Search Results - "Brennand, K J"

Modeling psychiatric disorders at the cellular and network levels by Brennand, K J, Simone, A, Tran, N, Gage, F H

“…Although psychiatric disorders such as autism spectrum disorders, schizophrenia and bipolar disorder affect a number of brain regions and produce a complex…”
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Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1 by Stachowiak, E. K., Benson, C. A., Narla, S. T., Dimitri, A., Chuye, L. E. Bayona, Dhiman, S., Harikrishnan, K., Elahi, S., Freedman, D., Brennand, K. J., Sarder, P., Stachowiak, M. K.

“…Studies of induced pluripotent stem cells (iPSCs) from schizophrenia patients and control individuals revealed that the disorder is programmed at the…”
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Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models by Xu, J, Hartley, B J, Kurup, P, Phillips, A, Topol, A, Xu, M, Ononenyi, C, Foscue, E, Ho, S-M, Baguley, T D, Carty, N, Barros, C S, Müller, U, Gupta, S, Gochman, P, Rapoport, J, Ellman, J A, Pittenger, C, Aronow, B, Nairn, A C, Nestor, M W, Lombroso, P J, Brennand, K J

“…The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally…”
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Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients by Topol, A, English, J A, Flaherty, E, Rajarajan, P, Hartley, B J, Gupta, S, Desland, F, Zhu, S, Goff, T, Friedman, L, Rapoport, J, Felsenfeld, D, Cagney, G, Mackay-Sim, A, Savas, J N, Aronow, B, Fang, G, Zhang, B, Cotter, D, Brennand, K J

“…The genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain unresolved. Here we demonstrate, for the first time, perturbed global…”
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Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease by Kocerha, J, Dwivedi, Y, Brennand, K J

“…The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that…”
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Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease by Powell, S.K., Gregory, J., Akbarian, S., Brennand, K.J.

“…CRISPR/Cas9 technology has transformed our ability to manipulate the genome and epigenome, from efficient genomic editing to targeted localization of effectors…”
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MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice by Mitchell, A C, Javidfar, B, Pothula, V, Ibi, D, Shen, E Y, Peter, C J, Bicks, L K, Fehr, T, Jiang, Y, Brennand, K J, Neve, R L, Gonzalez-Maeso, J, Akbarian, S

“…Large-scale consortia mapping the genomic risk architectures of schizophrenia provide vast amounts of molecular information, with largely unexplored…”
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Inhibition of STEP 61 ameliorates deficits in mouse and hiPSC-based schizophrenia models by Xu, J, Hartley, B J, Kurup, P, Phillips, A, Topol, A, Xu, M, Ononenyi, C, Foscue, E, Ho, S-M, Baguley, T D, Carty, N, Barros, C S, Müller, U, Gupta, S, Gochman, P, Rapoport, J, Ellman, J A, Pittenger, C, Aronow, B, Nairn, A C, Nestor, M W, Lombroso, P J, Brennand, K J

“…The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally…”
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Dopaminergic differentiation of schizophrenia hiPSCs by Hartley, B J, Tran, N, Ladran, I, Reggio, K, Brennand, K J

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Common developmental genome deprogramming in schizophrenia — Role of Integrative Nuclear FGFR1 Signaling (INFS) by Narla, S.T, Lee, Y-W, Benson, C.A, Sarder, P, Brennand, K.J, Stachowiak, E.K, Stachowiak, M.K

“…Abstract The watershed-hypothesis of schizophrenia asserts that over 200 different mutations dysregulate distinct pathways that converge on an unspecified…”
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I wish I'd got my new ears last year, mum by Brennand, JK

“…A condition known as glue ear, otitis media with effusion, is discussed. The insertion of grommets can help improve childrens' hearing for a significant…”
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Oro-nasal transfer of nasogastric tube following endoscopic placement by Brennand, J K

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Altered proliferation and networks in neural cells derived from idiopathic autistic individuals by Marchetto, M C, Belinson, H, Tian, Y, Freitas, B C, Fu, C, Vadodaria, K C, Beltrao-Braga, P C, Trujillo, C A, Mendes, A P D, Padmanabhan, K, Nunez, Y, Ou, J, Ghosh, H, Wright, R, Brennand, K J, Pierce, K, Eichenfield, L, Pramparo, T, Eyler, L T, Barnes, C C, Courchesne, E, Geschwind, D H, Gage, F H, Wynshaw-Boris, A, Muotri, A R

