oldenburg, Luiza, Bordignon, Suelen, Zibetti, Murilo, Trentini, Clarissa M, Duarte, Marta M M F, Veit, Juliana C, Somacal, Sabrina, Emanuelli, Tatiana, Grune, Tilman, Breusing, Nicolle, Garcia, Solange C

“…Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk…”
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Inverse correlation of protein oxidation and proteasome activity in liver and lung by Breusing, Nicolle, Arndt, Jana, Voss, Peter, Bresgen, Nicolaus, Wiswedel, Ingrid, Gardemann, Andreas, Siems, Werner, Grune, Tilman

“…Several studies have demonstrated that proteasome activity decreases whereas protein oxidation increases with aging in various tissues. However, no studies are…”
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An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples by Breusing, Nicolle, Grune, Tilman, Andrisic, Luka, Atalay, Mustafa, Bartosz, Grzegorz, Biasi, Fiorella, Borovic, Suzana, Bravo, Laura, Casals, Isidre, Casillas, Rosario, Dinischiotu, Anca, Drzewinska, Joanna, Faber, Heidemarie, Fauzi, Norsyahida Mohd, Gajewska, Agnieszka, Gambini, Juan, Gradinaru, Daniela, Kokkola, Tarja, Lojek, Antonin, Luczaj, Wojciech, Margina, Denisa, Mascia, Cinzia, Mateos, Raquel, Meinitzer, Andreas, Mitjavila, María Teresa, Mrakovcic, Lidija, Munteanu, Maria Cristina, Podborska, Martina, Poli, Giuseppe, Sicinska, Paulina, Skrzydlewska, Elzbieta, Vina, Jose, Wiswedel, Ingrid, Zarkovic, Neven, Zelzer, Sieglinde, Spickett, Corinne M

“…Lipid peroxidation products like malondialdehyde, 4-hydroxynonenal and F(2)-isoprostanes are widely used as markers of oxidative stress in vitro and in vivo…”
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Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study by Bacalini, Maria Giulia, Reale, Anna, Malavolta, Marco, Ciccarone, Fabio, Moreno-Villanueva, María, Dollé, Martijn E. T., Jansen, Eugène, Grune, Tilman, Gonos, Efstathios S., Schön, Christiane, Bernhardt, Jürgen, Grubeck-Loebenstein, Beatrix, Sikora, Ewa, Toussaint, Olivier, Debacq-Chainiaux, Florence, Capri, Miriam, Hervonen, Antti, Hurme, Mikko, Slagboom, P. Eline, Breusing, Nicolle, Aversano, Valentina, Tagliatesta, Stefano, Franceschi, Claudio, Blasco, Maria A., Bürkle, Alexander, Caiafa, Paola, Zampieri, Michele

“…Ageing leaves characteristic traces in the DNA methylation make-up of the genome. However, the importance of DNA methylation in ageing remains unclear. The…”
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Biomarkers of protein oxidation from a chemical, biological and medical point of view by Breusing, Nicolle, Grune, Tilman

“…In physiological conditions intracellular radical formation is mostly due to mitochondrial activity. This is in contrast to clinical and pathophysiological…”
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Relationship between actigraphy‐assessed sleep quality and fat mass in college students by Kahlhöfer, Julia, Karschin, Judith, Breusing, Nicolle, Bosy‐Westphal, Anja

“…Objective Only a few studies have used objective measurements to investigate the relationship between sleep quality and obesity. These studies showed…”
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Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome by Morsiani, Cristina, Bacalini, Maria Giulia, Collura, Salvatore, Moreno-Villanueva, María, Breusing, Nicolle, Bürkle, Alexander, Grune, Tilman, Franceschi, Claudio, De Eguileor, Magda, Capri, Miriam

“…Persons with Down syndrome (DS) undergo a premature ageing with early onset of age-related diseases. The main endpoint of this study was the identification of…”
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