Search Results - "Brett, Sara J."

Impact of isotype on the mechanism of action of agonist anti-OX40 antibodies in cancer: implications for therapeutic combinations by Willoughby, Jane E, Dou, Lang, Bhattacharya, Sabyasachi, Jackson, Heather, Seestaller-Wehr, Laura, Kilian, David, Bover, Laura, Voo, Kui S, Cox, Kerry L, Murray, Tom, John, Mel, Shi, Hong, Bojczuk, Paul, Jing, Junping, Niederer, Heather, Shepherd, Andrew J, Hook, Laura, Hopley, Stephanie, Inzhelevskaya, Tatyana, Penfold, Chris A, Mockridge, C Ian, English, Vikki, Brett, Sara J, Srinivasan, Roopa, Hopson, Christopher, Smothers, James, Hoos, Axel, Paul, Elaine, Martin, Stephen L, Morley, Peter J, Yanamandra, Niranjan, Cragg, Mark S

“…BackgroundOX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet…”
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Depletion of LAG‐3+ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781 by Ellis, Joanne, J.B. Marks, Daniel, Srinivasan, Naren, Barrett, Christine, Hopkins, Thomas G., Richards, Anna, Fuhr, Rainard, Albayaty, Muna, Coenen, Martin, Liefaard, Lia, Leavens, Karen, Nevin, Katherine L., Tang, Shuo, Hughes, Stephen A., Fortunato, Léa, Edwards, Ken, Cui, Yi, Anselm, Rabia, Delves, Christopher J., Charles, Emilie, Feeney, Maria, Webb, Thomas M., Brett, Sara J., Schmidt, Tim S., Stone, John, Savage, Caroline O.S., Wisniacki, Nicolas, Tarzi, Ruth M.

“…Activated T cells drive a range of immune‐mediated inflammatory diseases. LAG‐3 is transiently expressed on recently activated CD4+ and CD8+ T cells. We…”
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Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes by Rowan, W C, Hale, G, Tite, J P, Brett, S J

“…The CAMPATH-1 (CD52) antigen is a 21-28 kDa glycopeptide which is highly expressed on lymphocytes and macrophages and is coupled to the membrane by a…”
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Emergence of CD52-, glycosylphosphatidylinositol-anchor-deficient lymphocytes in rheumatoid arthritis patients following Campath-1H treatment by Brett, S J, Baxter, G, Cooper, H, Rowan, W, Regan, T, Tite, J, Rapson, N

“…CD52 is a glycosylphosphatidyl-inositol (GPI)-linked glycoprotein expressed at high levels on normal T and B lymphocytes and at lower levels on monocytes,…”
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Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery by Thomsen, Lindy L., Topley, Peter, Daly, Maria G., Brett, Sara J., Tite, John P.

“…Imiquimod, an immune response modifier and inducer of cytokines in vitro and in vivo, has been shown to have potent antiviral and antitumour activity and to…”
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Development of an Escherichia coli Expressing Listeriolysin-O Vaccine Against Wilms Tumor Gene 1-expressing Tumors by DAI, Ming-Shen, NITCHEU-TEFIT, Josianne, ALCOCK, Sally, RAMIREZ-JIMENEZ, Francisco, CHAO, Tsu-Yi, BARIL, Patrick, ROCHA, Marian, BRETT, Sara J, STAUSS, Hans J, VASSAUX, Georges

“…Through their ability to induce cytotoxic T-lymphocytes and inhibit Foxp3 T-regulatory cells, Escherichia coli expressing listeriolysin-O (LLO) and a model…”
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Galactose Oxidation in the Design of Immunogenic Vaccines by Zheng, Biao, Brett, Sara J., Tite, John P., Lifely, M. Robert, Brodie, Thomas A., Rhodes, John

“…Potent immunological adjuvants are urgently required to complement recombinant and synthetic vaccines. However, it has not been possible to derive new…”
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Characterization of CC‐chemokine receptor 7 expression on murine T cells in lymphoid tissues by Bjorkdahl, Olle, Barber, Karen A., Brett, Sara J., Daly, Maria G., Plumpton, Christopher, Elshourbagy, Nabil A., Tite, John P., Thomsen, Lindy L.