“…Autism spectrum disorders (ASD) are common, complex and heterogeneous neurodevelopmental disorders. Cellular and molecular mechanisms responsible for ASD…”
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Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises by MARCHETTO, Maria C, BRENNAND, Kristen J, BOYER, Leah F, GAGE, Fred H

“…The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and…”
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Management of an unusual tongue injury by Oluwole, M, Brennand, J K

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Gene expression elucidates functional impact of polygenic risk for schizophrenia by Fromer, Menachem, Roussos, Panos, Sieberts, Solveig K, Johnson, Jessica S, Kavanagh, David H, Perumal, Thanneer M, Ruderfer, Douglas M, Oh, Edwin C, Topol, Aaron, Shah, Hardik R, Klei, Lambertus L, Kramer, Robin, Pinto, Dalila, Gümüş, Zeynep H, Cicek, A Ercument, Dang, Kristen K, Browne, Andrew, Lu, Cong, Xie, Lu, Readhead, Ben, Stahl, Eli A, Xiao, Jianqiu, Parvizi, Mahsa, Hamamsy, Tymor, Fullard, John F, Wang, Ying-Chih, Mahajan, Milind C, Derry, Jonathan M J, Dudley, Joel T, Hemby, Scott E, Logsdon, Benjamin A, Talbot, Konrad, Raj, Towfique, Bennett, David A, De Jager, Philip L, Zhu, Jun, Zhang, Bin, Sullivan, Patrick F, Chess, Andrew, Purcell, Shaun M, Shinobu, Leslie A, Mangravite, Lara M, Toyoshiba, Hiroyoshi, Gur, Raquel E, Hahn, Chang-Gyu, Lewis, David A, Haroutunian, Vahram, Peters, Mette A, Lipska, Barbara K, Buxbaum, Joseph D, Schadt, Eric E, Hirai, Keisuke, Roeder, Kathryn, Brennand, Kristen J, Katsanis, Nicholas, Domenici, Enrico, Devlin, Bernie, Sklar, Pamela

“…The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of subjects with schizophrenia ( N = 258) and control subjects ( N = 279), creating…”
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The Ombudsman and the patient's notes by Brennand, J K

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A Role for Noncoding Variation in Schizophrenia by Roussos, Panos, Mitchell, Amanda C., Voloudakis, Georgios, Fullard, John F., Pothula, Venu M., Tsang, Jonathan, Stahl, Eli A., Georgakopoulos, Anastasios, Ruderfer, Douglas M., Charney, Alexander, Okada, Yukinori, Siminovitch, Katherine A., Worthington, Jane, Padyukov, Leonid, Klareskog, Lars, Gregersen, Peter K., Plenge, Robert M., Raychaudhuri, Soumya, Fromer, Menachem, Purcell, Shaun M., Brennand, Kristen J., Robakis, Nikolaos K., Schadt, Eric E., Akbarian, Schahram, Sklar, Pamela

“…A large portion of common variant loci associated with genetic risk for schizophrenia reside within noncoding sequence of unknown function. Here, we…”
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Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes by Grochowski, Christopher M., Gu, Shen, Yuan, Bo, TCW, Julia, Brennand, Kristen J., Sebat, Jonathan, Malhotra, Dheeraj, McCarthy, Shane, Rudolph, Uwe, Lindstrand, Anna, Chong, Zechen, Levy, Deborah L., Lupski, James R., Carvalho, Claudia M.B.

“…Small supernumerary marker chromosomes (sSMC) are chromosomal fragments difficult to characterize genomically. Here, we detail a proband with schizoaffective…”
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Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions by Maury, Eduardo A, Sherman, Maxwell A, Genovese, Giulio, Gilgenast, Thomas G, Kamath, Tushar, Burris, S J, Rajarajan, Prashanth, Flaherty, Erin, Akbarian, Schahram, Chess, Andrew, McCarroll, Steven A, Loh, Po-Ru, Phillips-Cremins, Jennifer E, Brennand, Kristen J, Macosko, Evan Z, Walters, James T R, O'Donovan, Michael, Sullivan, Patrick, Sebat, Jonathan, Lee, Eunjung A, Walsh, Christopher A

“…While germline copy-number variants (CNVs) contribute to schizophrenia (SCZ) risk, the contribution of somatic CNVs (sCNVs)-present in some but not all…”
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