Search Results - "Bretz, Niko"

Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling by Bretz, Niko P., Ridinger, Johannes, Rupp, Anne-Kathleen, Rimbach, Katharina, Keller, Sascha, Rupp, Christian, Marmé, Frederik, Umansky, Ludmila, Umansky, Viktor, Eigenbrod, Tatjana, Sammar, Marei, Altevogt, Peter

“…Tumor-derived exosomes have been shown to induce various immunomodulatory effects. However, the underlying signaling pathways are poorly understood. Here, we…”
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The CD24 surface antigen in neural development and disease by Gilliam, Daniel T, Menon, Vishal, Bretz, Niko P, Pruszak, Jan

“…Abstract A cell ' s surface molecular signature enables its reciprocal interactions with the associated microenvironments in development, tissue homeostasis…”
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Novel insights into exosome-induced, tumor-associated inflammation and immunomodulation by Altevogt, Peter, Bretz, Niko P, Ridinger, Johannes, Utikal, Jochen, Umansky, Viktor

“…Abstract The immune system of cancer patients is often suppressed. Accumulating evidence suggests that exosomes released from tumor cells may play an essential…”
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Contractile Forces Contribute to Increased Glycosylphosphatidylinositol-anchored Receptor CD24-facilitated Cancer Cell Invasion by Mierke, Claudia Tanja, Bretz, Niko, Altevogt, Peter

“…The malignancy of a tumor depends on the capability of cancer cells to metastasize. The process of metastasis involves cell invasion through connective tissue…”
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CD24 controls Src/STAT3 activity in human tumors by Bretz, Niko P., Salnikov, Alexei V., Perne, Claudia, Keller, Sascha, Wang, Xiaoli, Mierke, Claudia T., Fogel, Mina, Erbe-Hofmann, Natalie, Schlange, Thomas, Moldenhauer, Gerhard, Altevogt, Peter

“…CD24 is a glycosyl-phosphatidylinositol-anchored membrane protein that is frequently over-expressed in a variety of human carcinomas and is correlated with…”
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Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT by Doberstein, Kai, Harter, Patrick N., Haberkorn, Uwe, Bretz, Niko P., Arnold, Bernd, Carretero, Rafael, Moldenhauer, Gerhard, Mittelbronn, Michel, Altevogt, Peter

“…L1 cell adhesion molecule (L1CAM) is overexpressed in many human cancers, confers bad prognosis and augments cell motility, invasion and metastasis. Results…”
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miR-21-3p is a positive regulator of L1CAM in several human carcinomas by Doberstein, Kai, Bretz, Niko P, Schirmer, Uwe, Fiegl, Heidi, Blaheta, Roman, Breunig, Christian, Müller-Holzner, Elisabeth, Reimer, Dan, Zeimet, Alain G, Altevogt, Peter

“…Highlights • miR-21-3p is a positive regulator of L1CAM expression. • In patients we observed a strong positive correlation of L1CAM and miR-21-3p. • Although…”
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L1CAM is expressed in triple-negative breast cancers and is inversely correlated with androgen receptor by Doberstein, Kai, Milde-Langosch, Karin, Bretz, Niko P, Schirmer, Uwe, Harari, Ayelet, Witzel, Isabell, Ben-Arie, Alon, Hubalek, Michael, Müller-Holzner, Elisabeth, Reinold, Susanne, Zeimet, Alain G, Altevogt, Peter, Fogel, Mina

“…Breast cancer is a heterogeneous disease displaying distinct molecular features and clinical outcome. The molecular profile of triple-negative breast cancers…”
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Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma by Schirmer, Uwe, Doberstein, Kai, Rupp, Anne-Kathleen, Bretz, Niko P, Wuttig, Daniela, Kiefel, Helena, Breunig, Christian, Fiegl, Heidi, Müller-Holzner, Elisabeth, Zeillinger, Robert, Schuster, Eva, Zeimet, Alain G, Sültmann, Holger, Altevogt, Peter

“…L1CAM promotes cell motility, invasion and metastasis formation in various human cancers and can be considered as a driver of tumor progression. Knowledge…”
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Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons? by Krämer-Albers, Eva-Maria, Bretz, Niko, Tenzer, Stefan, Winterstein, Christine, Möbius, Wiebke, Berger, Hendrik, Nave, Klaus-Armin, Schild, Hansjörg, Trotter, Jacqueline

