Search Results - "Breteler, M.M.B"

Gait patterns in a community-dwelling population aged 50 years and older by Verlinden, V.J.A, van der Geest, J.N, Hoogendam, Y.Y, Hofman, A, Breteler, M.M.B, Ikram, M.A

“…Highlights ► We investigated the association of age with gait, focusing on normal walking, turning and tandem walking, in 1500 persons. ► Gait can be…”
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History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease by GEERLINGS, M. I, DEN HEIJER, T, KOUDSTAAL, P. J, HOFMAN, A, BRETELER, M. M. B

“…Depression may increase risk for Alzheimer disease (AD), but it is not clear whether this risk is mediated by structural brain changes. We determined whether…”
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White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging by Vernooij, M.W., de Groot, M., van der Lugt, A., Ikram, M.A., Krestin, G.P., Hofman, A., Niessen, W.J., Breteler, M.M.B.

“…The importance of macrostructural white matter changes, including white matter lesions and atrophy, in intact brain functioning is increasingly being…”
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Comparison between measures of atherosclerosis and risk of stroke: the Rotterdam Study by Hollander, M, Hak, A E, Koudstaal, P J, Bots, M L, Grobbee, D E, Hofman, A, Witteman, J C M, Breteler, M M B

“…Several measures of atherosclerosis predict the risk of stroke. However, a comparison between various measures of atherosclerosis is lacking, and limited…”
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Association between Early-Onset Parkinson's Disease and Mutations in the Parkin Gene by Lücking, Christoph B, Dürr, Alexandra, Bonifati, Vincenzo, Vaughan, Jenny, De Michele, Giuseppe, Gasser, Thomas, Harhangi, Biswadjiet S, Meco, Giuseppe, Denèfle, Patrice, Wood, Nicholas W, Agid, Yves, Nicholl, D, Breteler, M.M.B, Oostra, B.A, De Mari, M, Marconi, R, Filla, A, Bonnet, A.-M, Broussolle, E, Pollak, P, Rascol, O, Rosier, M, Arnould, Arnould, Brice, Alexis

“…Parkinson's disease is one of the most frequent neurodegenerative disorders, with a prevalence of 1 to 2 percent among persons older than 65 years of age. 1 It…”
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Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: The Rotterdam Study by HOLLANDER, M, BOTS, M. L, IGLESIAS DEL SOL, A, KOUDSTAAL, P. J, WITTEMAN, J. C. M, GROBBEE, D. E, HOFMAN, A, BRETELER, M. M. B

“…Few studies have quantified the relation between carotid plaques and stroke in asymptomatic patients, and limited data exist on the importance of location of…”
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Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis by Schuur, M, Ikram, M.A, van Swieten, J.C, Isaacs, A, Vergeer-Drop, J.M, Hofman, A, Oostra, B.A, Breteler, M.M.B, van Duijn, C.M

“…Abstract Cathepsin D ( CTSD ) is a gene involved in amyloid precursor protein processing and is considered a candidate for Alzheimer's disease (AD). The aim of…”
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Superficial siderosis in the general population by VERNOOIJ, M. W, IKRAM, M. A, HOFMAN, A, KRESTIN, G. P, BRETELER, M. M. B, VAN DER LUGT, A

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Prevalence of Parkinson's disease in the elderly: The Rotterdam Study by de Rijk, M.C, Breteler, M.M.B, Graveland, G.A, Ott, A, Grobbee, D.E, van der Meche, F.G.A, Hofman, A

“…We assessed the prevalence of Parkinson's disease (PD) in a general elderly population in the Netherlands.The study formed part of the Rotterdam Study, a…”
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Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries (CASCADE) by Launer, L J, Berger, K, Breteler, M M B, Dufouil, C, Fuhrer, R, Giampaoli, S, Nilsson, L-G, Pajak, A, de Ridder, M, van Dijk, E J, Sans, S, Schmidt, R, Hofman, A

