Search Results - "Brennen, W Nathaniel"

Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy by Brennen, W Nathaniel, Isaacs, John T, Denmeade, Samuel R

“…The tumor microenvironment has emerged as a novel chemotherapeutic strategy in the treatment of cancer. This is most clearly exemplified by the…”
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Concise Review: Mesenchymal Stem Cell‐Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise by Krueger, Timothy E. G., Thorek, Daniel L. J., Denmeade, Samuel R., Isaacs, John T., Brennen, W. Nathaniel

“…The development of mesenchymal stem cells (MSCs) as cell‐based drug delivery vectors for numerous clinical indications, including cancer, has significant…”
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Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors by Zhu, Yezi, Dalrymple, Susan L., Coleman, Ilsa, Zheng, S. Lilly, Xu, Jianfeng, Hooper, Jody E., Antonarakis, Emmanuel S., De Marzo, Angelo M., Meeker, Alan K., Nelson, Peter S., Isaacs, William B., Denmeade, Samuel R., Luo, Jun, Brennen, W. Nathaniel, Isaacs, John T.

“…The role of truncated androgen receptor splice variant-7 (AR-V7) in prostate cancer biology is an unresolved question. Is it simply a marker of resistance to…”
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Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression by Hughes, Robert M, Simons, Brian W, Khan, Hamda, Miller, Rebecca, Kugler, Valentina, Torquato, Samantha, Theodros, Debebe, Haffner, Michael C, Lotan, Tamara, Huang, Jessie, Davicioni, Elai, An, Steven S, Riddle, Ryan C, Thorek, Daniel L J, Garraway, Isla P, Fertig, Elana J, Isaacs, John T, Brennen, W Nathaniel, Park, Ben H, Hurley, Paula J

“…Tumor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of multiple cell types within the tumor microenvironment. Here…”
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Tumor‐infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer? by Krueger, Timothy E., Thorek, Daniel L. J., Meeker, Alan K., Isaacs, John T., Brennen, W. Nathaniel

“…Background Prostate cancer is characterized by T‐cell exclusion, which is consistent with their poor responses to immunotherapy. In addition, T‐cells…”
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Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug by NATHANIEL BRENNEN, W, MARC ROSEN, D, HAO WANG, ISAACS, John T, DENMEADE, Samuel R

“…Fibroblasts undergo a morphological transformation to a reactive phenotype in the tumor microenvironment characterized by the expression of proteins such as…”
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Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype by de Groot, Amber E., Myers, Kayla V., Krueger, Timothy E.G., Brennen, W. Nathaniel, Amend, Sarah R., Pienta, Kenneth J.

“…Tumor-associated macrophages (TAMs) are an abundant tumor-promoting cell type in the tumor microenvironment (TME). Most TAMs exhibit a pro-tumor M2-like…”
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The what, when, and why of human prostate cancer xenografts by Brennen, W. Nathaniel, Isaacs, John T.

“…Background Presently, ∼85 serially transplantable human prostate cancer xenografts spanning the phenotypic, epigenetic, and genetic heterogeneity seen…”
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IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry by Lu, Peng, Oetjen, Karolyn A., Bender, Diane E., Ruzinova, Marianna B., Fisher, Daniel A. C., Shim, Kevin G., Pachynski, Russell K., Brennen, W. Nathaniel, Oh, Stephen T., Link, Daniel C., Thorek, Daniel L. J.

“…Imaging Mass Cytometry (IMC) is an emerging multiplexed imaging technology for analyzing complex microenvironments using more than 40 molecularly-specific…”
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Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment by Brennen, W Nathaniel, Denmeade, Samuel R, Isaacs, John T

“…Mesenchymal stem cells (MSCs) have an inherent tropism for sites of inflammation, which are frequently present in sites of cancer, including prostatic lesions…”
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Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC by Sena, Laura A, Kumar, Rajendra, Sanin, David E, Thompson, Elizabeth A, Rosen, D Marc, Dalrymple, Susan L, Antony, Lizamma, Yang, Yuhan, Gomes-Alexandre, Carolina, Hicks, Jessica L, Jones, Tracy, Bowers, Kiara A, Eskra, Jillian N, Meyers, Jennifer, Gupta, Anuj, Skaist, Alyza, Yegnasubramanian, Srinivasan, Luo, Jun, Brennen, W Nathaniel, Kachhap, Sushant K, Antonarakis, Emmanuel S, De Marzo, Angelo M, Isaacs, John T, Markowski, Mark C, Denmeade, Samuel R

