Electrochemical behavior of 5-type phosphodiesterase inhibitory drugs in solid state by voltammetry of immobilized microparticles

Electrochemical behavior of 5-type phosphodiesterase inhibitory drugs in solid state by voltammetry of immobilized microparticles

Evaluation of electrochemical behavior of 5-type phosphodiesterase inhibitory drugs is of major concern since they have been added illegally as adulterants in dietary supplements. Then, for the first time, the solid-sate electrochemistry of sildenafil and tadalafil is described using voltammetry of...

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Bibliographic Details
Published in:Journal of solid state electrochemistry Vol. 24; no. 8; pp. 1999 - 2010
Main Authors: da Silveira, Géssica Domingos, Bressan, Lucas Panes, Schmidt, Marcella Emilia Petra, Dal Molin, Thaís Ramos, Teixeira, Carlos Alberto, Poppi, Ronei Jesus, da Silva, José Alberto Fracassi
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2020
Springer Nature B.V
Subjects:
Adulterants
Analytical Chemistry
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Crystal structure
Dietary supplements
Drugs
Electrochemical analysis
Electrochemical cells
Electrochemical oxidation
Electrochemistry
Electrodes
Energy Storage
Fused deposition modeling
Microparticles
Original Paper
Oxidation
Paraffins
Physical Chemistry
Raman spectroscopy
Reduction
Sildenafil
Square waves
Sulfuric acid
Three dimensional models
Three dimensional printing
Voltammetry
Tadalafil
Solid state
Sildenafil
Adulterants
FDM-based 3D printer
Voltammetry of microparticles
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Summary:Evaluation of electrochemical behavior of 5-type phosphodiesterase inhibitory drugs is of major concern since they have been added illegally as adulterants in dietary supplements. Then, for the first time, the solid-sate electrochemistry of sildenafil and tadalafil is described using voltammetry of immobilized microparticles (VIMP). An electrochemical cell was designed and printed in a fused deposition modeling (FDM)-based 3D printer for VIMP measurements. The 3D-printed cell designed with a distance of 5 mm between the working and reference electrode presented better voltammetric response and decrease in the uncompensated resistance of the electrochemical system. Cyclic and square wave voltammograms of the individual compounds were recorded in a paraffin-impregnated graphite electrode in contact with 0.01 mol L −1 H 2 SO 4 . The electrochemical oxidation/reduction products were characterized by Raman spectroscopy and scanning electron microscopy (SEM). Different voltammetric responses were detected for the solid compounds depending on the solubility of the parent compound and their products of oxidation/reduction. Moreover, significant crystal re-structuring was also observed after voltammetric scan of the solid compounds. Under optimized conditions, sildenafil and tadalafil could be electrochemical identified and distinguished in dietary supplements.
ISSN:1432-8488
1433-0768
DOI:10.1007/s10008-020-04533-1