Search Results - "Brett M. Babin"

In situ visualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry by Hatzenpichler, Roland, Scheller, Silvan, Tavormina, Patricia L, Babin, Brett M, Tirrell, David A, Orphan, Victoria J

“…Here we describe the application of a new click chemistry method for fluorescent tracking of protein synthesis in individual microorganisms within…”
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SutA is a bacterial transcription factor expressed during slow growth in Pseudomonas aeruginosa by Babin, Brett M., Bergkessel, Megan, Sweredoski, Michael J., Moradian, Annie, Hess, Sonja, Newman, Dianne K., Tirrell, David A.

“…Microbial quiescence and slow growth are ubiquitous physiological states, but their study is complicated by low levels of metabolic activity. To address this…”
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Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis by Babin, Brett M, Fernandez-Cuervo, Gabriela, Sheng, Jessica, Green, Ori, Ordonez, Alvaro A, Turner, Mitchell L, Keller, Laura J, Jain, Sanjay K, Shabat, Doron, Bogyo, Matthew

“…Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point…”
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Activity-based protein profiling in bacteria: Applications for identification of therapeutic targets and characterization of microbial communities by Keller, Laura J., Babin, Brett M., Lakemeyer, Markus, Bogyo, Matthew

“…Activity-based protein profiling (ABPP) is a robust chemoproteomic technique that uses activity-based probes to globally measure endogenous enzymatic activity…”
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Covalent Library Screening by Targeted Mass Spectrometry for Rapid Binding Site Identification by Nonomiya, Jim, Li, Ke Sherry, Babin, Brett M., Mulvihill, Melinda M.

“…Interest in covalent drug discovery has surged in recent years, following the high-profile FDA approvals of covalent inhibitors that target BTK and KRAS G12C…”
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Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism by Babin, Brett M, Keller, Laura J, Pinto, Yishay, Li, Veronica L, Eneim, Andrew S, Vance, Summer E, Terrell, Stephanie M, Bhatt, Ami S, Long, Jonathan Z, Bogyo, Matthew

“…The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development of new…”
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Challenges for Targeting SARS-CoV‑2 Proteases as a Therapeutic Strategy for COVID-19 by Steuten, Kas, Kim, Heeyoung, Widen, John C, Babin, Brett M, Onguka, Ouma, Lovell, Scott, Bolgi, Oguz, Cerikan, Berati, Neufeldt, Christopher J, Cortese, Mirko, Muir, Ryan K, Bennett, John M, Geiss-Friedlander, Ruth, Peters, Christoph, Bartenschlager, Ralf, Bogyo, Matthew

“…Two proteases produced by the SARS-CoV-2 virus, the main protease and papain-like protease, are essential for viral replication and have become the focus of…”
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Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease by Babin, Brett M, Kasperkiewicz, Paulina, Janiszewski, Tomasz, Yoo, Euna, Dra̧g, Marcin, Bogyo, Matthew

“…Lon is a widely conserved housekeeping protease found in all domains of life. Bacterial Lon is involved in recovery from various types of stress, including…”
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Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in Pseudomonas aeruginosa Biofilms by Babin, Brett M, Atangcho, Lydia, van Eldijk, Mark B, Sweredoski, Michael J, Moradian, Annie, Hess, Sonja, Tolker-Nielsen, Tim, Newman, Dianne K, Tirrell, David A

“…Biofilm infections exhibit high tolerance against antibiotic treatment. The study of biofilms is complicated by phenotypic heterogeneity; biofilm…”
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Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host by Onguka, Ouma, Babin, Brett M, Lakemeyer, Markus, Foe, Ian T, Amara, Neri, Terrell, Stephanie M, Lum, Kenneth M, Cieplak, Piotr, Niphakis, Micah J, Long, Jonathan Z, Bogyo, Matthew

“…The intracellular protozoan parasite Toxoplasma gondii must scavenge cholesterol and other lipids from the host to facilitate intracellular growth and…”
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Covalent Modifiers of Botulinum Neurotoxin Counteract Toxin Persistence by Garland, Megan, Babin, Brett M, Miyashita, Shin-Ichiro, Loscher, Sebastian, Shen, Yi, Dong, Min, Bogyo, Matthew

“…Botulinum neurotoxins (BoNTs) are the most potent toxins known to man and a significant threat as weapons of bioterrorism. BoNTs contain a metalloprotease…”
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The dormancy‐specific regulator, SutA, is intrinsically disordered and modulates transcription initiation in Pseudomonas aeruginosa by Bergkessel, Megan, Babin, Brett M., VanderVelde, David, Sweredoski, Michael J., Moradian, Annie, Eggleston‐Rangel, Roxana, Hess, Sonja, Tirrell, David A., Artsimovitch, Irina, Newman, Dianne K.

“…Summary Though most bacteria in nature are nutritionally limited and grow slowly, our understanding of core processes like transcription comes largely from…”
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Noninvasive characterization of in situ forming implants using diagnostic ultrasound by Solorio, Luis, Babin, Brett M., Patel, Ravi B., Mach, Justyna, Azar, Nami, Exner, Agata A.

“…In situ forming drug delivery systems provide a means by which a controlled release depot can be physically inserted into a target site without the use of…”
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A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics by Walsh, Colin L, Babin, Brett M, Kasinskas, Rachel W, Foster, Jean A, McGarry, Marissa J, Forbes, Neil S

“…The heterogeneity of cellular microenvironments in tumors severely limits the efficacy of most cancer therapies. We have designed a microfluidic device that…”
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State-Selective Metabolic Labeling of Cellular Proteins by Ngo, John T, Babin, Brett M, Champion, Julie A, Schuman, Erin M, Tirrell, David A

“…Transcriptional activity from a specified promoter can provide a useful marker for the physiological state of a cell. Here we introduce a method for selective…”
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Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in italic toggle="yes">Pseudomonas aeruginosa /italic> Biofilms by Brett M. Babin, Lydia Atangcho, Mark B. van Eldijk, Michael J. Sweredoski, Annie Moradian, Sonja Hess, Tim Tolker-Nielsen, Dianne K. Newman, David A. Tirrell

“…ABSTRACT Biofilm infections exhibit high tolerance against antibiotic treatment. The study of biofilms is complicated by phenotypic heterogeneity; biofilm…”
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