Search Results - "Brenner, J. Chad"

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1 , an unannotated lincRNA implicated in disease progression by Chinnaiyan, Arul M, Prensner, John R, Iyer, Matthew K, Balbin, O Alejandro, Dhanasekaran, Saravana M, Cao, Qi, Brenner, J Chad, Laxman, Bharathi, Asangani, Irfan A, Grasso, Catherine S, Kominsky, Hal D, Cao, Xuhong, Jing, Xiaojun, Wang, Xiaoju, Siddiqui, Javed, Wei, John T, Robinson, Daniel, Iyer, Hari K, Palanisamy, Nallasivam, Maher, Christopher A

“…New noncoding RNAs can be discovered by assembling transcripts from RNA-Seq data. Prensner et al . apply this approach across >100 prostate cancer samples to…”
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Prognosis to Radiation Unlocked: How Hypoxia Methylome May Hold the Key in HNSCC by Heft Neal, Molly E, Brenner, J Chad

“…Hypoxia in head and neck tumors has proven to be predictive of outcomes. Current hypoxia signatures have failed for patient treatment selection. In a recent…”
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Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer by Varambally, Sooryanarayana, Cao, Qi, Mani, Ram-Shankar, Shankar, Sunita, Wang, Xiaosong, Ateeq, Bushra, Laxman, Bharathi, Cao, Xuhong, Jing, Xiaojun, Ramnarayanan, Kalpana, Brenner, J. Chad, Yu, Jindan, Kim, Jung H, Han, Bo, Tan, Patrick, Kumar-Sinha, Chandan, Lonigro, Robert J, Palanisamy, Nallasivam, Maher, Christopher A, Chinnaiyan, Arul M

“…Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the…”
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PARP-1 Inhibition as a Targeted Strategy to Treat Ewing's Sarcoma by CHAD BRENNER, J, FENG, Felix Y, CHINNAIYAN, Arul M, HAN, Sumin, PATEL, Sonam, GOYAL, Siddharth V, BOU-MAROUN, Laura M, LIU, Meilan, LONIGRO, Robert, PRENSNER, John R, TOMLINS, Scott A

“…Ewing's sarcoma family of tumors (ESFT) refers to aggressive malignancies which frequently harbor characteristic EWS-FLI1 or EWS-ERG genomic fusions. Here, we…”
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Dual roles of PARP-1 promote cancer growth and progression by Schiewer, Matthew J, Goodwin, Jonathan F, Han, Sumin, Brenner, J Chad, Augello, Michael A, Dean, Jeffry L, Liu, Fengzhi, Planck, Jamie L, Ravindranathan, Preethi, Chinnaiyan, Arul M, McCue, Peter, Gomella, Leonard G, Raj, Ganesh V, Dicker, Adam P, Brody, Jonathan R, Pascal, John M, Centenera, Margaret M, Butler, Lisa M, Tilley, Wayne D, Feng, Felix Y, Knudsen, Karen E

“…PARP-1 is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation. PARP-1 has well-described functions in DNA damage repair and also…”
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Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma by Cao, Yue, Haring, Catherine T, Brummel, Collin, Bhambhani, Chandan, Aryal, Madhava, Lee, Choonik, Heft Neal, Molly, Bhangale, Apurva, Gu, Wenjin, Casper, Keith, Malloy, Kelly, Sun, Yilun, Shuman, Andrew, Prince, Mark E, Spector, Matthew E, Chinn, Steven, Shah, Jennifer, Schonewolf, Caitlin, McHugh, Jonathan B, Mills, Ryan E, Tewari, Muneesh, Worden, Francis P, Swiecicki, Paul L, Mierzwa, Michelle, Brenner, J Chad

“…In locally advanced p16+ oropharyngeal squamous cell carcinoma (OPSCC), (i) to investigate kinetics of human papillomavirus (HPV) circulating tumor DNA (ctDNA)…”
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The future of circulating tumor DNA as a biomarker in HPV related oropharyngeal squamous cell carcinoma by Haring, Catherine T., Dermody, Sarah M., Yalamanchi, Pratyusha, Kang, Stephen Y., Old, Matthew O., Chad Brenner, J., Spector, Matthew E., Rocco, James W.

“…•Human papillomavirus (HPV) circulating tumor (ct) DNA has emerged as a liquid biomarker in oropharyngeal cancer.•CtDNA levels correspond to disease burden and…”
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An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression by Yu, Jindan, Yu, Jianjun, Mani, Ram-Shankar, Cao, Qi, Brenner, Chad J., Cao, Xuhong, Wang, Xiaoju, Wu, Longtao, Li, James, Hu, Ming, Gong, Yusong, Cheng, Hong, Laxman, Bharathi, Vellaichamy, Adaikkalam, Shankar, Sunita, Li, Yong, Dhanasekaran, Saravana M., Morey, Roger, Barrette, Terrence, Lonigro, Robert J., Tomlins, Scott A., Varambally, Sooryanarayana, Qin, Zhaohui S., Chinnaiyan, Arul M.

“…Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG occur in approximately 50% of prostate…”
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Head and Neck Squamous Cell Carcinoma Detection and Surveillance: Advances of Liquid Biomarkers by Swiecicki, Paul L., Brennan, Julia R., Mierzwa, Michelle, Spector, Matthew E., Brenner, J. Chad

“…Head and neck squamous cell carcinomas are aggressive tumors that often present at advanced stage in difficult‐to‐biopsy regions of the head and neck. With the…”
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Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines by Brenner, J. Chad, Graham, Martin P., Kumar, Bhavna, Saunders, Lindsay M., Kupfer, Robbi, Lyons, Robert H., Bradford, Carol R., Carey, Thomas E.

