Search Results - "Brenner, Daniel G."
-
1
Modeling Student Learning Behavior Patterns in an Online Science Inquiry Environment
Published in Technology, knowledge and learning (01-10-2017)“…This study investigated how the frequency and level of assistance provided to students interacted with prior knowledge to affect learning in the Voyage to…”
Get full text
Journal Article -
2
-
3
6-(Methoxymethylene)penicillanic acid: a new .beta.-lactamase inactivator
Published in Journal of organic chemistry (01-01-1985)“…The beta -lactamase inactivator 6-(methoxymethylene)-penicillanic acid is the first compound in a new class of penams having a heteroatom-substituted methylene…”
Get full text
Journal Article -
4
Penicillanic acid sulfone: nature of irreversible inactivation of the RTEM .beta.-lactamase from Escherichia coli
Published in Biochemistry (Easton) (01-11-1984)“…When penicillanic acid sulfone in large molar excess is incubated with the RTEM beta-lactamase, the enzyme becomes inactivated irreversibly. From studies of…”
Get full text
Journal Article -
5
6-(Methoxymethylene)penicillanic acid: inactivator of RTEM .beta.-lactamase from Escherichia coli
Published in Biochemistry (Easton) (01-11-1984)“…The Z and E isomers of 6-(methoxymethylene)-penicillanic acid have been synthesized, and their interaction with the RTEM beta-lactamase has been studied. The Z…”
Get full text
Journal Article -
6
Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6.alpha.- and 6.beta.-monodeuterio and of 6,6-dideuterio derivatives with RTEM .beta.-lactamase from Escherichia coli. Crystal structure of penicillanic acid sulfone
Published in Biochemistry (Easton) (01-06-1981)Get full text
Journal Article -
7
Chloramphenicol acetyltransferase gene of staphylococcal plasmid pC221
Published in FEBS letters (01-01-1985)“…The nucleotide sequence of the inducible chloramphenicol acetyltransferase gene (cat) of Staphylococcus aureus plasmid pC221 has been determined. The deduced…”
Get full text
Journal Article -
8
Effect of recombinant neutral endopeptidase (EC 3.4.24.11) on neuropeptide-mediated nasal fluid secretion and plasma exudation in the rat
Published in American journal of rhinology (01-03-1998)“…The nasal mucosa harbors sensory nerves containing neuropeptides such as substance P (SP), which are released by capsaicin. The neuropeptides are degraded by…”
Get more information
Journal Article -
9
Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo
Published in Clinical cancer research (01-11-1998)“…Many lung cancers are stimulated by an autocrine/paracrine system of neuroendocrine peptide hormones. Attempts to block this autocrine growth pathway by…”
Get full text
Journal Article -
10
CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn Src-related kinase
Published in Blood (01-12-1996)“…CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by…”
Get full text
Journal Article -
11
Analysis of Homozygous Mutant Chimeric Mice: Deletion of the Immunoglobulin Heavy-Chain Joining Region Blocks B-Cell Development and Antibody Production
Published in Proceedings of the National Academy of Sciences - PNAS (15-03-1993)“…Using a recently described method for efficiently deriving homozygous targeted alleles in embryonic stem cells, we produced chimeric mice whose tissues were…”
Get full text
Journal Article -
12
Analysis of Mammalian Cell Genetic Regulation in situ by Using Retrovirus-Derived ``Portable Exons'' Carrying the Escherichia coli lacZ Gene
Published in Proceedings of the National Academy of Sciences - PNAS (01-07-1989)“…Self-inactivating derivatives of Moloney murine leukemia retrovirus containing the Escherichia coli lacZ gene were used to detect and study the regulation of…”
Get full text
Journal Article -
13
Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6 alpha- and 6 beta-monodeuterio and of 6,6-dideuterio derivatives with RTEM beta-lactamase from Escherichia coli
Published in Biochemistry (Easton) (23-06-1981)“…Penicillanic acid sulfone (1) is both a substrate and an inactivator of the RTEM beta-lactamase. About 7000 hydrolytic events occur before enzyme inactivation…”
Get full text
Journal Article -
14
Production of antigen-specific human antibodies from mice engineered with human heavy and light chain YACs
Published in Annals of the New York Academy of Sciences (29-09-1995)“…Our paper describes the introduction of large fragments of both the human heavy and light chain Ig genes into the mouse germline to create a mouse strain…”
Get more information
Journal Article -
15
Chloramphenicol acetyltransferase gene of staphylococcal plasmid pC221: Nucleotide sequence analysis and expression studies
Published in FEBS letters (1985)“…The nucleotide sequence of the inducible chloramphenicol acetyltransferase gene (cat) of Staphylococcus aureus plasmid pC221 has been determined. The deduced…”
Get full text
Journal Article -
16
Imino-Bridged heterocycles. V . Synthesis of 6,11-dimethyl-1 1H-benzo[5,6]cyclohepta[1,2-c]pyridin-6,11-imine by a regiospecific amide to olefin cyclization
Published in Journal of heterocyclic chemistry (01-01-1986)“…Attempted utilization of sulfenimines 6a,b to prepare tertiary carbinamines as intermediates to the desired…”
Get full text
Journal Article -
17
Imino‐Bridged heterocycles. V . Synthesis of 6,11‐dimethyl‐1 1 H ‐benzo[5,6]cyclohepta[1,2‐ c ]pyridin‐6,11‐imine by a regiospecific amide to olefin cyclization
Published in Journal of heterocyclic chemistry (01-01-1986)“…Attempted utilization of sulfenimines 6a,b to prepare tertiary carbinamines as intermediates to the desired 6,11‐dimethyl‐11 H ‐benzo[5,6]cyclohepta[1,2‐ c…”
Get full text
Journal Article -
18
Imino-bridged heterocycles. II. Regiospecific synthesis of the 11H-benzo[5,6]cyclohepta[1,2-c]pyridin-6,11-imine and 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5,10-imine systems
Published in Journal of heterocyclic chemistry (01-07-1982)“…Regiospecific synthetic pathways for two of the eight isomeric benzocycloheptapyridinimines have been developed based upon intramolecular acid catalyzed…”
Get full text
Journal Article -
19
Rapid two-stage polymerase chain reaction amplification of chromosomal DNA segments in lysates made from monolayer cultures attached to microcarrier beads
Published in Gene (1990)“…We describe a method for the rapid two-stage amplification and detection by ethidium bromide staining of chromosomal nucleotide (nt) sequences in lysates made…”
Get more information
Journal Article -
20
Imino‐bridged heterocycles. II. Regiospecific synthesis of the 11 H ‐benzo[5,6]cyclohepta[1,2‐ c ]pyridin‐6,11‐imine and 5 H ‐benzo[4,5]cyclohepta[1,2‐ b ]pyridin‐5,10‐imine systems
Published in Journal of heterocyclic chemistry (01-07-1982)“…Regiospecific synthetic pathways for two of the eight isomeric benzocycloheptapyridinimines have been developed based upon intramolecular acid catalyzed…”
Get full text
Journal Article