“…Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have…”
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Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment by ISAACS, John T, ANTONY, Lizamma, BJÖRK, Per, OLSSON, Anders, BJÖRK, Anders, LEANDERSON, Tomas, DALRYMPLE, Susan L, NATHANIEL BRENNEN, W, GERBER, Stephanie, HAMMERS, Hans, WISSING, Michel, KACHHAP, Sushant, JUN LUO, LI XING

“…Tasquinimod is an orally active antiangiogenic drug that is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer…”
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Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer by Kumar, Binod, Rosenberg, Avi Z., Choi, Su Mi, Fox-Talbot, Karen, De Marzo, Angelo M., Nonn, Larisa, Brennen, W. Nathaniel, Marchionni, Luigi, Halushka, Marc K., Lupold, Shawn E.

“…MiR-1 and miR-143 are frequently reduced in human prostate cancer (PCa), while miR-141 and miR-21 are frequently elevated. Consequently, these miRNAs have been…”
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Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models by Jasmine, Sumer, Mandl, Adel, Krueger, Timothy E. G., Dalrymple, Susan L., Antony, Lizamma, Dias, Jennifer, Celatka, Cassandra A., Tapper, Amy E., Kleppe, Maria, Kanayama, Mayuko, Jing, Yuezhou, Speranzini, Valentina, Wang, Yuzhuo Z., Luo, Jun, Trock, Bruce J., Denmeade, Samuel R., Carducci, Michael A., Mattevi, Andrea, Rienhoff, Hugh Y., Isaacs, John T., Brennen, W. Nathaniel

“…Introduction Lysine‐specific demethylase 1 (LSD1) is emerging as a critical mediator of tumor progression in metastatic castration‐resistant prostate cancer…”
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Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy by Denmeade, Samuel R, Mhaka, Annastasiah M, Rosen, D Marc, Brennen, W Nathaniel, Dalrymple, Susan, Dach, Ingrid, Olesen, Claus, Gurel, Bora, Demarzo, Angelo M, Wilding, George, Carducci, Michael A, Dionne, Craig A, Møller, Jesper V, Nissen, Poul, Christensen, S Brøgger, Isaacs, John T

“…Heterogeneous expression of drug target proteins within tumor sites is a major mechanism of resistance to anticancer therapies. We describe a strategy to…”
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Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin by LeBeau, Aaron M, Brennen, W Nathaniel, Aggarwal, Saurabh, Denmeade, Samuel R

“…Fibroblast-Activation Protein-α (FAP) is a membrane-bound serine protease that is expressed on the surface of reactive stromal fibroblasts present within the…”
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Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth by Lin, Jianqing, Haffner, Michael C., Zhang, Yonggang, Lee, Byron H., Brennen, W. Nathaniel, Britton, Justin, Kachhap, Sushant K., Shim, Joong Sup, Liu, Jun O., Nelson, William G., Yegnasubramanian, Srinivasan, Carducci, Michael A.

“…BACKGROUND The clinical success of the nucleoside analogs 5‐aza‐cytidine (5‐azaC) and 5‐aza‐2′deoxycytidine (5‐aza‐dC) as DNA methyltransferase (DNMT)…”
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Quantification of Mesenchymal Stem Cells (MSCs) at sites of human prostate cancer by Brennen, W Nathaniel, Chen, Shuangling, Denmeade, Samuel R, Isaacs, John T

“…Circulating bone marrow-derived Mesenchymal Stem Cells (BM-MSCs) have an innate tropism for tumor tissue in response to the inflammatory microenvironment…”
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Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy by Brennen, W Nathaniel, J Thorek, Daniel L, Jiang, Wen, Krueger, Timothy E, Antony, Lizamma, Denmeade, Samuel R, Isaacs, John T

“…The tumor microenvironment contributes to disease progression through multiple mechanisms, including immune suppression mediated in part by fibroblast…”
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A novel method for detection of exfoliated prostate cancer cells in urine by RNA in situ hybridization by Eskra, Jillian N., Rabizadeh, Daniel, Mangold, Leslie, Fabian, Elizabeth, Brennen, W. Nathaniel, Yeater, David B., Pienta, Kenneth J., Partin, Alan W., Isaacs, William B., Pavlovich, Christian P., Luo, Jun

“…Background In the current study, we explore the feasibility of detecting exfoliated prostate cancer cells in urine using an RNA in situ hybridization (RISH)…”
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