Anti-inflammatory and antioxidant properties of Alternanthera brasiliana improve cutaneous wound healing in rats

Alternanthera brasiliana (L.) Kuntze is recognized for its healing properties; however, its therapeutic effects remain unclear. Therefore, our study aimed to elucidate the wound healing activities of A. brasiliana using in vitro and in vivo assays. In vitro assays were used to evaluate the antibacte...

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Published in:	Inflammopharmacology Vol. 29; no. 5; pp. 1443 - 1458
Main Authors:	Marchete, Rogério, Oliveira, Sarah, Bagne, Leonardo, Silva, Jennyffer Ione de Souza, Valverde, Ana Paula, Aro, Andrea Aparecida de, Figueira, Mariana Moreira, Fronza, Marcio, Bressam, Thainá Mikaela, Goes, Vivian Fernandes Furletti de, Gaspari de Gaspi, Fernanda Oliveira de, dos Santos, Gláucia Maria Tech, Andrade, Thiago Antônio Moretti
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-10-2021
Subjects:	Allergology Amaranthaceae - chemistry Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antioxidants - isolation & purification Antioxidants - pharmacology Biomedical and Life Sciences Biomedicine Cell Line Dermatology Gastroenterology Immunology Inflammation - drug therapy Inflammation - pathology Male Mice Original Article Oxidative Stress - drug effects Pharmacology/Toxicology Plant Extracts - pharmacology Rats Rats, Wistar RAW 264.7 Cells Rheumatology Wound Healing - drug effects Angiogenesis Inflammation Wound healing Antioxidant Viability Collagen
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Summary:	Alternanthera brasiliana (L.) Kuntze is recognized for its healing properties; however, its therapeutic effects remain unclear. Therefore, our study aimed to elucidate the wound healing activities of A. brasiliana using in vitro and in vivo assays. In vitro assays were used to evaluate the antibacterial, anti-inflammatory, and antioxidant effects of A. brasiliana extract. For the in vivo study, two dorsal excisions were established in Wistar rats using a punch (1.5 cm in diameter), which were topically treated daily with 2% carbopol gel (Ctrl group) or 20% hydroalcoholic plant extract with 2% carbopol gel ( A. brasiliana –Ab group). After the 2nd, 7th, 14th, and 21st days, inflammation, oxidative damage, antioxidants, angiogenesis, tissue formation, and re-epithelialization were evaluated. In vitro, Ab reduced nitric oxide, anion superoxide, and pro-inflammatory cytokine production. In vivo, Ab presented lower levels of inflammatory infiltrate, although increased levels of IL-1β and TGF-β1 were observed. The plant extract controlled oxidative damage by antioxidants, which favored angiogenesis, collagenesis, and wound re-epithelialization. Thus, the topical application of the hydroalcoholic extract of 20% A. brasiliana was distinguished by its important anti-inflammatory and antioxidant activities both in vivo and in vitro. The plant extract also stimulated angiogenesis and tissue formation, accelerating total re-epithelization, which is promising for wound healing.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0925-4692 1568-5608
DOI:	10.1007/s10787-021-00862-3