Search Results - "Brennan, Paul"

drawProteins: a Bioconductor/R package for reproducible and programmatic generation of protein schematics [version 1; peer review: 2 approved] by Brennan, Paul

“…Protein schematics are valuable for research, teaching and knowledge communication. However, the tools used to automate the process are challenging. The…”
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Liquid biopsies: the future of cancer early detection by Connal, Siobhan, Cameron, James M, Sala, Alexandra, Brennan, Paul M, Palmer, David S, Palmer, Joshua D, Perlow, Haley, Baker, Matthew J

“…Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale causing emotional, physical, and financial strains on individuals,…”
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Simplifying the use of prognostic information in traumatic brain injury. Part 1: The GCS-Pupils score: an extended index of clinical severity by Brennan, Paul M, Murray, Gordon D, Teasdale, Graham M

“…Glasgow Coma Scale (GCS) scores and pupil responses are key indicators of the severity of traumatic brain damage. The aim of this study was to determine what…”
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Cell therapy for advanced liver diseases: Repair or rebuild by Dwyer, Benjamin J., Macmillan, Mark T., Brennan, Paul N., Forbes, Stuart J.

“…Advanced liver disease presents a significant worldwide health and economic burden and accounts for 3.5% of global mortality. When liver disease progresses to…”
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TargetDB: A target information aggregation tool and tractability predictor by De Cesco, Stephane, Davis, John B, Brennan, Paul E, Barchi, Joseph J

“…When trying to identify new potential therapeutic protein targets, access to data and knowledge is increasingly important. In a field where new resources and…”
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Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma by Shukla, Ruchi, Upton, Kyle R., Muñoz-Lopez, Martin, Gerhardt, Daniel J., Fisher, Malcolm E., Nguyen, Thu, Brennan, Paul M., Baillie, J. Kenneth, Collino, Agnese, Ghisletti, Serena, Sinha, Shruti, Iannelli, Fabio, Radaelli, Enrico, Dos Santos, Alexandre, Rapoud, Delphine, Guettier, Catherine, Samuel, Didier, Natoli, Gioacchino, Carninci, Piero, Ciccarelli, Francesca D., Garcia-Perez, Jose Luis, Faivre, Jamila, Faulkner, Geoffrey J.

“…LINE-1 (L1) retrotransposons are mobile genetic elements comprising ∼17% of the human genome. New L1 insertions can profoundly alter gene function and cause…”
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Targeting the Small GTPase Superfamily through Their Regulatory Proteins by Gray, Janine L., Delft, Frank, Brennan, Paul E.

“…The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches essential for numerous cellular processes. Mutations or dysregulation of these…”
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Gamma‐Glutamyl Transferase (γ‐GT) – an old dog with new tricks? by Brennan, Paul N., Dillon, John F., Tapper, Elliot B.

“…Gamma‐Glutamyl Transferase (γGT) is a key transferase involved in the transpeptidation of functional gamma‐glutamyl groups to various receptor moieties. It…”
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Somatic retrotransposition alters the genetic landscape of the human brain by Baillie, J. Kenneth, Barnett, Mark W., Upton, Kyle R., Gerhardt, Daniel J., Richmond, Todd A., De Sapio, Fioravante, Brennan, Paul M., Rizzu, Patrizia, Smith, Sarah, Fell, Mark, Talbot, Richard T., Gustincich, Stefano, Freeman, Thomas C., Mattick, John S., Hume, David A., Heutink, Peter, Carninci, Piero, Jeddeloh, Jeffrey A., Faulkner, Geoffrey J.

