Search Results - "Breum, Leif"

Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial by Astrup, Arne, Prof, Madsbad, Sten, Prof, Breum, Leif, MD, Jensen, Thomas J, MD, Kroustrup, Jens Peter, MD, Larsen, Thomas Meinert, PhD

“…Summary Background Weight-loss drugs produce an additional mean weight loss of only 3–5 kg above that of diet and placebo over 6 months, and more effective…”
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Effect of Metformin vs. Placebo in Combination with Insulin Analogues on Bone Markers P1NP and CTX in Patients with Type 2 Diabetes Mellitus by Nordklint, Azra Karahasanovic, Almdal, Thomas Peter, Vestergaard, Peter, Lundby-Christensen, Louise, Jørgensen, Niklas Rye, Boesgaard, Trine W., Breum, Leif, Gade-Rasmussen, Birthe, Sneppen, Simone B., Gluud, Christian, Hemmingsen, Bianca, Krarup, Thure, Madsbad, Sten, Mathiesen, Elisabeth R., Perrild, Hans, Tarnow, Lise, Thorsteinsson, Birger, Vestergaard, Henrik, Lund, Søren S., Eiken, Pia

“…Preclinical studies have shown a potential osteoanabolic effect of metformin but human studies of how metformin affects bone turnover are few. A post hoc…”
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Quality of life, patient satisfaction, and cardiovascular outcomes of the randomised 2 x 3 factorial Copenhagen insulin and Metformin therapy (CIMT) trial – A detailed statistical analysis plan by Olsen, Markus Harboe, Almdal, Thomas P., Madsbad, Sten, Ovesen, Christian, Gluud, Christian, Sneppen, Simone B., Breum, Leif, Hedetoft, Christoffer, Krarup, Thure, Lundby-Christensen, Louise, Mathiesen, Elisabeth R., Røder, Michael E., Vestergaard, Henrik, Wiinberg, Niels, Jakobsen, Janus C.

“…The evidence on the effects of metformin and insulin in type 2 diabetes patients on quality of life, patient satisfaction, and cardiovascular outcomes is…”
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Bilateral Primary Adrenal Lymphoma Presenting with Adrenal Insufficiency by Holm, Jakob, Breum, Leif, Stenfeldt, Katrine, Friberg Hitz, Mette

“…Lymphoma may occasionally involve the adrenal glands, but primary adrenal lymphoma (PAL) is very rare and only few cases have been reported. We present a case…”
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Exercise in newly diagnosed patients with multiple myeloma: A randomized controlled trial of effects on physical function, physical activity, lean body mass, bone mineral density, pain, and quality of life by Larsen, Rikke F., Jarden, Mary, Minet, Lisbeth R., Frølund, Ulf Christian, Hermann, Anne Pernille, Breum, Leif, Möller, Sören, Abildgaard, Niels

“…Reduced physical function caused by bone destruction, pain, anemia, infections, and weight loss is common in multiple myeloma (MM). Myeloma bone disease…”
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The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone by Rasmussen, M H, Frystyk, J, Andersen, T, Breum, L, Christiansen, J S, Hilsted, J

“…The aim of this study was to characterize the association between serum insulin-like growth factor-1 (IGF-1) and obesity, as well as fat distribution, before…”
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Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial by Larsen, Emil List, Kjær, Laura K., Lundby-Christensen, Louise, Boesgaard, Trine W., Breum, Leif, Gluud, Christian, Hedetoft, Christoffer, Krarup, Thure, Lund, Søren S., Mathiesen, Elisabeth R., Perrild, Hans, Sneppen, Simone B., Tarnow, Lise, Thorsteinsson, Birger, Vestergaard, Henrik, Poulsen, Henrik E., Madsbad, Sten, Almdal, Thomas P.

“…Formation of reactive oxygen species has been linked to the development of diabetes complications. Treatment with metformin has been associated with a lower…”
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Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes by Winckler, Karoline, Thorsteinsson, Birger, Wiinberg, Niels, Jensen, Andreas Kryger, Lundby-Christensen, Louise, Heitmann, Berit Lilienthal, Lund, Søren S., Krarup, Thure, Jensen, Tonny, Vestergaard, Henrik, Breum, Leif, Sneppen, Simone, Boesgaard, Trine, Madsbad, Sten, Gluud, Christian, Vaag, Allan, Almdal, Thomas P., Tarnow, Lise

“…To investigate measures of carotid intima-media thickness (IMT) and conventional cardiovascular (CV) risk factors as predictors of future carotid IMT, and the…”
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Under-reporting of adverse effects of tesofensine by Astrup, Arne, Madsbad, Sten, Breum, Leif, Jensen, Thomas J, Kroustrup, Jens P, Larsen, Thomas M

