Search Results - "Brett, Christopher L"

Evolutionary origins of eukaryotic sodium/proton exchangers by Brett, Christopher L, Donowitz, Mark, Rao, Rajini

“…More than 200 genes annotated as Na+/H+ hydrogen exchangers (NHEs) currently reside in bioinformation databases such as GenBank and Pfam. We performed detailed…”
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Immortal Time Bias in National Cancer Database Studies by Newman, Neil B., Brett, Christopher L., Kluwe, Christien A., Patel, Chirayu G., Attia, Albert, Osmundson, Evan C., Kachnic, Lisa A.

“…In studies evaluating the benefit of adjuvant therapies, immortal time bias (ITB) can affect the results by incorrectly reporting a survival advantage. It does…”
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Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae by Brett, Christopher L, Kallay, Laura, Hua, Zhaolin, Green, Richard, Chyou, Anthony, Zhang, Yongqiang, Graham, Todd R, Donowitz, Mark, Rao, Rajini

“…Protons, the smallest and most ubiquitous of ions, are central to physiological processes. Transmembrane proton gradients drive ATP synthesis, metabolite…”
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How and why intralumenal membrane fragments form during vacuolar lysosome fusion by Mattie, Sevan, McNally, Erin K, Karim, Mahmoud A, Vali, Hojatollah, Brett, Christopher L

“…Lysosomal membrane fusion mediates the last step of the autophagy and endocytosis pathways and supports organelle remodeling and biogenesis. Because fusogenic…”
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The Yeast Endosomal Na + (K + )/H + Exchanger Nhx1 Regulates Cellular pH to Control Vesicle Trafficking by Brett, Christopher L., Tukaye, Deepali N., Mukherjee, Sanchita, Rao, Rajini

“…The relationship between endosomal pH and function is well documented in viral entry, endosomal maturation, receptor recycling, and vesicle targeting within…”
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NHERF family and NHE3 regulation by Donowitz, Mark, Cha, Boyoung, Zachos, Nicholas C., Brett, Christopher L., Sharma, Annu, Tse, C. Ming, Li, Xuhang

“…The intestinal and renal proximal tubule brush border (BB) Na + –H + exchanger NHE3 binds to members of the NHERF (Na + –H + exchanger regulatory factor)…”
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Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase by Brett, Christopher L, Plemel, Rachael L, Lobinger, Braden T, Vignali, Marissa, Fields, Stanley, Merz, Alexey J

“…Rab guanosine triphosphatases (GTPases) are pivotal regulators of membrane identity and dynamics, but the in vivo pathways that control Rab signaling are…”
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Rho signaling participates in membrane fluidity homeostasis by Lockshon, Daniel, Olsen, Carissa Perez, Brett, Christopher L, Chertov, Andrei, Merz, Alexey J, Lorenz, Daniel A, Van Gilst, Marc R, Kennedy, Brian K

“…Preservation of both the integrity and fluidity of biological membranes is a critical cellular homeostatic function. Signaling pathways that govern lipid…”
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Intrinsic tethering activity of endosomal Rab proteins by Lo, Sheng-Ying, Brett, Christopher L, Plemel, Rachael L, Vignali, Marissa, Fields, Stanley, Gonen, Tamir, Merz, Alexey J

“…Rab small G proteins regulate membrane trafficking events by recruiting effectors that mediate vesicle tethering. In vitro studies now suggest that Vps21 and…”
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Osmotic Regulation of Rab-Mediated Organelle Docking by Brett, Christopher L., Merz, Alexey J.

“…Osmotic gradients across organelle and plasma membranes modulate the rates of membrane fission and fusion; sufficiently large gradients can cause membrane…”
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Inhibition of Sodium/Proton Exchange by a Rab-GTPase-activating Protein Regulates Endosomal Traffic in Yeast by Ali, Rashid, Brett, Christopher L., Mukherjee, Sanchita, Rao, Rajini

“…Endosomal Na+/H+ exchangers are important for salt and osmotolerance, vacuolar pH regulation, and endosomal trafficking. We show that the C terminus of yeast…”
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Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking by Mukherjee, Sanchita, Kallay, Laura, Brett, Christopher L, Rao, Rajini

