Search Results - "Breschi, M C"

Hydrogen sulphide: biopharmacological roles in the cardiovascular system and pharmaceutical perspectives by Martelli, A, Testai, L, Marino, A, Breschi, M C, Da Settimo, F, Calderone, V

“…Hydrogen sulphide (H(2)S) is now viewed as an important endogenous gasotransmitter, which exhibits many beneficial effects on the cardiovascular system. H(2)S…”
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Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs by Testai, L., Rapposelli, S., Martelli, A., Breschi, M.C., Calderone, V.

“…Brief periods of ischemia are known to confer to the myocardium an increased resistance to the injury due to a later and more prolonged ischemic episode. This…”
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Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines by Chicca, A., Adinolfi, B., Martinotti, E., Fogli, S., Breschi, M.C., Pellati, F., Benvenuti, S., Nieri, P.

“…Echinacea is one of the most widely used alternative medicine in the world. Intake of Echinacea preparations is common among patients with advanced…”
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Synergistic interaction between PPAR ligands and salbutamol on human bronchial smooth muscle cell proliferation by Fogli, S, Stefanelli, F, Picchianti, L, Del Re, M, Mey, V, Bardelli, C, Danesi, R, Breschi, MC

“…Background and Purpose An important objective in asthma therapy is to prevent the accelerated growth of airway smooth muscle cells which leads to hyperplasia…”
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Torsadogenic cardiotoxicity of antipsychotic drugs: a structural feature, potentially involved in the interaction with cardiac HERG potassium channels by Testai, L, Bianucci, A M, Massarelli, I, Breschi, M C, Martinotti, E, Calderone, V

“…Many non-cardiovascular drugs of common clinical use cause, as an unwanted accessory property, the prolongation of the cardiac repolarisation process, due to…”
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Does parity increase insulin resistance during pregnancy? by Seghieri, G., De Bellis, A., Anichini, R., Alviggi, L., Franconi, F., Breschi, M. C.

“…Aims  To study the effect of parity on impairment of insulin sensitivity during pregnancy and on the risk of gestational diabetes (GDM). Methods  We studied…”
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QT prolongation in guinea pigs for preliminary screening of torsadogenicity of drugs and drug-candidates. II by Testai, L., Breschi, M. C., Martinotti, E., Calderone, V.

“…Experimental approaches on anaesthetised guinea pigs have been shown recently to be satisfactorily predictive of the torsadogenic risk of drugs. This work…”
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Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels by Martelli, A., Testai, L., Breschi, M.C., Lawson, K., McKay, N.G., Miceli, F., Taglialatela, M., Calderone, V.

“…Hydrogen sulphide (H2S) has been recently hypothesized to be an endogenous adipocyte-derived relaxing factor, evoking vasorelaxation of conductance and…”
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QT prolongation in anaesthetized guinea-pigs: an experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates by Testai, L., Calderone, V., Salvadori, A., Breschi, M. C., Nieri, P., Martinotti, E.

“…Many non‐cardiovascular drugs can prolong the QT interval of the electrocardiogram (ECG); this is an accessory property not necessary for their pharmacological…”
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The activation of mitochondrial BK potassium channels contributes to the protective effects of naringenin against myocardial ischemia/reperfusion injury by Testai, L., Martelli, A., Marino, A., D’Antongiovanni, V., Ciregia, F., Giusti, L., Lucacchini, A., Chericoni, S., Breschi, M.C., Calderone, V.

“…Naringenin (NAR), flavonoid abundant in the genus Citrus, has been reported to interact with the large-conductance calcium-activated potassium channels (BK)…”
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Role of NF-κB and PPAR-γ in lung inflammation induced by monocyte-derived microparticles by Neri, T., Armani, C., Pegoli, A., Cordazzo, C., Carmazzi, Y., Brunelleschi, S., Bardelli, C., Breschi, M.C., Paggiaro, P., Celi, A.

“…Microparticles (MP) are phospholipid vesicles shed by cells upon activation or apoptosis. Monocyte-derived MP upregulate the synthesis of proinflammatory…”
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Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions by Testai, L., D'Antongiovanni, V., Piano, I., Martelli, A., Citi, V., Duranti, E., Virdis, A., Blandizzi, C., Gargini, C., Breschi, M.C., Calderone, V.

“…•Hypertensive coronary bed is hyporeactive to NO and H2S.•In normotension, H2S-induced coronary vasodilation obligatorily requires NO.•In normotension,…”
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Adenosine‐mediated hypotension in in vivo guinea‐pig: receptors involved and role of NO by Nieri, P, Martinotti, E, Calderone, V, Breschi, M C

“…Adenosine produced a biphasic lowering of the mean BP with a drastic bradycardic effect at the highest doses. The first phase hypotensive response was…”
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The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction by Martelli, A., Testai, L., Anzini, M., Cappelli, A., Di Capua, A., Biava, M., Poce, G., Consalvi, S., Giordani, A., Caselli, G., Rovati, L., Ghelardini, C., Patrignani, P., Sautebin, L., Breschi, M.C., Calderone, V.

“…Selective cyclooxygenase 2 (COX2) inhibitors (COXIBs) are effective anti-inflammatory and analgesic drugs with improved gastrointestinal (GI) safety compared…”
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Genetic characterization of the three medicinal Echinacea species using RAPD analysis by Nieri, P, Adinolfi, B, Morelli, I, Breschi, M C, Simoni, G, Martinotti, E

“…The three medicinal species of the Echinacea genus, E. angustifolia DC., E. pallida (Nutt.) Nutt. and E. purpurea (L.) Moench were distinguished using the RAPD…”
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Relation of birthweight to maternal plasma glucose and insulin concentrations during normal pregnancy by BRESCHI, M. C, SEGHIERI, G, BARTOLOMEI, G, GIRONI, A, BALDI, S, FERRANNINI, E

“…Maternal diabetes mellitus is complicated by fetal macrosomia and predisposes the offspring to diabetes, but recent evidence indicates that a low, not high,…”
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The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage by FOGLI, STEFANO, NIERI, PAOLA, CRISTINA BRESCHI, MARIA

“…Anthracycline antibiotics are potent antitumor agents whose activity is severely limited by a cumulative dose‐dependent chronic cardiotoxicity that results…”
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Vascular effects of aqueous crude extracts of Artemisia verlotorum Lamotte (Compositae): in vivo and in vitro pharmacological studies in rats by Calderone, V, Martinotti, E, Baragatti, B, Breschi, M.C, Morelli, I

“…Artemisia verlotorum Lamotte (Compositae), growing in almost all the northern hemisphere, is used in folk medicine of some countries of Tuscany, Italy, as a…”
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The [(Methyloxy)imino]methyl Moiety as a Bioisoster of Aryl. A Novel Class of Completely Aliphatic .beta.-Adrenergic Receptor Antagonists by Macchia, Bruno, Balsamo, Aldo, Breschi, M. C, Chiellini, Grazia, Macchia, Marco, Martinelli, Adriano, Martini, Claudia, Nardini, Claudia, Nencetti, Susanna

“…Previous studies in the field of beta-adrenergic drugs had supported the hypothesis of the existence of a bioisosterism between the [(methyleneamino)oxy]methyl…”
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Total plasma homocysteine correlates in women with gestational diabetes by Idzior-Waluś, B., Cyganek, K., Sztefko, K., Seghieri, G., Breschi, M. C., Waluś-Miarka, M., Kawalec, E., Seretny, M., Sieradzki, J.

“…Aim We aim to assess serum total homocysteine (tHcy) associations with metabolic syndrome components and B-vitamins in women with gestational diabetes mellitus…”
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