Search Results - "Brenner, Gary J."

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth by Mizrak, Arda, Bolukbasi, Mehmet Fatih, Ozdener, Gokhan Baris, Brenner, Gary J, Madlener, Sibylle, Erkan, Erdogan Pekcan, Ströbel, Thomas, Breakefield, Xandra O, Saydam, Okay

“…Microvesicles (MVs) play an important role in intercellular communication by carrying mRNAs, microRNAs (miRNAs), non-coding RNAs, proteins, and DNA from cell…”
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NLRP3 inflammasome activation in human vestibular schwannoma: Implications for tumor-induced hearing loss by Sagers, Jessica E., Sahin, Mehmet I., Moon, InSeok, Ahmed, Sherif G., Stemmer-Rachamimov, Anat, Brenner, Gary J., Stankovic, Konstantina M.

“…Vestibular schwannoma (VS) is the fourth most common intracranial tumor, arising from neoplastic Schwann cells of the vestibular nerve and often causing…”
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Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice by Ma, Chi Him Eddie, Omura, Takao, Cobos, Enrique J, Latrémolière, Alban, Ghasemlou, Nader, Brenner, Gary J, van Veen, Ed, Barrett, Lee, Sawada, Tomokazu, Gao, Fuying, Coppola, Giovanni, Gertler, Frank, Costigan, Michael, Geschwind, Dan, Woolf, Clifford J

“…Although peripheral nerves can regenerate after injury, proximal nerve injury in humans results in minimal restoration of motor function. One possible…”
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The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia by Taylor, Norman E., Long, Hu, Pei, JunZhu, Kukutla, Phanidhar, Phero, Anthony, Hadaegh, Farnaz, Abdelnabi, Ahmed, Solt, Ken, Brenner, Gary J.

“…A recently defined structure, the rostromedial tegmental nucleus (RMTg; aka tail of the ventral tegmental area [VTA]), has been proposed as an inhibitory…”
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TRPA1 contributes to cold hypersensitivity by del Camino, Donato, Murphy, Sarah, Heiry, Melissa, Barrett, Lee B, Earley, Taryn J, Cook, Colby A, Petrus, Matt J, Zhao, Michael, D'Amours, Marc, Deering, Nate, Brenner, Gary J, Costigan, Michael, Hayward, Neil J, Chong, Jayhong A, Fanger, Christopher M, Woolf, Clifford J, Patapoutian, Ardem, Moran, Magdalene M

“…TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety…”
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Schwannoma Gene Therapy via Adeno-Associated Viral Vector Delivery of Apoptosis-Associated Speck-like Protein Containing CARD (ASC): Preclinical Efficacy and Safety by Ahmed, Sherif G, Maguire, Casey A, Cao, Shiliang Alice, Brenner, Gary J

“…Schwannomas are tumors derived from Schwann-lineage cells, cells that protect and support myelinated nerves in the peripheral nervous system. They are…”
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miRNA-7 Attenuation in Schwannoma Tumors Stimulates Growth by Upregulating Three Oncogenic Signaling Pathways by SAYDAM, Okay, SENOL, Ozlem, BRENNER, Gary J, BREAKEFIELD, Xandra O, WÜRDINGER, Thomas, MIZRAK, Arda, BARIS OZDENER, Gokhan, STEMMER-RACHAMIMOV, Anat O, MING YI, STEPHENS, Robert M, KRICHEVSKY, Anna M, SAYDAM, Nurten

“…Micro RNAs (miRNA) negatively regulate protein-coding genes at the posttranscriptional level and are critical in tumorigenesis. Schwannomas develop from…”
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Culture of attenuated Salmonella Typhimurium VNP20009 in animal-product-free media does not alter schwannoma growth control by Ahmed, Sherif G., Oliva, Giulia, Shao, Manlin, Mekalanos, John J., Brenner, Gary J.

