Search Results - "Brent, Thomas P."

Successful treatment of murine β-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells by Persons, Derek A., Allay, Esther R., Sawai, Nobukuni, Hargrove, Phillip W., Brent, Thomas P., Hanawa, Hideki, Nienhuis, Arthur W., Sorrentino, Brian P.

“…Successful gene therapy of β-thalassemia will require replacement of the abnormal erythroid compartment with erythropoiesis derived from genetically corrected,…”
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Biochemical Correlates of Temozolomide Sensitivity in Pediatric Solid Tumor Xenograft Models by Middlemas, D S, Stewart, C F, Kirstein, M N, Poquette, C, Friedman, H S, Houghton, P J, Brent, T P

“…The antitumor activity of the methylating agent temozolomide has been evaluated against a panel of 17 xenografts derived from pediatric solid tumors…”
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Cytoplasmic Sequestration of an O6-Methylguanine-DNA Methyltransferase Enhancer Binding Protein in DNA Repair-Deficient Human Cells by Chen, Frank Y., Harris, Linda C., Remack, Joanna S., Brent, Thomas P.

“…O6-Methylguanine-DNA methyltransferase (MGMT), an enzyme that repairs adducts at O6of guanine in DNA, is a major determinant of susceptibility to simple…”
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O6-Methylguanine-DNA Methyltransferase Gene: Epigenetic Silencing and Prognostic Value in Head and Neck Squamous Cell Carcinoma by Zuo, Chunlai, Ai, Lingbao, Ratliff, Pam, Suen, James Y, Hanna, Ehab, Brent, Thomas P, Fan, Chun-Yang

“…Background: Alkylating N -nitroso compounds can interact directly with DNA, forming O 6 -alkylguanine, a DNA adduct proved to be mutagenic and carcinogenic if…”
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Identification of the cross-link between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA by Gonzaga, P E, Potter, P M, Niu, T Q, Yu, D, Ludlum, D B, Rafferty, J A, Margison, G P, Brent, T P

“…Chloroethylnitrosoureas induce reactive O6-guanine adducts in DNA that can form either interstrand cross-links or a covalent complex with the DNA repair…”
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Extraneuronal Monoamine Transporter Expression and DNA Repair Vis-à-Vis 2-Chloroethyl-3-sarcosinamide-1-nitrosourea Cytotoxicity in Human Tumor Cell Lines by CHEN, Z.-P, REMACK, J, BRENT, T. P, MOHR, G, PANASCI, L. C

“…We previously found that 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), a new chloroethylnitrosourea analogue presently in phase I clinical trials, is a…”
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Protection and in Vivo Selection of Hematopoietic Stem Cells Using Temozolomide, O6-Benzylguanine, and an Alkyltransferase-Expressing Retroviral Vector by Sawai, Nobukuni, Zhou, Sheng, Vanin, Elio F., Houghton, Peter, Brent, Thomas P., Sorrentino, Brian P.

“…Transfer of drug resistance genes to hematopoietic stem cells offers the potential to protect cancer patients from drug-induced myelosuppression and to…”
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Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts by BRENT, T. P

“…Pulse treatment of DNA with any of several chloroethylnitrosoureas presently in clinical use leads to formation of monoadducts. Further incubation of these…”
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Antitumor Activity of Temozolomide Combined with Irinotecan Is Partly Independent of O6-Methylguanine-DNA Methyltransferase and Mismatch Repair Phenotypes in Xenograft Models by HOUGHTON, Peter J, STEWART, Clinton F, CHESHIRE, Pamela J, RICHMOND, Lois B, KIRSTEIN, Mark N, POQUETTE, Catherine A, MING TAN, FRIEDMAN, Henry S, BRENT, Thomas P

“…The activity of temozolomide combined with irinotecan (CPT-11) was evaluated against eight independent xenografts (four neuroblastomas, three…”
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Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in E. coli by Shiota, Susumu, Von Wronski, Mathew A, Tano, Keizo, Bigner, Darell D, Brent, Thomas P, Mitra, Sankar

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Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferease gene by Harris, Linda C., Remack, Joanna S., Brent, Thomas P.

“…The DNA repair enzyme, O6-methylguanine DNA methyltransferase (MGMT) is responsible for repair of damage induced by alkylating agents that produce adducts at…”
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Structure-activity relations of (2-chloroethyl)nitrosoureas. 2. Kinetic evidence of a novel mechanism for the cytotoxically important DNA cross-linking reactions of (2-chloroethyl)nitrosoureas by Buckley, Neil, Brent, Thomas P

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Properties of a human lymphoblast AP-endonuclease associated with activity for DNA damaged by ultraviolet light, .gamma.-rays, or osmium tetroxide by Brent, Thomas P

“…An endonuclease activity for UV-irradiated DNA, gamma-irradiated DNA, and OsO4-treated DNA that was partially purified from human lymphoblasts was found to…”
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Characterization of the promoter region of the human O 6 -methylguanine-DNA methyltransferase gene by Harris, Linda C., Potter, Philp M., Tano, Keizo, Shiota, Susumu, Mitra, Sankar, Brent, Thomas P.

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Epigenetic regulation of O 6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins by Danam, Rebecca P., Howell, Sherie R., Brent, Thomas P., Harris, Linda C.

“…Abstract Transcriptional silencing of the DNA repair gene, O6-methylguanine-DNA methyltransferase (MGMT) in a proportion of transformed cell lines is…”
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Response of cultured human cell lines from rhabdomyosarcoma xenografts to treatment with chloroethylnitrosoureas by SMITH, D. G, BRENT, T. P

“…DNA interstrand cross-links are thought to be the cytotoxic lesion resulting from treatment of cells with the chlorethylnitrosoureas (CENUs). We showed in an…”
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O 6 -Methylguanine-DNA Methyltransferase Gene: Epigenetic Silencing and Prognostic Value in Head and Neck Squamous Cell Carcinoma by Zuo, Chunlai, Ai, Lingbao, Ratliff, Pam, Suen, James Y., Hanna, Ehab, Brent, Thomas P., Fan, Chun-Yang

“…Abstract Background: Alkylating N-nitroso compounds can interact directly with DNA, forming O6-alkylguanine, a DNA adduct proved to be mutagenic and…”
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Partial purification and characterization of a human 3-methyladenine-DNA glycosylase by Brent, Thomas P

“…A DNA glycosylase was purified about 30-fold from cultured human lymphoblasts (CCRF-CEM line) and was found to cleave 3-methyladenine from DNA alkylated with…”
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Cytosine photoproduct-DNA glycosylase in Escherichia coli and cultured human cells by Weiss, Randi B, Gallagher, Patricia E, Brent, Thomas P, Duker, Nahum J

“…Ultraviolet irradiation of DNA produces a variety of pyrimidine base damages. The activities of Escherichia coli endonuclease III and a human lymphoblast…”
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Partial purification and characterization of 3-methyladenine-DNA glycosylase from human placenta by Gallagher, Patricia E, Brent, Thomas P

“…A DNA glycosylase was isolated and purified over 1000-fold from human placentas by means of diethylamino-ethylcellulose and double- and single-stranded…”
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