Search Results - "Brenner, K"

Immunotherapy against cancer-related viruses by Tashiro, Haruko, Brenner, Malcolm K

“…Approximately 12% of all cancers worldwide are associated with viral infections. To date, eight viruses have been shown to contribute to the development of…”
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S100 Proteins in Acute Myeloid Leukemia by Brenner, Annette K., Bruserud, Øystein

“…The S100 protein family contains 20 functionally expressed members, which are commonly dysregulated in cancer. Their wide range of functions includes cell…”
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Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent by Gomes-Silva, Diogo, Mukherjee, Malini, Srinivasan, Madhuwanti, Krenciute, Giedre, Dakhova, Olga, Zheng, Yueting, Cabral, Joaquim M.S., Rooney, Cliona M., Orange, Jordan S., Brenner, Malcolm K., Mamonkin, Maksim

“…Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency…”
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Mesenchymal Stem Cells Support Survival and Proliferation of Primary Human Acute Myeloid Leukemia Cells through Heterogeneous Molecular Mechanisms by Brenner, Annette K, Nepstad, Ina, Bruserud, Øystein

“…Acute myeloid leukemia (AML) is a bone marrow malignancy, and various bone marrow stromal cells seem to support leukemogenesis, including osteoblasts and…”
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Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma by Hegde, Meenakshi, Joseph, Sujith K., Pashankar, Farzana, DeRenzo, Christopher, Sanber, Khaled, Navai, Shoba, Byrd, Tiara T., Hicks, John, Xu, Mina L., Gerken, Claudia, Kalra, Mamta, Robertson, Catherine, Zhang, Huimin, Shree, Ankita, Mehta, Birju, Dakhova, Olga, Salsman, Vita S., Grilley, Bambi, Gee, Adrian, Dotti, Gianpietro, Heslop, Helen E., Brenner, Malcolm K., Wels, Winfried S., Gottschalk, Stephen, Ahmed, Nabil

“…Refractory metastatic rhabdomyosarcoma is largely incurable. Here we analyze the response of a child with refractory bone marrow metastatic rhabdomyosarcoma to…”
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Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy by Di Stasi, Antonio, Tey, Siok-Keen, Dotti, Gianpietro, Fujita, Yuriko, Kennedy-Nasser, Alana, Martinez, Caridad, Straathof, Karin, Liu, Enli, Liu, Hao, Durett, April G, Grilley, Bambi, Cruz, Conrad R, Savoldo, Barbara, Gee, Adrian P, Schindler, John, Krance, Robert A, Heslop, Helen E, Spencer, David M, Rooney, Cliona M, Brenner, Malcolm K

“…The introduction of a transgene into human donor T cells that can kill the cells when dimerization is induced by a pharmacologic agent has improved prospects…”
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Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma leukemia effects and safety by Hoyos, V, Savoldo, B, Quintarelli, C, Mahendravada, A, Zhang, M, Vera, J, Heslop, H E, Rooney, C M, Brenner, M K, Dotti, G

“…T lymphocytes expressing a chimeric antigen receptor (CAR) targeting the CD19 antigen (CAR.19) may be of value for the therapy of B-cell malignancies. Because…”
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Gradient discretization of a 3D-2D-1D mixed-dimensional diffusive model with resolved interface, application to the drying of a fractured porous medium by Brenner, K, Chave, Florent, Masson, R

“…Abstract We consider a 3D-2D-1D mixed-dimensional diffusive model in a fractured porous medium coupling the 1D model along the centerline skeleton of a tubular…”
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Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms by Brenner, Annette K, Reikvam, Håkon, Lavecchia, Antonio, Bruserud, Øystein

“…The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C. These three molecules are important regulators of several steps in the cell…”
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Vertex Approximate Gradient discretization preserving positivity for two-phase Darcy flows in heterogeneous porous media by Brenner, K., Masson, R., Quenjel, E.H.