“…Reshaping the brain's genetic circuits Mobilization of retrotransposons, genetic elements able to move around in the genome where they can become incorporated…”
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Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion by Gangoso, Ester, Southgate, Benjamin, Bradley, Leanne, Rus, Stefanie, Galvez-Cancino, Felipe, McGivern, Niamh, Güç, Esra, Kapourani, Chantriolnt-Andreas, Byron, Adam, Ferguson, Kirsty M., Alfazema, Neza, Morrison, Gillian, Grant, Vivien, Blin, Carla, Sou, IengFong, Marques-Torrejon, Maria Angeles, Conde, Lucia, Parrinello, Simona, Herrero, Javier, Beck, Stephan, Brandner, Sebastian, Brennan, Paul M., Bertone, Paul, Pollard, Jeffrey W., Quezada, Sergio A., Sproul, Duncan, Frame, Margaret C., Serrels, Alan, Pollard, Steven M.

“…Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms…”
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Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer by Butler, Holly J., Brennan, Paul M., Cameron, James M., Finlayson, Duncan, Hegarty, Mark G., Jenkinson, Michael D., Palmer, David S., Smith, Benjamin R., Baker, Matthew J.

“…Non-specific symptoms, as well as the lack of a cost-effective test to triage patients in primary care, has resulted in increased time-to-diagnosis and a poor…”
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Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane by Frank, Nils, Nugent, Jeremy, Shire, Bethany R., Pickford, Helena D., Rabe, Patrick, Sterling, Alistair J., Zarganes-Tzitzikas, Tryfon, Grimes, Thomas, Thompson, Amber L., Smith, Russell C., Schofield, Christopher J., Brennan, Paul E., Duarte, Fernanda, Anderson, Edward A.

“…Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly found para -substituted benzene rings in drug design 1 . The…”
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Assessment of level of consciousness using Glasgow Coma Scale tools by Brennan, Paul M, Whittingham, Charlotte, Sinha, Virendra Deo, Teasdale, Graham

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Ubiquitous L1 Mosaicism in Hippocampal Neurons by Upton, Kyle R., Gerhardt, Daniel J., Jesuadian, J. Samuel, Richardson, Sandra R., Sánchez-Luque, Francisco J., Bodea, Gabriela O., Ewing, Adam D., Salvador-Palomeque, Carmen, van der Knaap, Marjo S., Brennan, Paul M., Vanderver, Adeline, Faulkner, Geoffrey J.

“…Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source of genotypic variation among neurons. As a neurogenic niche, the hippocampus…”
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RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain by Picaud, Sarah, Wells, Christopher, Felletar, Ildiko, Brotherton, Deborah, Martin, Sarah, Savitsky, Pavel, Diez-Dacal, Beatriz, Philpott, Martin, Bountra, Chas, Lingard, Hannah, Fedorov, Oleg, Müller, Susanne, Brennan, Paul E., Knapp, Stefan, Filippakopoulos, Panagis

“…Bromodomains have emerged as attractive candidates for the development of inhibitors targeting gene transcription. Inhibitors of the bromo and extraterminal…”
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Letter to the Editor: Future-proofing transplant hepatology training: Shared learnings from "across the pond" by Li, Wenhao, Brennan, Paul N, Tavabie, Oliver D

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Recent Progress in Histone Demethylase Inhibitors by McAllister, Tom E, England, Katherine S, Hopkinson, Richard J, Brennan, Paul E, Kawamura, Akane, Schofield, Christopher J

“…There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target…”
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Investigating centrifugal filtration of serum-based FTIR spectroscopy for the stratification of brain tumours by Theakstone, Ashton G, Brennan, Paul M, Jenkinson, Michael D, Goodacre, Royston, Baker, Matthew J

“…Discrimination of brain cancer versus non-cancer patients using serum-based attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy…”
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Approved and investigational fluorescent optical imaging agents for disease detection in surgery by Rehman, Sonia, Brennan, Paul, Lilienkampf, Annamaria, Bradley, Mark

“…Fluorescent optical imaging is becoming an increasingly attractive imaging tool that physicians can utilise as it can detect previously 'unseen' changes in…”
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Analytic approaches to clinical validation of results from preclinical models of glioblastoma: A systematic review by Fitt, Beth, Loy, Grace, Christopher, Edward, Brennan, Paul M, Poon, Michael Tin Chung

“…Analytic approaches to clinical validation of results from preclinical models are important in assessment of their relevance to human disease. This systematic…”
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