Search Results - "Breuer, Raphael"

Forefront: MiR-34a-Knockout Mice with Wild Type Hematopoietic Cells, Retain Persistent Fibrosis Following Lung Injury by Bulvik, Raanan, Biton, Moshe, Berkman, Neville, Breuer, Raphael, Wallach-Dayan, Shulamit B

“…MicroRNAs (miRs) are known to limit gene expression at the post-transcriptional level and have important roles in the pathogenesis of various conditions,…”
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sFasL-The Key to a Riddle: Immune Responses in Aging Lung and Disease by Wallach-Dayan, Shulamit B, Petukhov, Dmytro, Ahdut-HaCohen, Ronit, Richter-Dayan, Mark, Breuer, Raphael

“…By dint of the aging population and further deepened with the Covid-19 pandemic, lung disease has turned out to be a major cause of worldwide morbidity and…”
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Osteopontin Induces Airway Remodeling and Lung Fibroblast Activation in a Murine Model of Asthma by Kohan, Martin, Breuer, Raphael, Berkman, Neville

“…Airway remodeling is a central feature of asthma; however, the mechanisms underlying its development have not been fully elucidated. We have demonstrated that…”
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A Profibrotic Phenotype in Naïve and in Fibrotic Lung Myofibroblasts Is Governed by Modulations in Thy-1 Expression and Activation by Cohen, Pazit Y., Wallach-Dayan, Shulamit B., Breuer, Raphael

“…Lung fibrosis is characterized by abnormal accumulation of Thy-deficient fibroblasts in the interstitium of the alveolar space. We have previously shown in…”
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SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis by Bulvik, Raanan, Breuer, Raphael, Dvir-Ginzberg, Mona, Reich, Eli, Berkman, Neville, Wallach-Dayan, Shulamit B

“…In contrast to normal regenerating tissue, resistance to Fas- and FasL-positive T cell-induced apoptosis were detected in myofibroblasts from fibrotic-lungs of…”
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CMH-Small Molecule Docks into SIRT1, Elicits Human IPF-Lung Fibroblast Cell Death, Inhibits Ku70-deacetylation, FLIP and Experimental Pulmonary Fibrosis by Konikov-Rozenman, Jenya, Breuer, Raphael, Kaminski, Naftali, Wallach-Dayan, Shulamit B

“…Regenerative capacity in vital organs is limited by fibrosis propensity. Idiopathic pulmonary fibrosis (IPF), a progressive lung disease linked with aging, is…”
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Evasion of myofibroblasts from immune surveillance: A mechanism for tissue fibrosis by Wallach-Dayan, Shulamit B, Golan-Gerstl, Regina, Breuer, Raphael

“…Tissue fibrosis evolving from impaired tissue remodeling after injury is characterized by myofibroblast accumulation. We propose that during the development of…”
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Matrix Metalloproteinases Retain Soluble FasL-mediated Resistance to Cell Death in Fibrotic-Lung Myofibroblasts by Nareznoi, David, Konikov-Rozenman, Jenya, Petukhov, Dmytro, Breuer, Raphael, Wallach-Dayan, Shulamit B

“…A prominent feature of obstructed tissue regeneration following injury in general, and fibrotic lung tissue in particular, is fibroblast proliferation and…”
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Overexpression of Telomerase Protects Human and Murine Lung Epithelial Cells from Fas- and Bleomycin-Induced Apoptosis via FLIP Upregulation by Arish, Nissim, Cohen, Pazit Y, Golan-Gerstl, Regina, Fridlender, Zvi, Dayan, Mark Richter, Zisman, Philip, Breuer, Raphael, Wallach-Dayan, Shulamit B

“…High doses of bleomycin administered to patients with lymphomas and other tumors lead to significant lung toxicity in general, and to apoptosis of epithelial…”
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Increased Regeneration Following Stress-Induced Lung Injury in Bleomycin-Treated Chimeric Mice with CD44 Knockout Mesenchymal Cells by Petukhov, Dmytro, Richter-Dayan, Mark, Fridlender, Zvi, Breuer, Raphael, Wallach-Dayan, Shulamit B