“…The Lancet Editors (April 6, p 1167)1 recently expressed concern regarding issues raised by the Danish Health and Medicines Authority (DHMA) audit2 of two of…”
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Metformin versus placebo in combination with insulin analogues in patients with type 2 diabetes mellitus—the randomised, blinded Copenhagen Insulin and Metformin Therapy (CIMT) trial by Lundby-Christensen, Louise, Tarnow, Lise, Boesgaard, Trine W, S Lund, Søren, Wiinberg, Niels, Perrild, Hans, Krarup, Thure, Snorgaard, Ole, Gade-Rasmussen, Birthe, Thorsteinsson, Birger, Røder, Michael, Mathiesen, Elisabeth R, Jensen, Tonny, Vestergaard, Henrik, Hedetoft, Christoffer, Breum, Leif, Duun, Elsebeth, Sneppen, Simone B, Pedersen, Oluf, Hemmingsen, Bianca, Carstensen, Bendix, Madsbad, Sten, Gluud, Christian, Wetterslev, Jørn, Vaag, Allan, Almdal, Thomas P

“…ObjectiveTo assess the effect of metformin versus placebo both in combination with insulin analogue treatment on changes in carotid intima-media thickness…”
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Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus: the randomised Copenhagen Insulin and Metformin Therapy (CIMT) trial by Lundby-Christensen, Louise, Vaag, Allan, Tarnow, Lise, Almdal, Thomas P, Lund, Søren S, Wetterslev, Jørn, Gluud, Christian, Boesgaard, Trine W, Wiinberg, Niels, Perrild, Hans, Krarup, Thure, Snorgaard, Ole, Gade-Rasmussen, Birthe, Thorsteinsson, Birger, Røder, Michael, Mathiesen, Elisabeth R, Jensen, Tonny, Vestergaard, Henrik, Hedetoft, Christoffer, Breum, Leif, Duun, Elsebeth, Sneppen, Simone B, Pedersen, Oluf, Hemmingsen, Bianca, Carstensen, Bendix, Madsbad, Sten

“…ObjectiveTo assess the effect of 3 insulin analogue regimens on change in carotid intima-media thickness (IMT) in patients with type 2 diabetes.Design and…”
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Prevalence of the metabolic syndrome in Danish psychiatric outpatients treated with antipsychotics by Krane-Gartiser, Karoline, Breum, Leif, Glümer, Charlotte, Linneberg, Allan, Madsen, Maiken, Køster, Anne, Jepsen, Peter W., Fink-Jensen, Anders

“…Background: The incidence of the metabolic syndrome, a major risk factor for diabetes and cardiovascular disease, is increasing worldwide and is suggested to…”
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Metabolic syndrome in a cohort of affectively ill patients, a naturalistic study by Vinberg, Maj, Madsen, Maiken, Breum, Leif, Kessing, Lars V., Fink-Jensen, Anders

“…Background: Patients with affective disorder have higher mortality not only because of their affective illness but also because of a higher risk of death from…”
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Prediction of excessive weight gain in insulin treated patients with type 2 diabetes by Cichosz, Simon Lebech, Lundby‐Christensen, Louise, Johansen, Mette D., Tarnow, Lise, Almdal, Thomas Peter, Hejlesen, Ole K., Group, The C.I.M.T. Trial

“…Background Weight gain is an ongoing challenge when initiating insulin therapy in patients with type 2 diabetes mellitus (T2DM). However, if prediction of…”
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Twenty-four–hour plasma tryptophan concentrations and ratios are below normal in obese subjects and are not normalized by substantial weight reduction by Breum, Leif, Rasmussen, Michael H, Hilsted, Jannik, Fernstrom, John D

“…Background: Plasma tryptophan concentrations and the ratio of tryptophan to other large neutral amino acids (plasma tryptophan ratio) are reportedly low in…”
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Reduced plasma noradrenaline concentrations in simple-obese and diabetic obese patients by Astrup, A V, Christensen, N J, Breum, L

“…1. Obesity may be associated with a decreased activity of the sympathetic nervous system and also with a deficiency of the response to stimuli activating the…”
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Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients : a randomised, double-blind, placebo-controlled trial. Commentary by BRAY, George A, ASTRUP, Arne, MADSBAD, Sten, BREUM, Leif, JENSEN, Thomas J, KROUSTRUP, Jens Peter, LARSEN, Thomas Meinert

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Abdominal obesity and associated comorbidities among primary care patients by Haugan, Ketil, Rost, Dan, Knudsen, Nils, Breum, Leif

“…Abdominal obesity is associated with type 2 diabetes, cardiovascular disease, dyslipidemia and hypertension. The prevalence of abdominal obesity and its…”
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Twenty-four–hour plasma tryptophan concentrations and ratios are below normal in obese subjects and are not normalized by substantial weight reduction12 by Breum, Leif, Rasmussen, Michael H, Hilsted, Jannik, Fernstrom, John D

“…Plasma tryptophan concentrations and the ratio of tryptophan to other large neutral amino acids (plasma tryptophan ratio) are reportedly low in obese subjects…”
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Twenty-four-house plasma tryptophan concentrations and ratios are below normal in obese subjects and are not normalized by substantial weight reduction by Breum, Leif, Rasmussen, Michael H, Hilsted, Jannik, Fernstrom, John D

“…Background: Plasma tryptophan concentrations and the ratio of tryptophan to other large neutral amino acids (plasma tryptophan ratio) are reportedly low in…”
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