“…White matter lesions (WML) on MRI of the brain are common in both demented and nondemented older persons. They may be due to ischemic events and are associated…”
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A population perspective on diagnostic criteria for Parkinson's disease by DE RIJK, M. C, ROCCA, W. A, ANDERSON, D. W, MELCON, M. O, BRETELER, M. M. B, MARAGANORE, D. M

“…For Parkinson's disease (PD), little is known about how the choice of diagnostic criteria affects research results. Using data on PD from three community…”
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Cerebral white matter lesions and atherosclerosis in the Rotterdam Study by Bots, M L, van Swieten, J C, Breteler, M M, de Jong, P T, van Gijn, J, Hofman, A, Grobbee, D E

“…Cerebral white matter lesions (WML) seen on magnetic resonance imaging scans are associated with cardiovascular disease and vascular risk factors. To assess…”
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P132 Fetal size and febrile seizures; the Generation R Study by Visser, A.M, Jaddoe, V.W.V, Hofman, A, Moll, H.A, Breteler, M.M.B, Arts, W.F.M

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Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study by Schrijvers, E M C, Verhaaren, B F J, Koudstaal, P J, Hofman, A, Ikram, M A, Breteler, M M B

“…To investigate whether dementia incidence has changed over the last 2 decades. We compared dementia incidence in 2 independent subcohorts of persons aged 60-90…”
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Cerebral microbleeds are associated with worse cognitive function: The Rotterdam Scan Study by POELS, M. M. F, IKRAM, M. A, VAN DER LUGT, A, HOFMAN, A, NIESSEN, W. J, KRESTIN, G. P, BRETELER, M. M. B, VERNOOIJ, M. W

“…Cerebral microbleeds are frequently found in the general elderly population and may reflect underlying vascular disease, but their role in cognitive function…”
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Prevalence and risk factors of cerebral microbleeds : The Rotterdam Scan Study by VERNOOIJ, M. W, VAN DER LUGT, A, IKRAM, M. A, WIELOPOLSKI, P. A, NIESSEN, W. J, HOFMAN, A, KRESTIN, G. P, BRETELER, M. M. B

“…Cerebral microbleeds are focal deposits of hemosiderin that can be visualized with MRI. Little is known on their prevalence in the general population and on…”
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Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study by SCHRIJVERS, E. M. C, WITTEMAN, J. C. M, SIJBRANDS, E. J. G, HOFMAN, A, KOUDSTAAL, P. J, BRETELER, M. M. B

“…Diabetes mellitus has been associated with an increased risk of Alzheimer disease (AD), but how it exerts its effect remains controversial. Possible…”
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PARK6 is a common cause of familial parkinsonism by Valente, E M, Brancati, F, Caputo, V, Graham, E A, Davis, M B, Ferraris, A, Breteler, M M B, Gasser, T, Bonifati, V, Bentivoglio, A R, De Michele, G, Dürr, A, Cortelli, P, Filla, A, Meco, G, Oostra, B A, Brice, A, Albanese, A, Dallapiccola, B, Wood, N W

“…The Parkin gene is responsible for about 50% of autosomal recessive juvenile parkinsonism (ARJP) and less than 20% of sporadic early onset cases. We recently…”
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Relation between smoking and risk of dementia and Alzheimer disease : The rotterdam study by REITZ, C, DEN HEIJER, T, VAN DUIJN, C, HOFMAN, A, BRETELER, M. M. B

“…Previous studies relating smoking with the risk of dementia have been inconsistent and limited in their validity by short follow-up times, large intervals…”
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Retinal vascular caliber and risk of dementia: The Rotterdam Study by DE JONG, F. J, SCHRIJVERS, E. M. C, IKRAM, M. K, KOUDSTAAL, P. J, DE JONG, P. T. V. M, HOFMAN, A, VINGERLING, J. R, BRETELER, M. M. B

“…Retinal vessels provide a unique opportunity to study both systemic and cerebrovascular disease. Smaller retinal arteriolar calibers are strongly related to…”
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