Search Results - "Breton, John J"

Pharmacogenetic assessment of tafenoquine efficacy in patients with Plasmodium vivax malaria by St Jean, Pamela L., Koh, Gavin C.K.W., Breton, John J., Espino, Fe E.J., Hien, Tran T., Krudsood, Srivicha, Lacerda, Marcus V.G., Llanos-Cuentas, Alejandro, Lon, Chanthap, Mohammed, Rezika, Namaik-larp, Chayadol S., Pereira, Dhelio B., Saunders, David L., Velez, Ivan D., Yilma, Daniel, Villegas, Maria F., Duparc, Stephan, Green, Justin A.

“…Plasmodium vivax has the largest geographic range of human malaria species and is challenging to manage and eradicate due to its ability to establish a dormant…”
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Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria by Llanos-Cuentas, Alejandro, Lacerda, Marcus V.G., Hien, Tran T., Vélez, Iván D., Namaik-larp, Chayadol, Chu, Cindy S., Villegas, Maria F., Val, Fernando, Monteiro, Wuelton M., Brito, Marcelo A.M., Costa, Mônica R.F., Chuquiyauri, Raul, Casapía, Martín, Nguyen, Chau H., Aruachan, Sandra, Papwijitsil, Ratchadaporn, Nosten, François H., Bancone, Germana, Angus, Brian, Duparc, Stephan, Craig, Graham, Rousell, Victoria M., Jones, Siôn W., Hardaker, Elizabeth, Clover, Donna D., Kendall, Lindsay, Mohamed, Khadeeja, Koh, Gavin C.K.W., Wilches, Viviana M., Breton, John J., Green, Justin A.

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Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivax malaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase 2 trial by Vélez, Iván D, Hien, Tran T, Green, Justin A, Martin, Ana, Sharma, Hema, Rousell, Victoria M, Breton, John J, Ernest, Terry B, Rolfe, Katie, Taylor, Maxine, Mohamed, Khadeeja, Jones, Siôn W, Chau, Nguyen Hoang, Hoa, Nhu Thi, Duparc, Stephan, Tan, Lionel K, Goyal, Navin

“…Single-dose tafenoquine 300 mg is approved for Plasmodium vivax malaria relapse prevention in patients at least 16 years old. We aimed to determine appropriate…”
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A Randomized, Double-blind, Comparative Study to Assess the Safety and Efficacy of Topical Retapamulin Ointment 1% Versus Oral Linezolid in the Treatment of Secondarily Infected Traumatic Lesions and Impetigo Due to Methicillin-Resistant Staphylococcus aureus by Tanus, Tonny, Scangarella-Oman, Nicole E, Dalessandro, Marybeth, Li, Gang, Breton, John J, Tomayko, John F

“…OBJECTIVE:To evaluate the clinical and bacteriological efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of patients with…”
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The Safety and Efficacy of Topical Retapamulin Ointment Versus Placebo Ointment in the Treatment of Secondarily Infected Traumatic Lesions: A Randomized, Double-blind Superiority Study by TOMAYKO, John F, GANG LI, BRETON, John J, SCANGARELLA-OMAN, Nicole, DALESSANDRO, Marybeth, MARTIN, Michael

“…To evaluate whether retapamulin 1% is clinically superior to a placebo in the treatment of patients with secondarily infected traumatic lesions. The study was…”
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1-Substituted 4-Aryl-5-pyridinylimidazoles:  A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency by Boehm, Jeffrey C, Smietana, Juanita M, Sorenson, Margaret E, Garigipati, Ravi S, Gallagher, Timothy F, Sheldrake, Peter L, Bradbeer, Jeremy, Badger, Alison M, Laydon, Jeffrey T, Lee, John C, Hillegass, Leonard M, Griswold, Donald E, Breton, John J, Chabot-Fletcher, Marie C, Adams, Jerry L

