Search Results - "Brereton, Helen M."

Expression of an anti-CD4 single-chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats by Appleby, Sarah Louise, Jessup, Claire F, Mortimer, Lauren A, Kirk, Kirsty, Brereton, Helen M, Coster, Douglas John, Tan, Chuan K, Williams, Keryn A

“…To investigate whether expression of an anti-CD4 antibody fragment (scFv) by a lentivector-transduced donor cornea can prolong rat corneal allograft survival…”
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Kinetics of strain-dependent differential gene expression in oxygen-induced retinopathy in the rat by van Wijngaarden, Peter, Brereton, Helen M., Gibbins, Ian L., Coster, Douglas J., Williams, Keryn A.

“…Recent evidence suggests that retinopathy of prematurity, a potentially blinding condition of premature human neonates, has a genetically-determined component…”
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Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells by Brereton, Helen M, Chen, Jinglong, Rychkov, Grigori, Harland, M.Lyn, Barritt, Gregory J

“…The structures and mechanisms of activation of non-selective cation channels (NSCCs) are not well understood although NSCCs play important roles in the…”
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Local Gene Transfer to Modulate Rat Corneal Allograft Rejection by Jessup, Claire F, Brereton, Helen M, Sykes, Pamela J, Thiel, Michael A, Coster, Douglas J, Williams, Keryn A

“…Allograft rejection is the leading cause of corneal graft failure. CD4(+) T cells control the allograft response and represent targets for antirejection…”
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Interleukin-10 Gene Transfer in Rat Limbal Transplantation by Kaufmann, Claude, Mortimer, Lauren A, Brereton, Helen M, Irani, Yazad D, Parker, Douglas GA, Anson, Donald S, Bachmann, Lucas M, Williams, Keryn A

“…Purpose: To evaluate the gene transfer of the interleukin (IL)-10 cytokine as a treatment modality for prolonging limbal allograft survival in a rat model…”
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Co-expression of a scFv antibody fragment and a reporter protein using lentiviral shuttle plasmid containing a self-processing furin-2A sequence by Appleby, Sarah L., Irani, Yazad, Mortimer, Lauren A., Brereton, Helen M., Klebe, Sonja, Keane, Miriam C., Cowan, Peter J., Williams, Keryn A.

“…It is often desirable to co-express a reporter protein with a potential therapeutic protein, to verify correct targeting of an expression strategy. Vectors…”
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The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats by Brice, Sarah L, Kirk, Kirsty, Brereton, Helen M, Coster, Douglas J, Williams, Keryn A

“…To investigate the site of alloantigen presentation in the rat following orthotopic corneal transplantation. Adult inbred Fischer 344 rats received penetrating…”
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Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea by Parker, Douglas G, Coster, Douglas J, Brereton, Helen M, Hart, Prue H, Koldej, Rachel, Anson, Donald S, Williams, Keryn A

“…Background:  Gene transfer to a donor cornea ex vivo can modulate corneal graft failure in experimental animal models. We compared a lentiviral vector (LV)…”
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Genetic Influences on Susceptibility to Oxygen-Induced Retinopathy by van Wijngaarden, Peter, Brereton, Helen M, Coster, Douglas J, Williams, Keryn A

“…To investigate the inheritance of susceptibility to oxygen-induced retinopathy in the rat with the use of formal backcross analysis. Neonatal offspring of…”
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Strain-Dependent Differences in Oxygen-Induced Retinopathy in the Inbred Rat by van Wijngaarden, Peter, Coster, Douglas J, Brereton, Helen M, Gibbins, Ian L, Williams, Keryn A

“…To examine the susceptibilities of different rat strains to oxygen-induced retinopathy, a model of human retinopathy of prematurity. Litters of newborn rats of…”
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Single chain antibody fragments for ocular use produced at high levels in a commercial wheat variety by Brereton, Helen M., Chamberlain, Douglas, Yang, Rongchang, Tea, Melinda, McNeil, Scott, Coster, Douglas J., Williams, Keryn A.

“…We are investigating the use of single chain antibody fragments (scFv) in eye drops for diagnosis and treatment of eye diseases. For ocular use, recombinant…”
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PCR amplification of the functional immunoglobulin heavy chain variable gene from a hybridoma in the presence of two aberrant transcripts by Irani, Yazad, Tea, Melinda, Tilton, Ronald G., Coster, Douglas J., Williams, Keryn A., Brereton, Helen M.

“…Single chain antibody fragment genes are commonly created by splicing together the immunoglobulin light chain (VL) and heavy chain variable (VH) genes of a…”
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The potential of viral vector-mediated gene transfer to prolong corneal allograft survival by Parker, Douglas G A, Brereton, Helen M, Coster, Douglas J, Williams, Keryn A

“…The cornea is a particularly attractive target for gene therapy designed to improve the outcome of corneal transplantation. First, there is a clear and…”
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Hereditary influences in oxygen-induced retinopathy in the rat by van Wijngaarden, Peter, Brereton, Helen M., Coster, Douglas J., Williams, Keryn A.

“…Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an…”
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Plasma membrane Ca2+ release–Activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells by Rychkov, Grigori, Brereton, Helen M., Harland, M.Lyn, Barritt, Gregory J.

“…Repetitive waves of increased cytoplasmic Ca2+ concentration play a central role in the process by which hormones regulate liver function. Maintenance of these…”
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Antigens of selected Acanthamoeba species detected with monoclonal antibodies by Turner, Marian L., Cockerell, Emma J., Brereton, Helen M., Badenoch, Paul R., Tea, Melinda, Coster, Douglas J., Williams, Keryn A.

“…Acanthamoeba species are ubiquitous soil and freshwater protozoa that have been associated with infections of the human brain, skin, lungs and eyes. Our aim…”
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Evidence for the expression of transient receptor potential proteins in guinea pig airway smooth muscle cells by ONG, Hwei L., BRERETON, Helen M., HARLAND, M. Lyn, BARRITT, Greg J.

“…Objective:  The present study investigates the expression of transient receptor potential (TRPC) proteins in airway smooth muscle (ASM) cells in order to…”
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Gene expression microarray analysis of early oxygen-induced retinopathy in the rat by Tea, Melinda, Fogarty, Rhys, Brereton, Helen M., Michael, Michael Z., Van der Hoek, Mark B., Tsykin, Anna, Coster, Douglas J., Williams, Keryn A.

“…Different inbred strains of rat differ in their susceptibility to oxygen-induced retinopathy (OIR), an animal model of human retinopathy of prematurity. We…”
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Production of scFv antibody fragments from a hybridoma with functional activity against human vascular endothelial growth factor by Irani, Yazad, Brereton, Helen M, Tilton, Ronald G, Coster, Douglas J, Williams, Keryn A

“…Vascular endothelial growth factor (VEGF) plays a major role in the development of aberrant neovascularization in ocular diseases such as diabetic retinopathy…”
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A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein by Tesfai, Y, Brereton, H M, Barritt, G J

“…The structures, and mechanisms of activation, of plasma membrane intracellular-messenger-activated, non-selective cation channels in animal cells are not well…”
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