“…Yeast Nhx1 [Na+(K+)/H+ exchanger 1] is an intracellular Na+(K+)/H+ exchanger, localizing to the late endosome where it is important for ion homoeostasis and…”
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Vps-C complexes: gatekeepers of endolysosomal traffic by Nickerson, Daniel P, Brett, Christopher L, Merz, Alexey J

“…Genetic studies in yeast, plants, insects, and mammals have identified four universally conserved proteins, together called Vps Class C, that are essential for…”
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Dedifferentiated Liposarcoma of the Esophagus: A Case Report and Selected Review of the Literature by Brett, Christopher L, Miller, Daniel H, Jiang, Liuyan, Wolfsen, Herbert C, Attia, Steven, Hintenlang, Lauren, Jagadesh, Niveditha, Miller, Robert C

“…Soft tissue sarcomas of the esophagus represent an extremely rare cause of esophageal masses, and an even smaller proportion of these tumors represent…”
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Sphingolipids containing very long-chain fatty acids regulate Ypt7 function during the tethering stage of vacuole fusion by Zhang, Chi, Calderin, Jorge D., Hurst, Logan R., Gokbayrak, Zeynep D., Hrabak, Michael R., Balutowski, Adam, Rivera-Kohr, David A., Kazmirchuk, Thomas D.D., Brett, Christopher L., Fratti, Rutilio A.

“…Sphingolipids are essential in membrane trafficking and cellular homeostasis. Here, we show that sphingolipids containing very long-chain fatty acids (VLCFAs)…”
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Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic by Plemel, Rachael L, Lobingier, Braden T, Brett, Christopher L, Angers, Cortney G, Nickerson, Daniel P, Paulsel, Andrew, Sprague, Debra, Merz, Alexey J

“…Traffic through late endolysosomal compartments is regulated by sequential signaling of small G proteins of the Rab5 and Rab7 families. The Saccharomyces…”
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Novel Workflow for Conversion of Catheter-Based Electroanatomic Mapping to DICOM Imaging for Noninvasive Radioablation of Ventricular Tachycardia by Brett, Christopher L., Cook, Jason A., Aboud, Asad A., Karim, Rashed, Shinohara, Eric T., Stevenson, William G.

“…A recent clinical trial has demonstrated that noninvasive radioablation (NIRA) has the potential to reduce recurrent ventricular tachycardia (VT) that is…”
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Recessive TRAPPC11 Mutations Cause a Disease Spectrum of Limb Girdle Muscular Dystrophy and Myopathy with Movement Disorder and Intellectual Disability by Bögershausen, Nina, Shahrzad, Nassim, Chong, Jessica X., von Kleist-Retzow, Jürgen-Christoph, Stanga, Daniela, Li, Yun, Bernier, Francois P., Loucks, Catrina M., Wirth, Radu, Puffenberger, Eric G., Hegele, Robert A., Schreml, Julia, Lapointe, Gabriel, Keupp, Katharina, Brett, Christopher L., Anderson, Rebecca, Hahn, Andreas, Innes, A. Micheil, Suchowersky, Oksana, Mets, Marilyn B., Nürnberg, Gudrun, McLeod, D. Ross, Thiele, Holger, Waggoner, Darrel, Altmüller, Janine, Boycott, Kym M., Schoser, Benedikt, Nürnberg, Peter, Ober, Carole, Heller, Raoul, Parboosingh, Jillian S., Wollnik, Bernd, Sacher, Michael, Lamont, Ryan E.

“…Myopathies are a clinically and etiologically heterogeneous group of disorders that can range from limb girdle muscular dystrophy (LGMD) to syndromic forms…”
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Effects of noradrenaline on intracellular pH in acutely dissociated adult rat hippocampal CA1 neurones by Smith, Garth A. M., Brett, Christopher L., Church, John

“…We examined the effects of noradrenaline on steady-state intracellular pH (pH i ) and the recovery of pH i from internal acid loads imposed by the NH 4 +…”
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Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria by Brett, Christopher L, Wei, Ying, Donowitz, Mark, Rao, Rajini

“…Since the discovery of the first intracellular Na(+)/H(+) exchanger in yeast, Nhx1, multiple homologs have been cloned and characterized in plants. Together,…”
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