Search Results - "Brennan, R G"

Structural Mechanisms of QacR Induction and Multidrug Recognition by Schumacher, Maria A., Miller, Marshall C., Grkovic, Steve, Brown, Melissa H., Skurray, Ronald A., Brennan, Richard G.

“…The Staphylococcus aureus multidrug binding protein QacR represses transcription of the qacA multidrug transporter gene and is induced by structurally diverse…”
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Crystal Structure of the Lactose Operon Repressor and Its Complexes with DNA and Inducer by Lewis, Mitchell, Chang, Geoffrey, Horton, Nancy C., Kercher, Michele A., Pace, Helen C., Schumacher, Maria A., Brennan, Richard G., Lu, Ponzy

“…The lac operon of Escherichia coli is the paradigm for gene regulation. Its key component is the lac repressor, a product of the lacI gene. The…”
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The helix-turn-helix DNA binding motif by Brennan, R G, Matthews, B W

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The winged-helix DNA-binding motif: another helix-turn-helix takeoff by Brennan, R G

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Crystal structure of lacI member, PurR, bound to DNA : minor groove binding by α helices by SCHUMACHER, M. A, CHOI, K. Y, ZALKIN, H, BRENNAN, R. G

“…The three-dimensional structure of a ternary complex of the purine repressor, PurR, bound to both its corepressor, hypoxanthine, and the 16-base pair purF…”
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Escherichia coli Biotin Holoenzyme Synthetase/bio Repressor Crystal Structure Delineates the Biotin- and DNA-Binding Domains by Wilson, Keith P., Shewchuk, Lisa M., Brennan, Richard G., Otsuka, Anthony J., Matthews, Brian W.

“…The three-dimensional structure of BirA, the repressor of the Escherichia coli biotin biosynthetic operon, has been determined by x-ray crystallography and…”
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The Staphylococcal QacR Multidrug Regulator Binds a Correctly Spaced Operator as a Pair of Dimers by Grkovic, S, Brown, M H, Schumacher, M A, Brennan, R G, Skurray, R A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif by Carr, D W, Stofko-Hahn, R E, Fraser, I D, Bishop, S M, Acott, T S, Brennan, R G, Scott, J D

“…The type II cAMP-dependent protein kinase is localized to specific subcellular environments through the binding of the regulatory subunit (RII) dimer to…”
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Protein-DNA Conformational Changes in the Crystal Structure of a λ Cro-Operator Complex by Brennan, Richard G., Roderick, Steven L., Takeda, Yoshinori, Matthews, Brian W.

“…The structure of a complex of bacteriophage λ Cro protein with a 17-base-pair operator has been determined at 3.9-⚬A resolution. Isomorphous derivatives…”
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Hfq: A Bacterial Sm-like Protein that Mediates RNA-RNA Interaction by Møller, Thorleif, Franch, Thomas, Højrup, Peter, Keene, Douglas R, Bächinger, Hans Peter, Brennan, Richard G, Valentin-Hansen, Poul

“…The bacterial Hfq protein modulates the stability or the translation of mRNAs and has recently been shown to interact with small regulatory RNAs in E. coli…”
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Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein by Schumacher, Maria A., Pearson, Robert F., Møller, Thorleif, Valentin-Hansen, Poul, Brennan, Richard G

“…In prokaryotes, Hfq regulates translation by modulating the structure of numerous RNA molecules by binding preferentially to A/U‐rich sequences. To elucidate…”
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Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain by Nagadoi, A, Morikawa, S, Nakamura, H, Enari, M, Kobayashi, K, Yamamoto, H, Sampei, G, Mizobuchi, K, Schumacher, MA, Brennan, RG, Nishimura, Y

“…Background: The purine repressor (PurR) regulates genes that encode enzymes for purine biosynthesis. PurR has a two domain structure with an N-terminal…”
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The Structural Mechanism for Transcription Activation by MerR Family Member Multidrug Transporter Activation, N Terminus by Newberry, Kate J, Brennan, Richard G

“…Transcription regulators of the MerR family respond to myriad stress signals to activate σ 70 /σ A -targeted genes, which contain suboptimal 19-bp spacers…”
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Prokaryotic transcription regulators: more than just the helix-turn-helix motif by Huffman, Joy L, Brennan, Richard G

“…Over the past two years, the structures of many prokaryotic transcriptional regulators have been solved, and several of them have revealed the structural…”
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Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR by Schumacher, Maria A., Miller, Marshall C., Grkovic, Steve, Brown, Melissa H., Skurray, Ronald A., Brennan, Richard G.

“…The Staphylococcus aureus multidrug‐binding protein QacR represses transcription of the qacA multidrug transporter gene and is induced by multiple structurally…”
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Secondary Structure Creates Mismatched Base Pairs Required for High- Affinity Binding of cAMP Response Element-Binding Protein to the Human Enkephalin Enhancer by Spiro, Craig, Richards, Jane P., Chandrasekaran, S., Brennan, Richard G., McMurray, Cynthia T.

“…Transactivation studies of the enkephalin enhancer indicate that two cAMP response elements (CRE-1 and CRE-2) are needed to mediate the transcriptional…”
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Crystal structure of the transcription activator BmrR bound to DNA and a drug by Brennan, Richard G, Heldwein, Ekaterina E. Zheleznova

“…The efflux of chemically diverse drugs by multidrug transporters that span the membrane is one mechanism of multidrug resistance in bacteria. The…”
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Mutational analysis of the autoinhibitory domain of calmodulin kinase II by Brickey, D A, Bann, J G, Fong, Y L, Perrino, L, Brennan, R G, Soderling, T R

“…Calmodulin (CaM)-kinase II is inactive in the absence of Ca2+/CaM due to interaction of its autoinhibitory domain with its catalytic domain. Previous studies…”
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Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors by Schumacher, Maria A., Brennan, Richard G.

“…Summary The increase in bacterial resistance to multiple drugs represents a serious and growing health risk. One component of multidrug resistance (MDR) is a…”
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Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis by Kliegman, Joseph I, Griner, Sarah L, Helmann, John D, Brennan, Richard G, Glasfeld, Arthur

“…The manganese transport regulator (MntR) of Bacillus subtilis is activated by Mn2+ to repress transcription of genes encoding transporters involved in the…”
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