“…A series of 1-alkyl- or -aryl-4-aryl-5-pyridinylimidazoles (A) were prepared and tested for their ability to bind to a recently discovered protein kinase…”
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Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria by Llanos-Cuentas, Alejandro, Lacerda, Marcus V.G, Hien, Tran T, Vélez, Iván D, Namaik-larp, Chayadol, Chu, Cindy S, Villegas, Maria F, Val, Fernando, Monteiro, Wuelton M, Brito, Marcelo A.M, Costa, Mônica R.F, Chuquiyauri, Raul, Casapía, Martín, Nguyen, Chau H, Aruachan, Sandra, Papwijitsil, Ratchadaporn, Nosten, François H, Bancone, Germana, Angus, Brian, Duparc, Stephan, Craig, Graham, Rousell, Victoria M, Jones, Siôn W, Hardaker, Elizabeth, Clover, Donna D, Kendall, Lindsay, Mohamed, Khadeeja, Koh, Gavin C.K.W, Wilches, Viviana M, Breton, John J, Green, Justin A

“…Malaria remains a global health burden. Elimination of the hypnozoite is required in patients infected with P. vivax to prevent relapse. In this report, the…”
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Effect of Staurosporine on Transcription Factor NF-κB in Human Keratinocytes by Chabot-Fletcher, Marie, Breton, John J

“…Activation of the transcription factor NF-κB is known to be important in the regulated expression of a large number of pro-inflammatory genes including…”
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A Randomized, Double-blind, Comparative Study to Assess the Safety and Efficacy of Topical Retapamulin Ointment 1% Venus Oral Linezolid in the Treatment of Secondarily Infected Traumatic Lesions and Impetigo Due to Methicillin-Resistant Staphylococcus aureus by Tanus, Tonny, Scangarella-Oman, Nicole E, Dalessandro, Marybeth, Li, Gang, Breton, John J, Tomayko, John F

“…Tanus et al evaluate the clinical and bacteriological efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of patients with…”
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Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells by Gardner, R C, Assinder, S J, Christie, G, Mason, G G, Markwell, R, Wadsworth, H, McLaughlin, M, King, R, Chabot-Fletcher, M C, Breton, J J, Allsop, D, Rivett, A J

“…Proteasomes are large multisubunit proteinases which have several distinct catalytic sites. In this study a series of di- and tri-peptidyl boronic acids have…”
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2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis by Gallagher, Timothy F., Fier-Thompson, Susan M., Garigipati, Ravi.S., Sorenson, Margaret E., Smietana, Juanita M., Lee, Dennis, Bender, Paul E., Lee, John C., Laydon, Jeffrey T., Griswold, Don E., Chabot-Fletcher, Marie C., Breton, John J., Adams, Jerry L.

“…As part of an effort to define the pharmacophore and discover the mechanism by which the antiinflammatory dual cyclooxygenase / 5-lipoxygenase inhibitors SK&F…”
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Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells by GARDNER, Robert C., ASSINDER, Stephen J., CHRISTIE, Gary, MASON, Grant G. F., MARKWELL, Roger, WADSWORTH, Harry, MCLAUGHLIN, Mark, KING, Ron, CHABOT-FLETCHER, Marie C., BRETON, John J., ALLSOP, David, RIVETT, A. Jennifer

“…Proteasomes are large multisubunit proteinases which have several distinct catalytic sites. In this study a series of di- and tri-peptidyl boronic acids have…”
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Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase:  Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea by Adams, Jerry L., Garigipati, Ravi S., Sorenson, Margaret, Schmidt, Stanley J., Brian, William R., Newton, John F., Tyrrell, Kathy A., Garver, Eric, Yodis, Lee A., Chabot-Fletcher, Marie, Tzimas, Maritsa, Webb, Edward F., Breton, John J., Griswold, Don E.

“…A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the…”
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Production of biologically active human RelA (p65) in baculovirus-infected insect cells by Chabot-Fletcher, M, Ho, M L, Breton, J J, Hanning, C R, Amegadzie, B Y

“…A recombinant baculovirus was constructed to express a cDNA encoding RelA (p65), a member of the NF-kappa B/Rel family of proteins. Infection of Spodoptera…”
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