Search Results - "Breslin, Paul A. S"

Activation and inhibition of the sweet taste receptor TAS1R2-TAS1R3 differentially affect glucose tolerance in humans by Kochem, Matthew C, Hanselman, Emily C, Breslin, Paul A S

“…The sweet taste receptor, TAS1R2-TAS1R3, is expressed in taste bud cells, where it conveys sweetness, and also in intestinal enteroendocrine cells, where it…”
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Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway by Breslin, Paul A S, Izumi, Akiko, Tharp, Anilet, Ohkuri, Tadahiro, Yokoo, Yoshiaki, Flammer, Linda J, Rawson, Nancy E, Margolskee, Robert F

“…The taste stimulus glucose comprises approximately half of the commercial sugar sweeteners used today, whether in the form of the di-saccharide sucrose…”
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Oral perceptions of fat and taste stimuli are modulated by affect and mood induction by Platte, Petra, Herbert, Cornelia, Pauli, Paul, Breslin, Paul A S

“…This study examined the impact of three clinical psychological variables (non-pathological levels of depression and anxiety, as well as experimentally…”
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Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin by Greene, Tiffani A, Alarcon, Suzanne, Thomas, Anu, Berdougo, Eli, Doranz, Benjamin J, Breslin, Paul A S, Rucker, Joseph B

“…Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs) expressed in gustatory cells. Each bitter taste receptor (TAS2R)…”
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Oral Cooling and Carbonation Increase the Perception of Drinking and Thirst Quenching in Thirsty Adults by Peyrot des Gachons, Catherine, Avrillier, Julie, Gleason, Michael, Algarra, Laure, Zhang, Siyu, Mura, Emi, Nagai, Hajime, Breslin, Paul A S

“…Fluid ingestion is necessary for life, and thirst sensations are a prime motivator to drink. There is evidence of the influence of oropharyngeal stimulation on…”
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Clofibrate inhibits the umami-savory taste of glutamate by Kochem, Matthew, Breslin, Paul A S

“…In humans, umami taste can increase the palatability of foods rich in the amino acids glutamate and aspartate and the 5'-ribonucleotides IMP and GMP. Umami…”
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Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste by Hwang, Liang-Dar, Gharahkhani, Puya, Breslin, Paul A S, Gordon, Scott D, Zhu, Gu, Martin, Nicholas G, Reed, Danielle R, Wright, Margaret J

“…Human perception of bitter substances is partially genetically determined. Previously we discovered a single nucleotide polymorphism (SNP) within the cluster…”
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The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12 by Reed, Danielle R., Zhu, Gu, Breslin, Paul A.S., Duke, Fujiko F., Henders, Anjali K., Campbell, Megan J., Montgomery, Grant W., Medland, Sarah E., Martin, Nicholas G., Wright, Margaret J.

“…The perceived taste intensities of quinine HCl, caffeine, sucrose octaacetate (SOA) and propylthiouracil (PROP) solutions were examined in 1457 twins and their…”
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Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal by Peyrot des Gachons, Catherine, Uchida, Kunitoshi, Bryant, Bruce, Shima, Asako, Sperry, Jeffrey B, Dankulich-Nagrudny, Luba, Tominaga, Makoto, Smith, 3rd, Amos B, Beauchamp, Gary K, Breslin, Paul A S

“…Oleocanthal, a major phenolic compound in extra-virgin olive oil with antiinflammatory properties, elicits an unusual oral pungency sensed almost exclusively…”
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A TAS1R receptor-based explanation of sweet ‘water-taste’ by Winnig, Marcel, Breslin, Paul A. S, Galindo-Cuspinera, Veronica, Meyerhof, Wolfgang, Bufe, Bernd

“…‘Water-tastes’ are gustatory after-impressions elicited by water following the removal of a chemical solution from the mouth, akin to colour after-images…”
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Salivary Amylase: Digestion and Metabolic Syndrome by Peyrot des Gachons, Catherine, Breslin, Paul A. S.

“…Salivary amylase is a glucose-polymer cleavage enzyme that is produced by the salivary glands. It comprises a small portion of the total amylase excreted,…”
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High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adults by Mandel, Abigail L, Breslin, Paul A S

“…In the current study, we determined whether increased digestion of starch by high salivary amylase concentrations predicted postprandial blood glucose…”
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Effect of Taste Sensation on Cough Reflex Sensitivity by Wise, Paul M., Breslin, Paul A. S., Dalton, Pamela

“…Cough is among the most common symptoms with which people present for medical attention, but evidence-based treatments remain limited. One issue compromising…”
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Individual Differences in Sour and Salt Sensitivity: Detection and Quality Recognition Thresholds for Citric Acid and Sodium Chloride by WISE, Paul M, BRESLIN, Paul A. S

“…Taste sensitivity is assessed with various techniques, including absolute detection and quality recognition. For any stimulus, one might expect individual…”
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Synthesis and Assignment of Absolute Configuration of (−)-Oleocanthal:  A Potent, Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived from Extra Virgin Olive Oils by Smith, Amos B, Han, Qiang, Breslin, Paul A. S, Beauchamp, Gary K

“…Effective total syntheses and the assignment of absolute configurations of both the (+)- and (−)-enantiomers of oleocanthal 1 (a.k.a. deacetoxy ligstroside…”
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New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances by Hwang, Liang-Dar, Lin, Cailu, Gharahkhani, Puya, Cuellar-Partida, Gabriel, Ong, Jue-Sheng, An, Jiyuan, Gordon, Scott D, Zhu, Gu, MacGregor, Stuart, Lawlor, Deborah A, Breslin, Paul A S, Wright, Margaret J, Martin, Nicholas G, Reed, Danielle R

“…Individual differences in human perception of sweetness are partly due to genetics; however, which genes are associated with the perception and the consumption…”
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Individual differences in AMY1 gene copy number, salivary α-amylase levels, and the perception of oral starch by Mandel, Abigail L, Peyrot des Gachons, Catherine, Plank, Kimberly L, Alarcon, Suzanne, Breslin, Paul A S

“…The digestion of dietary starch in humans is initiated by salivary α-amylase, an endo-enzyme that hydrolyzes starch into maltose, maltotriose and larger…”
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Twin Study of the Heritability of Recognition Thresholds for Sour and Salty Taste by Wise, Paul M., Hansen, Jonathan L., Reed, Danielle R., Breslin, Paul A.S.

“…Seventy-four pairs of monozygotic (identical) twins and 35 pairs of dizygotic (fraternal) twins provided recognition thresholds (modified Harris–Kalmus test)…”
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Sensory Characterization of the Irritant Properties of Oleocanthal, a Natural Anti-Inflammatory Agent in Extra Virgin Olive Oils by Cicerale, Sara, Breslin, Paul A.S., Beauchamp, Gary K., Keast, Russell S.J.

“…Oleocanthal is an olive oil phenolic possessing anti-inflammatory activity. Anecdotal evidence suggests that oleocanthal elicits a stinging sensation felt only…”
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(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells by Goren, Limor, Zhang, George, Kaushik, Susmita, Breslin, Paul A S, Du, Yi-Chieh Nancy, Foster, David A

“…(-)-Oleocanthal (oleocanthal) is a phenolic compound found in varying concentrations in extra virgin olive oil oleocanthal has been shown to be active…”
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