Search Results - "Brett D. Keiper"

Cap-Independent mRNA Translation in Germ Cells by Keiper, Brett D

“…Cellular mRNAs in plants and animals have a 5'-cap structure that is accepted as the recognition point to initiate translation by ribosomes. Consequently, it…”
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Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse by Busada, Jonathan T., Chappell, Vesna A., Niedenberger, Bryan A., Kaye, Evelyn P., Keiper, Brett D., Hogarth, Cathryn A., Geyer, Christopher B.

“…In the testis, a subset of spermatogonia retains stem cell potential, while others differentiate to eventually become spermatozoa. This delicate balance must…”
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Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo by Busada, Jonathan T., Niedenberger, Bryan A., Velte, Ellen K., Keiper, Brett D., Geyer, Christopher B.

“…Spermatogonial stem cells (SSCs) must balance self-renewal with production of transit-amplifying progenitors that differentiate in response to retinoic acid…”
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Regulation of Germ Cell mRNPs by eIF4E:4EIP Complexes: Multiple Mechanisms, One Goal by Huggins, Hayden P., Keiper, Brett D.

“…Translational regulation of mRNAs is critically important for proper gene expression in germ cells, gametes, and embryos. The ability of the nucleus to control…”
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Spatial and temporal translational control of germ cell mRNAs mediated by the eIF4E isoform IFE-1 by Friday, Andrew J, Henderson, Melissa A, Morrison, J Kaitlin, Hoffman, Jenna L, Keiper, Brett D

“…Regulated mRNA translation is vital for germ cells to produce new proteins in the spatial and temporal patterns that drive gamete development. Translational…”
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A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification by Lee, Myon-Hee, Mamillapalli, Srivalli Swathi, Keiper, Brett D, Cha, Dong Seok

“…Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system…”
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Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism by Contreras, Vince, Friday, Andrew J, Morrison, J Kaitlin, Hao, Enhui, Keiper, Brett D

“…Apoptosis is a natural process during animal development for the programmed removal of superfluous cells. During apoptosis general protein synthesis is…”
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Translation of a Small Subset of Caenorhabditis elegans mRNAs Is Dependent on a Specific Eukaryotic Translation Initiation Factor 4E Isoform by Dinkova, Tzvetanka D., Keiper, Brett D., Korneeva, Nadejda L., Aamodt, Eric J., Rhoads, Robert E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reports : Contributed Mini Review ; A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification by Myon-hee Lee, Srivalli Swathi Mamillapalli, Brett D. Keiper, Dong Seok Cha

“…Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system…”
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GLH-1/Vasa represses neuropeptide expression and drives spermiogenesis in the C. elegans germline by Rochester, Jesse D., Min, Hyemin, Gajjar, Gita A., Sharp, Catherine S., Maki, Nathaniel J., Rollins, Jarod A., Keiper, Brett D., Graber, Joel H., Updike, Dustin L.

“…Germ granules harbor processes that maintain germline integrity and germline stem cell capacity. Depleting core germ granule components in C. elegans leads to…”
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Distinct roles of two eIF4E isoforms in the germline of Caenorhabditis elegans by Huggins, Hayden P, Subash, Jacob S, Stoffel, Hamilton, Henderson, Melissa A, Hoffman, Jenna L, Buckner, David S, Sengupta, Madhu S, Boag, Peter R, Lee, Myon-Hee, Keiper, Brett D

“…Germ cells use both positive and negative mRNA translational control to regulate gene expression that drives their differentiation into gametes. mRNA…”
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Subunits of the DNA polymerase alpha‐primase complex promote Notch‐mediated proliferation with discrete and shared functions in C. elegans germline by Yoon, Dong Suk, Cha, Dong Seok, Alfhili, Mohammad A., Keiper, Brett D., Lee, Myon‐Hee

“…Notch receptor signaling is a highly conserved cell communication system in most multicellular organisms and plays a critical role at several junctures in…”
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Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans by Flamand, Mathieu N, Wu, Edlyn, Vashisht, Ajay, Jannot, Guillaume, Keiper, Brett D, Simard, Martin J, Wohlschlegel, James, Duchaine, Thomas F

“…Cytoplasmic poly(A)-binding proteins (PABPs) link mRNA 3' termini to translation initiation factors, but they also play key roles in mRNA regulation and decay…”
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Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity by Friday, Andrew J., Keiper, Brett D.

“…Ultimately, the production of new proteins in undetermined cells pushes them to new fates. Other proteins hold a stem cell in a mode of self-renewal. In germ…”
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Translational Activation of Developmental Messenger RNAs During Neonatal Mouse Testis Development by CHAPPELL, Vesna A, BUSADA, Jonathan T, KEIPER, Brett D, GEYER, Christopher B

“…The basic tenets of germ cell development are conserved among metazoans. Following lineage commitment in the embryo, germ cells proliferate, transition into…”
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germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm by Henderson, Melissa A, Cronland, Elizabeth, Dunkelbarger, Steve, Contreras, Vince, Strome, Susan, Keiper, Brett D

“…Fertility and embryonic viability are measures of efficient germ cell growth and development. During oogenesis and spermatogenesis, new proteins are required…”
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C. elegans eIF4E-family member upregulates translation at elevated temperatures of mRNAs encoding MSH-5 and other meiotic crossover proteins by Song, Anren, Labella, Sara, Korneeva, Nadejda L, Keiper, Brett D, Aamodt, Eric J, Zetka, Monique, Rhoads, Robert E

“…Caenorhabditis elegans expresses five family members of the translation initiation factor eIF4E whose individual physiological roles are only partially…”
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Translational Activation of Developmental Messenger RNAs During Neonatal Mouse Testis Development1 by Chappell, Vesna A, Busada, Jonathan T, Keiper, Brett D, Geyer, Christopher B

“…The basic tenets of germ cell development are conserved among metazoans. Following lineage commitment in the embryo, germ cells proliferate, transition into…”
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An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans by Amiri, A, Keiper, B D, Kawasaki, I, Fan, Y, Kohara, Y, Rhoads, R E, Strome, S

“…Control of gene expression at the translational level is crucial for many developmental processes. The mRNA cap-binding protein, eIF4E, is a key player in…”
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Cleavage of Poly(A)-Binding Protein by Coxsackievirus 2A Protease In Vitro and In Vivo: Another Mechanism for Host Protein Synthesis Shutoff? by Kerekatte, V, Keiper, B D, Badorff, C, Cai, A, Knowlton, K U, Rhoads, R E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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