Search Results - "Brett, Ian C."

Tryptophan at the transmembrane–cytosolic junction modulates thrombopoietin receptor dimerization and activation by Defour, Jean-Philippe, Itaya, Miki, Gryshkova, Vitalina, Brett, Ian C., Pecquet, Christian, Sato, Takeshi, Smith, Steven O., Constantinescu, Stefan N.

“…Dimerization of single-pass membrane receptors is essential for activation. In the human thrombopoietin receptor (TpoR), a unique amphipathic RWQFP motif…”
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Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers by Defour, Jean-Philippe, Leroy, Emilie, Dass, Sharmila, Balligand, Thomas, Levy, Gabriel, Brett, Ian C, Papadopoulos, Nicolas, Mouton, Céline, Genet, Lidvine, Pecquet, Christian, Staerk, Judith, Smith, Steven O, Constantinescu, Stefan N

“…Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have…”
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Changing perspective on immunization against influenza by Johansson, Bert E, Brett, Ian C

“…Abstract Current vaccination strategies against influenza rely on decades old technology of strain selection and prolonged labor-intensive, embryonated…”
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Immunization against influenza A virus: Comparison of conventional inactivated, live-attenuated and recombinant baculovirus produced purified hemagglutinin and neuraminidase vaccines in a murine model system by Brett, Ian C., Johansson, Bert E.

“…To simulate the 2003–2004 influenza season and compare available vaccination methods, immunologically naive mice were immunized with: influenza A virus…”
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Synthesis, purification, and characterization of single helix membrane peptides and proteins for NMR spectroscopy by Itaya, Miki, Brett, Ian C, Smith, Steven O

“…Membrane proteins function as receptors, channels, transporters, and enzymes. These proteins are generally difficult to express and purify in a functional form…”
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Variation in the Divalent Cation Requirements of Influenza A Virus N1 Neuraminidases by Brett, Ian C, Johansson, Bert E

“…Enzymatic kinetic parameters of influenza A virus N1 neuraminidases (NA) chromatographically purified from several vaccine candidate strains were tested. With…”
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Recombinant Influenza B virus HA and NA antigens administered in equivalent amounts are immunogenically equivalent and induce equivalent homotypic and broader heterovariant protection in mice than conventional and live influenza vaccines by Johansson, Bert E., Brett, Ian C.

“…Influenza B virus is an important cause of acute upper respiratory disease in humans. Vaccination is the primary method of control of influenza related…”
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Variation in the Divalent Cation Requirements of Influenza A Virus N2 Neuraminidases by Johansson, Bert E., Brett, Ian C.

“…Influenza virus N2 neuraminidases were chromatographically purified from several vaccine candidate strains from 1957 to 1994. Enzymatic kinetic parameters and…”
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An Inactivated Subvirion Influenza A (H5N1) Vaccine by Johansson, Bert E, Brett, Ian C

“…To the Editor: Treanor et al. (March 30 issue) 1 conducted a well-designed study of a poor vaccine produced by methods that are used in the labor-intensive…”
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Structure of the Transmembrane Dimer of gp55-P of the Spleen Focus Forming Virus and its Interaction with the Erythropoietin Receptor by Itaya, Miki, Brett, Ian C., Liu, Wei, Constantinescu, Stefan N., Smith, Steven O.

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An Inactivated Subvirion Influenza A (H5N1) Vaccine/THE EDITORIALIST REPLIES by Johansson, Bert E, Brett, Ian C, Focosi, Daniele, Poland, Gregory A

“…TO THE EDITOR: [Treanor JJ] et al. (March 30 issue)1 conducted a well-designed study of a poor vaccine produced by methods that are used in the labor-intensive…”
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