“…Oligodendrocytes synthesize the CNS myelin sheath by enwrapping axonal segments with elongations of their plasma membrane. Spatial and temporal control of…”
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Lack of CD24 expression in mice reduces the number of leukocytes in the colon by Bretz, Niko P, Salnikov, Alexei V, Doberstein, Kai, Garbi, Natalio, Kloess, Volker, Joumaa, Safwan, Naumov, Inna, Boon, Louis, Moldenhauer, Gerhard, Arber, Nadir, Altevogt, Peter

“…Highlights • We compared leukocytes in organs of CD24−/− vs. wildtype mice. • Highly decreased numbers of leukocytes in colons of CD24−/− mice were detected. •…”
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CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion by Bretz, Niko, Noske, Aurelia, Keller, Sascha, Erbe-Hofmann, Natalie, Schlange, Thomas, Salnikov, Alexei V., Moldenhauer, Gerd, Kristiansen, Glen, Altevogt, Peter

“…CD24 is a glycosyl-phosphatidylinositol-anchored protein with mucin-type structure that resides exclusively in membrane microdomains. CD24 is often highly…”
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Abstract B3: CD24 affects tumor cell properties and cytokine secretion in a STAT3-dependent fashion by Bretz, Niko P., Salnikov, Alexei V., Moldenhauer, Gerhard, Altevogt, Peter

“…Abstract CD24 is a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein frequently over-expressed in human carcinomas and associated with metastasis…”
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Molecular and clinical dissection of CD24 antibody specificity by a comprehensive comparative analysis by Kristiansen, Glen, Machado, Eda, Bretz, Niko, Rupp, Christian, Winzer, Klaus-Jürgen, König, Anne-Kathleen, Moldenhauer, Gerhard, Marmé, Frederik, Costa, Julia, Altevogt, Peter

“…CD24 is a small, highly glycosylated cell surface protein that is linked to the membrane through a glycosyl-phosphatidylinositol anchor. It is overexpressed in…”
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Abstract 3087: CD24 regulates tumor cell behaviour in a c-Src dependent fashion by Bretz, Niko P., Schlange, Thomas, Salnikov, Alexei V., Noske, Aurelia, Perne, Claudia, Moldenhauer, Gerhard, Kristiansen, Glen, Altevogt, Peter

“…Abstract CD24 is a glycosyl phosphatidylinositol (GPI)-anchored membrane protein that is frequently over-expressed in a variety of human carcinomas and is…”
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Abstract C59: Antibody targeting of CD24 efficiently retards growth of experimental carcinomas by Salnikov, Alexey V., Bretz, Niko, Perne, Claudia, Fogel, Mina, Keller, Sascha, Schlange, Thomas, Moldenhauer, Gerhard, Altevogt, Peter

“…Abstract It has been shown that CD24 drives lung metastasis formation of bladder cancer and might be a good candidate for mAb-dependent therapy. We tested…”
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CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer by Marmé, Frederik, Werft, Wiebke, Walter, Anne, Keller, Sascha, Wang, Xiaoli, Benner, Axel, Burwinkel, Barbara, Sinn, Peter, Hug, Sarah, Sohn, Christof, Bretz, Niko, Moldenhauer, Gerhard, Rupp, Christian, Rupp, Anne-Kathleen, Biakhov, Mikhail Y., Bottini, Alberto, Friedrichs, Kay, Khailenko, V. A., Manikhas, Georgiy M., Ruiz, Amparo, Sánchez-Rovira, Pedro, Santoro, Armando, Segui, Miguel A., Villena, Carlos, Lichter, Peter, Kristiansen, Glen, Altevogt, Peter, Schneeweiss, Andreas

“…Overexpression of CD24 is an independent prognostic factor for breast cancer. Recently, two polymorphisms in the CD24 gene were linked to disease risk and…”
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CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer by MARME, Frederik, WERFT, Wiebke, BRETZ, Niko, MOLDENHAUER, Gerhard, RUPP, Christian, RUPP, Anne-Kathleen, BIAKHOV, Mikhail Y, BOTTINI, Albert, FRIEDRICHS, Kay, KHAILENKO, V. A, MANIKHAS, Georgiy M, RUIZ, Amparo, WALTER, Anne, SANCHEZ-ROVIRA, Pedro, SANTORO, Armando, SEGUI, Miguel A, VILLENA, Carlos, LICHTER, Peter, KRISTIANSEN, Glen, ALTEVOGT, Peter, SCHNEEWEISS, Andreas, KELLER, Sascha, XIAOLI WANG, BENNER, Axel, BURWINKEL, Barbara, SINN, Peter, HUG, Sarah, SOHN, Christof

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