Search Results - "Brennan, Tracy A."

Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage by Singh, Lakshman, Brennan, Tracy A, Russell, Elizabeth, Kim, Jung-Hoon, Chen, Qijun, Brad Johnson, F, Pignolo, Robert J

“…Abstract Bone marrow derived mesenchymal progenitor cells (MPCs) play an important role in bone homeostasis. Age-related changes occur in bone resulting in a…”
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Bone histomorphometry using free and commonly available software by Egan, Kevin P, Brennan, Tracy A, Pignolo, Robert J

“…Egan K P, Brennan T A & Pignolo R J 
(2012) Histopathology
Bone histomorphometry using free and commonly available software Aims:  Histomorphometric analysis…”
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Alk2 Regulates Early Chondrogenic Fate in Fibrodysplasia Ossificans Progressiva Heterotopic Endochondral Ossification by Culbert, Andria L., Chakkalakal, Salin A., Theosmy, Edwin G., Brennan, Tracy A., Kaplan, Frederick S., Shore, Eileen M.

“…Bone morphogenetic protein (BMP) signaling is a critical regulator of cartilage differentiation and endochondral ossification. Gain‐of‐function mutations in…”
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Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP) by Brennan, Tracy A., Lindborg, Carter M., Bergbauer, Christian R., Wang, Haitao, Kaplan, Frederick S., Pignolo, Robert J.

“…Episodic flare-ups of fibrodysplasia ossificans progressiva (FOP) are characterized clinically by severe, often posttraumatic, connective tissue swelling and…”
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Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein by Aumailley, Lucie, Dubois, Marie Julie, Brennan, Tracy A., Garand, Chantal, Paquet, Eric R., Pignolo, Robert J., Marette, Andre, Lebel, Michel

“…Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ‐family DNA helicase (WRN). Mice lacking part of the helicase domain of the WRN…”
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R-spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis by Wang, Haitao, Brennan, Tracy A., Russell, Elizabeth, Kim, Jung-Hoon, Egan, Kevin P., Chen, Qijun, Israelite, Craig, Schultz, David C., Johnson, Frederick B., Pignolo, Robert J.

“…Bone tissue adapts to its functional environment by optimizing its morphology for mechanical demand. Among the mechanosensitive cells that recognize and…”
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Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis by Brennan, Tracy A, Egan, Kevin P, Lindborg, Carter M, Chen, Qijun, Sweetwyne, Mariya T, Hankenson, Kurt D, Xie, Sharon X, Johnson, Frederick B, Pignolo, Robert J

“…A major medical challenge in the elderly is osteoporosis and the high risk of fracture. Telomere dysfunction is a cause of cellular senescence and telomere…”
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Cartilage-derived retinoic acid-sensitive protein (CD-RAP): A stage-specific biomarker of heterotopic endochondral ossification (HEO) in fibrodysplasia ossificans progressiva (FOP) by Lindborg, Carter M., Brennan, Tracy A., Wang, Haitao, Kaplan, Frederick S., Pignolo, Robert J.

“…Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that…”
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Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia by Cairns, Dana M, Pignolo, Robert J, Uchimura, Tomoya, Brennan, Tracy A, Lindborg, Carter M, Xu, Meiqi, Kaplan, Frederick S, Shore, Eileen M, Zeng, Li

“…Progressive osseous heteroplasia (POH) is a rare developmental disorder of heterotopic ossification (HO) caused by heterozygous inactivating germline mutations…”
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Brief Report: Long‐Term Functional Engraftment of Mesenchymal Progenitor Cells in a Mouse Model of Accelerated Aging by Singh, Lakshman, Brennan, Tracy A., Kim, Jung‐Hoon, Egan, Kevin P., Mcmillan, Emily A., Chen, Qijun, Hankenson, Kurt D., Zhang, Yi, Emerson, Stephen G., Johnson, F. Brad, Pignolo, Robert J.

“…Age‐related osteoporosis is characterized by a decrease in bone‐forming capacity mediated by defects in the number and function of osteoblasts. An important…”
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Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging by Singh, Lakshman, Brennan, Tracy A, Kim, Jung-Hoon, Egan, Kevin P, McMillan, Emily A, Chen, Qijun, Hankenson, Kurt D, Zhang, Yi, Emerson, Stephen G, Johnson, F Brad, Pignolo, Robert J

“…Age-related osteoporosis is characterized by a decrease in bone-forming capacity mediated by defects in the number and function of osteoblasts. An important…”
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Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia by Cairns, Dana M., Pignolo, Robert J., Uchimura, Tomoya, Brennan, Tracy A., Lindborg, Carter M., Xu, Meiqi, Kaplan, Frederick S., Shore, Eileen M., Zeng, Li

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