“…Background. We established multiple University of Michigan Squamous Cell Carcinoma (UM‐SCC) cell lines. With time, these have been distributed to other labs…”
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A multi-center phase II trial evaluating the efficacy of palbociclib in combination with carboplatin for the treatment of unresectable recurrent or metastatic head and neck squamous cell carcinoma by Swiecicki, Paul L., Durm, Greg, Bellile, Emily, Bhangale, Apurva, Brenner, J. Chad, Worden, Francis P.

“…Summary Background Palbociclib is a selective inhibitor of CDK4/6 approved in metastatic breast cancer as well as evidence of activity in malignancies with…”
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Trans-Renal Cell-Free Tumor DNA for Urine-Based Liquid Biopsy of Cancer by Dermody, Sarah M, Bhambhani, Chandan, Swiecicki, Paul L, Brenner, J Chad, Tewari, Muneesh

“…Cancer biomarkers are a promising tool for cancer detection, personalization of therapy, and monitoring of treatment response or recurrence. "Liquid biopsy"…”
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From VA Larynx to the future of chemoselection: Defining the role of induction chemotherapy in larynx cancer by Spector, Matthew E., Rosko, Andrew J., Swiecicki, Paul L., Chad Brenner, J., Birkeland, Andrew C.

“…•Induction chemotherapy can select patients who will respond to organ preservation therapy.•The identification of biomarkers that can better predict response…”
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Association of human papillomavirus integration with better patient outcomes in oropharyngeal squamous cell carcinoma by Pinatti, Lisa M., Sinha, Hana N., Brummel, Collin V., Goudsmit, Christine M., Geddes, Timothy J., Wilson, George D., Akervall, Jan A., Brenner, Chad J., Walline, Heather M., Carey, Thomas E.

“…Background The molecular drivers of human papillomavirus‐related head and neck squamous cell carcinoma (HPV + HNSCC) are not entirely understood. This study…”
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Development of a high-performance multi-probe droplet digital PCR assay for high-sensitivity detection of human papillomavirus circulating tumor DNA from plasma by Bhambhani, Chandan, Sandford, Erin, Haring, Catherine T., Brummel, Collin, Tuck, Kirsten L., Olesnavich, Mary, Bhangale, Apurva D., Walline, Heather M., Dermody, Sarah M., Spector, Matthew E., Chinn, Steven B., Casper, Keith, Mierzwa, Michelle, Swiecicki, Paul L., Chad Brenner, J., Tewari, Muneesh

“…•Multi-probe ddPCR used to develop high-performance HPV16 ctDNA liquid biopsy assay.•9-fold higher analytical sensitivity than conventional single-probe ddPCR…”
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Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma by Birkeland, Andrew C, Foltin, Susan K, Michmerhuizen, Nicole L, Hoesli, Rebecca C, Rosko, Andrew J, Byrd, Serena, Yanik, Megan, Nor, Jacques E, Bradford, Carol R, Prince, Mark E, Carey, Thomas E, McHugh, Jonathan B, Spector, Matthew E, Brenner, J. Chad

“…Highlights • We calculated gene fusion rates in patients with mucoepidermoid carcinoma. • This is among the largest mucoepidermoid carcinoma cohorts to date. •…”
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Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma by Hoesli, Rebecca, Birkeland, Andrew C., Rosko, Andrew J., Issa, Mohamad, Chow, Kelsey L., Michmerhuizen, Nicole L., Mann, Jacqueline E., Chinn, Steven B., Shuman, Andrew G., Prince, Mark E., Wolf, Gregory T., Bradford, Carol R., McHugh, Jonathan B., Brenner, J. Chad, Spector, Matthew E.

“…•We explored the prognostic role of biomarkers in recurrent LSCC after RT/CRT.•Immunohistology included CD4, CD8, PDL-1, p16, CD31, Vimentin, EGFR, and…”
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Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer by Cao, Qi, Mani, Ram-Shankar, Ateeq, Bushra, Dhanasekaran, Saravana M., Asangani, Irfan A., Prensner, John R., Kim, Jung H., Brenner, J. Chad, Jing, Xiaojun, Cao, Xuhong, Wang, Rui, Li, Yong, Dahiya, Arun, Wang, Lei, Pandhi, Mithil, Lonigro, Robert J., Wu, Yi-Mi, Tomlins, Scott A., Palanisamy, Nallasivam, Qin, Zhaohui, Yu, Jindan, Maher, Christopher A., Varambally, Sooryanarayana, Chinnaiyan, Arul M.

“…Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG)…”
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HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING by Luo, Xiaobo, Donnelly, Christopher R., Gong, Wang, Heath, Blake R., Hao, Yuning, Donnelly, Lorenza A., Moghbeli, Toktam, Tan, Yee Sun, Lin, Xin, Bellile, Emily, Kansy, Benjamin A., Carey, Thomas E., Brenner, J. Chad, Cheng, Lei, Polverini, Peter J., Morgan, Meredith A., Wen, Haitao, Prince, Mark E., Ferris, Robert L., Xie, Yuying, Young, Simon, Wolf, Gregory T., Chen, Qianming, Lei, Yu L.

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Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma by Walline, Heather M, Komarck, Christine M, McHugh, Jonathan B, Bellile, Emily L, Brenner, J Chad, Prince, Mark E, McKean, Erin L, Chepeha, Douglas B, Wolf, Gregory T, Worden, Francis P, Bradford, Carol R, Carey, Thomas E

“…High-risk HPV (hrHPV) is the leading etiologic factor in oropharyngeal cancer. HPV-positive oropharyngeal tumors generally respond well to therapy, with…”
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