Search Results - "Brereton, Phillip S."

The First Agmatine/Cadaverine Aminopropyl Transferase: Biochemical and Structural Characterization of an Enzyme Involved in Polyamine Biosynthesis in the Hyperthermophilic Archaeon Pyrococcus furiosus by CACCIAPUOTI, Giovanna, PORCELLI, Marina, WANG, Bi-Cheng, BRERETON, Phillip S, JENNEY, Francis E, ADAMS, Michael W. W, MORETTI, Maria Angela, SORRENTINO, Francesca, CONCILIO, Luigi, ZAPPIA, Vincenzo, LIU, Zhi-Jie, TEMPEL, Wolfram, SCHUBOT, Florian, ROSE, John P

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Effect of Iron-Sulfur Cluster Environment in Modulating the Thermodynamic Properties and Biological Function of Ferredoxin from Pyrococcus furiosus by Brereton, Phillip S, Verhagen, Marc F. J. M, Zhou, Zhi H, Adams, Michael W. W

“…The ferredoxin (7.5 kDa) of the hyperthermophilic archaeon, Pyrococcus furiosus, contains a single [4Fe-4S]1+,2+ cluster that is coordinated by three Cys and…”
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GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant by Cole, Timothy J., Myles, Kathy, Purton, Jared F., Brereton, Phillip S., Solomon, Nicola M., Godfrey, Dale I., Funder, John W.

“…The introduction of a targeted insertion mutation into exon 2 of the gene coding for the glucocorticoid receptor (GR) enabled production of glucocorticoid…”
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Light and Electron Microscopy Localization of the 11β-Hydroxysteroid Dehydrogenase Type I Enzyme in the Rat by Brereton, Phillip S, van Driel, Rosemary R, Suhaimi, Farihah binti Haji, Koyama, Kaori, Dilley, Rod, Krozowski, Zygmunt

“…The 11β-hydroxysteroid dehydrogenase type I enzyme (11βHSD1) converts cortisone to cortisol in humans, and 11-dehydrocorticosterone to corticosterone in…”
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Probing the Stoichiometry and Oxidation States of Metal Centers in Iron−Sulfur Proteins Using Electrospray FTICR Mass Spectrometry by Johnson, Keith A, Verhagen, Marc F. J. M, Brereton, Phillip S, Adams, Michael W. W, Amster, I. Jonathan

“…Electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry is used to determine the stoichiometry and oxidation states of the…”
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Effect of Serinate Ligation at Each of the Iron Sites of the [Fe4S4] Cluster of Pyrococcus furiosus Ferredoxin on the Redox, Spectroscopic, and Biological Properties by Brereton, Phillip S, Duderstadt, Randall E, Staples, Christopher R, Johnson, Michael K, Adams, Michael W. W

“…Pyrococcus furiosus ferredoxin (Fd) contains a single [Fe4S4] cluster coordinated by three cysteine (at positions 11, 17, and 56) and one aspartate ligand (at…”
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Comparison of small- and large-scale expression of selected Pyrococcus furiosus genes as an aid to high-throughput protein production by Sugar, Frank J, Jenney, Jr, Francis E, Poole, 2nd, Farris L, Brereton, Phillip S, Izumi, Michi, Shah, Claudia, Adams, Michael W W

“…As the natural extension of the genomic sequencing projects, the goal of the various world-wide Structural Genomics projects is development of techniques for…”
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A pure S=3/2 [Fe 4S 4] + cluster in the A33Y variant of Pyrococcus furiosus ferredoxin by Duderstadt, Randall E, Brereton, Phillip S, Adams, Michael W.W, Johnson, Michael K

“…The properties of the [4Fe-4S] 2+/+ cluster in wild-type and the A33Y variant of Pyrococcus furiosus ferredoxin have been investigated by the combination of…”
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A Gallium-Substituted Cubane-Type Cluster in Pyrococcus f uriosus Ferredoxin by Johnson, Keith A, Brereton, Phillip S, Verhagen, Marc F. J. M, Calzolai, Luigi, La Mar, Gerd N, Adams, Michael W. W, Amster, I. Jonathan

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Spectroscopic Evidence for a New Type of [Fe3S4] Cluster in a Mutant Form of Pyrococcus furiosus Ferredoxin by Duderstadt, Randall E, Brereton, Phillip S, Adams, Michael W. W, Johnson, Michael K

“…In addition to the more established electron transfer and catalytic roles, there is increasing evidence that Fe-S clusters are intimately involved in…”
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Effects of Mutations in Aspartate 14 on the Spectroscopic Properties of the [Fe3S4]+,0 Clusters in Pyrococcus furiosus Ferredoxin by Duderstadt, Randall E, Staples, Christopher R, Brereton, Phillip S, Adams, Michael W. W, Johnson, Michael K

“…The properties of [Fe3S4]+,0 clusters in wild-type and mutant forms of Pf Fd with Asp, Ser, Cys, Val, His, Asn, and Tyr residues occupying position 14, i.e.,…”
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Comparison of Native and Mutant Proteins Provides a Sequence-Specific Assignment of the Cysteinyl Ligand Proton NMR Resonances in the 2[Fe4S4] Ferredoxin from Clostridium pasteurianum by Scrofani, Sergio D. B, Brereton, Phillip S, Hamer, Amanda M, Lavery, Megan J, McDowall, Sharon G, Vincent, Graham A, Brownlee, Robert T. C, Hoogenraad, Nicholas J, Sadek, Maruse, Wedd, Anthony G

“…A sequence-specific assignment is presented for the eight low-field paramagnetically shifted cysteinyl ligand proton NMR resonances in the 2[Fe4S4] ferredoxin…”
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A Gallium-Substituted Cubane-Type Cluster in Pyrococcus furiosus Ferredoxin by JOHNSON, Keith A., BRERETON, Phillip S., VERHAGEN, Marc F. J. M., CALZOLAI, Luigi, LA MAR, Gerd N., ADAMS, Michael W. W., AMSTER, I. Jonathan

“…Iron-sulfur (Fe-S) clusters are ubiquitous in nature and play a variety of roles including electron transfer and catalysis. One of the best studied is the…”
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Investigation of the role of surface residues in the ferredoxin from Clostridium pasteurianum by Brereton, PhillipS, Maher, MeganJ, Tregloan, PeterA, Wedd, AnthonyG

“…Eleven mutant forms of the ferredoxin from Clostridium pasteurianum ( CpFd; 2 Fe 4S 4; 6200 Da) have been isolated in which six surface carboxylates are…”
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