“…•A new positive vertex approximation gradient scheme for heterogeneous porous media flows is proposed.•The scheme captures in an excellent way general…”
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Chimeric Antigen Receptors for T-Cell Malignancies by Scherer, Lauren D, Brenner, Malcolm K, Mamonkin, Maksim

“…Development of chimeric antigen receptor (CAR)-modified T cells for the treatment of T-lineage leukemia and lymphoma has encountered several unique challenges…”
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Targeting glycans for CAR therapy: The advent of sweet CARs by Raglow, Zoe, McKenna, Mary Kathryn, Bonifant, Challice L., Wang, Wenjing, Pasca di Magliano, Marina, Stadlmann, Johannes, Penninger, Josef M., Cummings, Richard D., Brenner, Malcolm K., Markovitz, David M.

“…Chimeric antigen receptor (CAR) T cell therapy has created a paradigm shift in the treatment of hematologic malignancies but has not been as effective toward…”
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Therapeutic Targeting of the Anaplastic Lymphoma Kinase (ALK) in Neuroblastoma—A Comprehensive Update by Brenner, Annette K., Gunnes, Maria W.

“…Neuroblastoma (NBL) is an embryonic malignancy of the sympathetic nervous system and mostly affects children under the age of five. NBL is highly heterogeneous…”
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Allogeneic, off-the-shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high-risk patients by Vasileiou, Spyridoula, Hill, LaQuisa, Kuvalekar, Manik, Workineh, Aster G, Watanabe, Ayumi, Velazquez, Yovana, Lulla, Suhasini, Mooney, Kimberly, Lapteva, Natalia, Grilley, Bambi J, Heslop, Helen E, Rooney, Cliona M, Brenner, Malcolm K, Eagar, Todd N, Carrum, George, Grimes, Kevin A, Leen, Ann M, Lulla, Premal

“…Defects in T-cell immunity to SARS-CoV-2 have been linked to an increased risk of severe COVID-19 (even after vaccination), persistent viral shedding and the…”
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Enhanced Tumor Trafficking of GD2 Chimeric Antigen Receptor T Cells by Expression of the Chemokine Receptor CCR2b by CRADDOCK, John A, AN LU, BEAR, Adham, PULE, Martin, BRENNER, Malcolm K, ROONEY, Cliona M, FOSTER, Aaron E

“…For adoptive T-cell therapy to be effective against solid tumors, tumor-specific T cells must be able to migrate to the tumor site. One requirement for…”
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Effect of Solvent Additive on Generation, Recombination, and Extraction in PTB7:PCBM Solar Cells: A Conclusive Experimental and Numerical Simulation Study by Kniepert, Juliane, Lange, Ilja, Heidbrink, Jan, Kurpiers, Jona, Brenner, Thomas J. K, Koster, L. Jan Anton, Neher, Dieter

“…Time-delayed collection field (TDCF), bias-assisted charge extraction (BACE), and space charge-limited current (SCLC) measurements are combined with complete…”
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A Distinct "Side Population" of Cells with High Drug Efflux Capacity in Human Tumor Cells by Hirschmann-Jax, C., Foster, A. E., Wulf, G. G., Nuchtern, J. G., Jax, T. W., Gobel, U., Goodell, M. A., Brenner, M. K., Prockop, Darwin J.

“…A subset of stem cells, termed the "side population" (SP), has been identified in several tissues in mammalian species. These cells maintain a high efflux…”
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The Complexity of Targeting PI3K-Akt-mTOR Signalling in Human Acute Myeloid Leukaemia: The Importance of Leukemic Cell Heterogeneity, Neighbouring Mesenchymal Stem Cells and Immunocompetent Cells by Brenner, Annette K, Andersson Tvedt, Tor Henrik, Bruserud, Øystein

“…Therapeutic targeting of PI3K-Akt-mTOR is considered a possible strategy in human acute myeloid leukaemia (AML); the most important rationale being the…”
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The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia by Johansen, Silje, Brenner, Annette K, Bartaula-Brevik, Sushma, Reikvam, Håkon, Bruserud, Øystein

“…Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive…”
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Highly Efficient Single-Layer Polymer Ambipolar Light-Emitting Field-Effect Transistors by Gwinner, Michael C., Kabra, Dinesh, Roberts, Matthew, Brenner, Thomas J. K., Wallikewitz, Bodo H., McNeill, Christopher R., Friend, Richard H., Sirringhaus, Henning

“…Single‐layer polymer light‐emitting field‐effect transistors (LEFETs) that yield EQEs of >8% and luminance efficiencies >28 cd A−1 are demonstrated. These…”
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