“…Summary Expression of the lymph node homing and CC‐chemokine receptor 7 (CCR7), with L‐selectin (CD62L), has been shown to divide human memory T cells into two…”
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Expression of L-Selectin on Th1 Cells Is Regulated by IL-12 by Wely, Cathy A. van, Beverley, Peter C. L, Brett, Sara J, Britten, Christopher J, Tite, John P

“…L-selectin has become established as a key molecule in the recirculation of naïve T cells from the blood to peripheral lymph nodes, yet little is known about…”
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Emergence of CD52 −, glycosyiphosphatidylinositol-anchor deficient lymphocytes in rheumatoid arthritis patients following Campath-1H treatment by Brett, Sara J., Baxter, Gillian, Cooper, Helen, Rowan, Wendy, Regan, Tessa, Tite, John, Rapson, Nick

“…CD52 is a glycosylphosphatidyl-inositol (GPI)-llnked glycoprotein expressed at high levels on normal T and B lymphocytes and at lower levels on monocytes,…”
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Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery: DNA vaccines: research frontiers and clinical applications by THOMSEN, Lindy L, TOPLEY, Peter, DALY, Maria G, BRETT, Sara J, TITE, John P

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Influences of antigen processing on the expression of the T cell repertoire: evidence for MHC-specific hindering structures on the products of processing by BRETT, S. J, CEASE, K. B, BERZOFSKY, J. A

“…Two lines of evidence in the current study indicate that antigen processing is a major factor, in addition to MHC binding and T cell repertoire, that…”
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Antigen processing for presentation to T lymphocytes: function, mechanisms, and implications for the T-cell repertoire by Berzofsky, J A, Brett, S J, Streicher, H Z, Takahashi, H

“…Antigen processing encompasses the metabolic events that a protein antigen must undergo in or on the antigen-presenting cell before it can be recognized by the…”
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Pre-exposure of murine macrophages to lipopolysaccharide inhibits the induction of nitric oxide synthase and reduces leishmanicidal activity by Severn, A, Xu, D, Doyle, J, Leal, L M, O'Donnell, C A, Brett, S J, Moss, D W, Liew, F Y

“…Murine macrophages produce nitric oxide (NO) from L-arginine on stimulation with lipopolysaccharide (LPS), alone or with interferon-gamma (IFN-gamma). The…”
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Murine T cell-stimulatory peptides from the 19-kDa antigen of Mycobacterium tuberculosis. Epitope-restricted homology with the 28-kDa protein of Mycobacterium leprae by Harris, DP, Vordermeier, HM, Roman, E, Lathigra, R, Brett, SJ, Moreno, C, Ivanyi, J

“…Fifteen overlapping synthetic peptides, spanning the entire amino acid sequence of the Mycobacterium tuberculosis 19-kDa protein, were used to identify…”
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Human T cell recognition of influenza A nucleoprotein. Specificity and genetic restriction of immunodominant T helper cell epitopes by Brett, SJ, Blau, J, Hughes-Jenkins, CM, Rhodes, J, Liew, FY, Tite, JP

“…The characterization of human T cell antigenic sites on influenza A nucleoprotein (NP) is important for subunit vaccine development for either antibody…”
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Comparison of antigen presentation of influenza A nucleoprotein expressed in attenuated AroA- Salmonella typhimurium with that of live virus by Brett, SJ, Rhodes, J, Liew, FY, Tite, JP

“…Rationally attenuated strains of Salmonella expressing foreign proteins represent a potentially important vaccine delivery system. The characteristics of Ag…”
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Differential pattern of T cell recognition of the 65-kDa mycobacterial antigen following immunization with the whole protein or peptides by Brett, S J, Lamb, J R, Cox, J H, Rothbard, J B, Mehlert, A, Ivanyi, J

“…The 65-kDa stress protein from Mycobacterium bovis (Bacillus Calmette Guérin) elicited T cell proliferation and antibody responses in seven B10 congenic mouse…”
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Quantitative but Not Qualitative Variation in MHC Class II Alters CD4 Interaction and Influences T Cell Repertoire Formation by Fuller-Espie, Sheryl L., Murphy, Geraldine A., Brett, Sara J., Lechler, Robert I.

“…The influence of the interaction between CD4 and MHC class II molecules on selection of the T cell repertoire was studied in transgenic mice expressing human…”
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Immunodepression in Giardia muris and Spironucleus muris infections in mice by Brett, S J

“…Infections with the intestinal flagellates Giardia muris and Spironucleus muris are accompanied by a depression in the ability of mice to mount an immune…”
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