“…Schwannomas are slow-growing benign peripheral nerve sheath tumors derived from Schwann-lineage cells that develop in association with NF2-related…”
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Complement Induction in Spinal Cord Microglia Results in Anaphylatoxin C5a-Mediated Pain Hypersensitivity by Griffin, Robert S, Costigan, Michael, Brenner, Gary J, Him Eddie Ma, Chi, Scholz, Joachim, Moss, Andrew, Allchorne, Andrew J, Stahl, Gregory L, Woolf, Clifford J

“…Microarray expression profiles reveal substantial changes in gene expression in the ipsilateral dorsal horn of the spinal cord in response to three peripheral…”
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ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity by Ji, Ru-Rong, Befort, Katia, Brenner, Gary J, Woolf, Clifford J

“…Activation of ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein) kinase in dorsal horn neurons of the spinal cord by peripheral…”
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The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling by Ma, Chi H E, Brenner, Gary J, Omura, Takao, Samad, Omar A, Costigan, Michael, Inquimbert, Perrine, Niederkofler, Vera, Salie, Rishard, Sun, Chia Chi, Lin, Herbert Y, Arber, Silvia, Coppola, Giovanni, Woolf, Clifford J, Samad, Tarek A

“…Repulsive guidance molecule b (RGMb) is a bone morphogenetic protein (BMP) coreceptor and sensitizer of BMP signaling, highly expressed in adult dorsal root…”
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Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization by Kawasaki, Yasuhiko, Kohno, Tatsuro, Zhuang, Zhi-Ye, Brenner, Gary J, Wang, Haibin, Van Der Meer, Catrien, Befort, Katia, Woolf, Clifford J, Ji, Ru-Rong

“…Molecular mechanisms underlying C-fiber stimulation-induced ERK (extracellular signal-regulated kinase) activation in dorsal horn neurons and its contribution…”
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Bradykinin Enhances AMPA and NMDA Receptor Activity in Spinal Cord Dorsal Horn Neurons by Activating Multiple Kinases to Produce Pain Hypersensitivity by Kohno, Tatsuro, Wang, Haibin, Amaya, Fumimasa, Brenner, Gary J, Cheng, Jen-Kun, Ji, Ru-Rong, Woolf, Clifford J

“…Bradykinin potentiates synaptic glutamate release and action in the spinal cord via presynaptic and postsynaptic B(2) receptors, contributing thereby to…”
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Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice by Ezaka, Mariko, Marutani, Eizo, Miyazaki, Yusuke, Kanemaru, Eiki, Selig, Martin K., Boerboom, Sophie L., Ostrom, Katrina F., Stemmer-Rachamimov, Anat, Bloch, Donald B., Brenner, Gary J., Ohshima, Etsuo, Ichinose, Fumito

“…Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically…”
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Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity by Ji, Ru-Rong, Baba, Hiroshi, Brenner, Gary J, Woolf, Clifford J

“…We investigated the involvement of extracellular signal-regulated protein kinases (ERK) within spinal neurons in producing pain hypersensitivity. Within a…”
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Bradykinin Produces Pain Hypersensitivity by Potentiating Spinal Cord Glutamatergic Synaptic Transmission by Wang, Haibin, Kohno, Tatsuro, Amaya, Fumimasa, Brenner, Gary J, Ito, Nobuko, Allchorne, Andrew, Ji, Ru-Rong, Woolf, Clifford J

“…Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold. We now show that the B2 kinin receptor is expressed…”
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Transcriptomic signature of painful human neurofibromatosis type 2 schwannomas by Kukutla, Phanidhar, Ahmed, Sherif G., DuBreuil, Daniel M., Abdelnabi, Ahmed, Cetinbas, Murat, Fulci, Giulia, Aldikacti, Berent, Stemmer‐Rachamimov, Anat, Plotkin, Scott R., Wainger, Brian, Sadreyev, Ruslan I., Brenner, Gary J.

“…Schwannomas are benign neoplasms that can cause gain‐ and loss‐of‐function neurological phenotypes, including severe, intractable pain. To investigate the…”
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Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons by Brenner, Gary J., Ji, Ru-Rong, Shaffer, Sebastian, Woolf, Clifford J.

“…The N‐methyl‐D‐aspartate receptor (NMDAR) contributes to central sensitization in the spinal cord and the generation of pain hypersensitivity. NMDAR function…”
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Effect of Antibiotic Treatment on Attenuated Salmonella typhimurium VNP20009 Mediated Schwannoma Growth Control by Ahmed, Sherif G, Brenner, Gary J

“…This study evaluated the effect of enrofloxacin antibiotic treatment on the ability of an attenuated Salmonella typhimurium (S. typhimurium) strain VNP20009 to…”
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Intratumoral injection of schwannoma with attenuated Salmonella typhimurium induces antitumor immunity and controls tumor growth by Ahmed, Sherif G, Oliva, Giulia, Shao, Manlin, Wang, Xinhui, Mekalanos, John J, Brenner, Gary J

“…Schwannomas are slow-growing benign neoplasms that develop throughout the body causing pain, sensory/motor dysfunction, and death. Because bacterial…”
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