“…CD44, an adhesion-molecule promoting cell-migration, is shown here to increase in stress conditions following bleomycin-induced apoptosis in alveolar…”
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Epithelial Cell Apoptosis by Fas Ligand-Positive Myofibroblasts in Lung Fibrosis by Golan-Gerstl, Regina, Wallach-Dayan, Shulamit B, Amir, Gail, Breuer, Raphael

“…The Fas/Fas ligand (FasL) apoptotic pathway has been shown to be involved in bleomycin-induced lung fibrosis. We examined the hypothesis that myofibroblasts…”
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Bleomycin-Treated Chimeric Thy1-Deficient Mice with Thy1-Deficient Myofibroblasts and Thy-Positive Lymphocytes Resolve Inflammation without Affecting the Fibrotic Response by Cohen, Pazit Y., Breuer, Raphael, Zisman, Philip, Wallach-Dayan, Shulamit B.

“…Lung fibrosis is characterized by abnormal accumulation of fibroblasts in the interstitium of the alveolar space. Two populations of myofibroblasts,…”
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DNA vaccination with CD44 variant isoform reduces mammary tumor local growth and lung metastasis by Wallach-Dayan, Shulamit Batya, Rubinstein, Ariel M, Hand, Carla, Breuer, Raphael, Naor, David

“…We have shown recently that cDNA vaccination, using a virtual lymph node, ameliorates experimental allergic encephalomyelitis. Successful cure from mammary…”
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Positron emission tomography in interstitial lung disease by NUSAIR, Samir, RUBINSTEIN, Rina, FREEDMAN, Nanette M., AMIR, Gail, BOGOT, Naama R., IZHAR, Uzi, BREUER, Raphael

“…Background and objectives:  A high rate of glycolysis may reflect the inflammatory activity of interstitial lung disease (ILD). This prospective study…”
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Simultaneous donor marrow cell transplantation with reduced intensity conditioning prevents tracheal allograft obliteration in a bronchiolitis obliterans murine model by Nusair, Samir, Or, Reuven, Junadi, Samer, Amir, Gail, Breuer, Raphael

“…Prolonged survival of transplanted kidney or liver allografts has been associated with prolonged chimerism resulting from donor-origin leukocytes carried…”
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Short-term acupuncture therapy is of no benefit in patients with moderate persistent asthma by Shapira, Michael Y, Berkman, Neville, Ben-David, Gila, Avital, Avraham, Bardach, Elat, Breuer, Raphael

“…Acupuncture traditionally has been used to treat asthma. Nevertheless, only a few controlled studies have been performed to determine the efficacy of this…”
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The role of BAL in the diagnosis of pulmonary mucormycosis by Glazer, M, Nusair, S, Breuer, R, Lafair, J, Sherman, Y, Berkman, N

“…Five patients with pulmonary mucormycosis diagnosed during life are described. All had underlying predisposing conditions: either posttransplant or hematologic…”
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Effect of IL‐2‐Bax, a novel interleukin‐2‐receptor‐targeted chimeric protein, on bleomycin lung injury1 by Segel, Michael J., Aqeilan, Rami, Zilka, Keren, Lorberboum‐Galski, Haya, Wallach‐Dayan, Shulamit B., Conner, Michael W., Christensen, Thomas G., Breuer, Raphael

“…Summary The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro‐fibrotic effect for…”
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Differential diagnosis of pleural effusion by lactate dehydrogenase isoenzyme analysis by Lossos, I S, Breuer, R, Intrator, O, Sonenblick, M

“…To determine the diagnostic value of pleural fluid lactate dehydrogenase (LDH) isoenzyme analysis in the differential diagnosis of pleural fluid. Eighty-seven…”
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Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway by Wallach-Dayan, Shulamit B, Izbicki, Gabriel, Cohen, Pazit Y, Gerstl-Golan, Regina, Fine, Alan, Breuer, Raphael

“…Epithelial cells are considered to be a main target of bleomycin-induced lung injury, which leads to fibrosis in vivo. We studied the characteristics of in…”
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