Search Results - "Brennan, Kieran"

Investigation of canine extracellular vesicles in diffuse large B-cell lymphomas by Kulka, Marek, Brennan, Kieran, Mc Gee, Margaret

“…Diffuse large B-cell lymphomas (DLBCLs) are the most common lymphoproliferative diseases in dogs. DLBCL diagnosis to date has relied on histopathological…”
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Cyclophilin A Isomerisation of Septin 2 Mediates Abscission during Cytokinesis by Gorry, Rebecca L, Brennan, Kieran, Lavin, Paul T M, Mazurski, Tayler, Mary, Charline, Matallanas, David, Guichou, Jean-François, Mc Gee, Margaret M

“…The isomerase activity of Cyclophilin A is important for midbody abscission during cell division, however, to date, midbody substrates remain unknown. In this…”
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Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase by McSherry, Elaine A, Brennan, Kieran, Hudson, Lance, Hill, Arnold D K, Hopkins, Ann M

“…The adhesion protein junctional adhesion molecule-A (JAM-A) regulates epithelial cell morphology and migration, and its over-expression has recently been…”
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A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer by Cruz, Rodrigo G B, Madden, Stephen F, Brennan, Kieran, Hopkins, Ann M

“…Overexpression of the human epidermal growth factor receptor-2 (HER2) is associated with aggressive disease in breast and certain other cancers. At a cellular…”
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Cyclophilin A regulates secretion of tumour-derived extracellular vesicles by Wu, Yunjie, Brennan, Kieran, Fernández, Alfonso Blanco, Mc Gee, Margaret M.

“…•Blood cancer EVs stimulate pro-inflammatory immune signals.•Cyclophilin A is a core EV protein and is localised in high density blood cancer derived…”
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ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis by Charmsaz, Sara, Doherty, Ben, Cocchiglia, Sinéad, Varešlija, Damir, Marino, Attilio, Cosgrove, Nicola, Marques, Ricardo, Priedigkeit, Nolan, Purcell, Siobhan, Bane, Fiona, Bolger, Jarlath, Byrne, Christopher, O'Halloran, Philip J, Brett, Francesca, Sheehan, Katherine, Brennan, Kieran, Hopkins, Ann M, Keelan, Stephen, Jagust, Petra, Madden, Stephen, Martinelli, Chiara, Battaglini, Matteo, Oesterreich, Steffi, Lee, Adrian V, Ciofani, Gianni, Hill, Arnold D K, Young, Leonie S

“…Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis is a common and devastating site of relapse for several breast…”
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Classification of diffuse light emission profiles for distinguishing skin layer penetration of a needle-free jet injection by Brennan, Kieran A., Ruddy, Bryan P., Nielsen, Poul M. F., Taberner, Andrew J.

“…In this work, a system is developed for tracking the skin layer to which a needle-free jet injection of fluid has penetrated by incorporating a laser beam into…”
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Spatially resolved diffuse imaging for high‐speed depth estimation of jet injection by Brennan, Kieran A., Ruddy, Bryan P., Nielsen, Poul M. F., Taberner, Andrew J.

“…We investigate the use of spatially resolved diffuse imaging to track a fluid jet delivered at high speed into skin tissue. A jet injector with a short needle…”
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Extracellular Vesicles Isolated from Plasma of Multiple Myeloma Patients Treated with Daratumumab Express CD38, PD-L1, and the Complement Inhibitory Proteins CD55 and CD59 by Brennan, Kieran, Iversen, Katrine F, Blanco-Fernández, Alfonso, Lund, Thomas, Plesner, Torben, Mc Gee, Margaret M

“…Daratumumab (DARA) has improved the outcome of treatment of multiple myeloma (MM). DARA acts via complement-dependent and -independent mechanisms. Resistance…”
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High-speed X-ray analysis of liquid delivery during jet injection by Mckeage, James W., Brennan, Kieran A., Geehoon Park, Hogan, N. Catherine, Hunter, Ian W., Ruddy, Bryan P., Nielsen, Poul M. F., Taberner, Andrew J.

“…The effect of varying velocity during jet injection on the dispersion of fluid into tissue is investigated using a custom-built X-ray imaging system…”
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Investigation of canine extracellular vesicles in diffuse large B-cell lymphomas by Marek Kulka, Kieran Brennan, Margaret Mc Gee

“…Diffuse large B-cell lymphomas (DLBCLs) are the most common lymphoproliferative diseases in dogs. DLBCL diagnosis to date has relied on histopathological…”
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Phosphorylation of the prolyl isomerase Cyclophilin A regulates its localisation and release from the centrosome during mitosis by Gorry, Rebecca, Brennan, Kieran, Lavin, Paul TM, Sheridan, Rebecca, Mc Gee, Margaret M

“…The centrosome acts as a protein platform from which proteins are deployed to function throughout the cell cycle. Previously, we have shown that the prolyl…”
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Isolation and Characterization of Human Conjunctival Mesenchymal Stromal Cells and Their Extracellular Vesicles by García-Posadas, Laura, Romero-Castillo, Ismael, Brennan, Kieran, Mc Gee, Margaret M., Blanco-Fernández, Alfonso, Diebold, Yolanda

“…PurposeThe purpose of this study was to isolate and culture human conjunctival mesenchymal stromal cells (Conj-MSCs) from cadaveric donor tissue, and to obtain…”
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Light source depth estimation in porcine skin using spatially resolved diffuse imaging by Brennan, Kieran A., Ruddy, Bryan P., Nielsen, Poul M. F., Taberner, Andrew J.

“…We present an inexpensive imaging system for measuring the diffuse surface radiance profile produced by a light source within a turbid medium. The diffusion…”
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Abstract 4025: An old foe with a new function: JAM-A regulates expression of EphB4 and inhibitor of apoptosis proteins in breast cancer by Vellanki, Sri HariKrishna, Cruz, Rodrigo G., Richards, Cathy E., Brennan, Kieran, Hopkins, Ann M.

“…Abstract Over-expression of Junctional Adhesion Molecule-A (JAM-A) in breast tumors has been linked with increased risk of metastasis. Since JAM-A is…”
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Multiple Myeloma Derived Extracellular Vesicle Uptake by Monocyte Cells Stimulates IL-6 and MMP-9 Secretion and Promotes Cancer Cell Migration and Proliferation by Sheridan, Rebecca, Brennan, Kieran, Bazou, Despina, O'Gorman, Peter, Matallanas, David, Mc Gee, Margaret M

“…Multiple Myeloma (MM) is an incurable haematological malignancy caused by uncontrolled growth of plasma cells. MM pathogenesis is attributed to crosstalk…”
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Abstract P3-06-01: Junctional adhesion molecule-A (JAM-A) as a novel future drug target in ductal carcinoma in situ (DCIS) by Hopkins, Ann M, Smith, Yvonne E., Wang, Guannan, Flynn, Ciara, Casucci, Alexander, Vellanki, Sri HariKrishna, Hudson, Lance, Brennan, Kieran, Cremona, Mattia, Sukumar, Saraswati

“…Abstract Background/Aim: Increased expression of the cell-cell adhesion molecule Junctional Adhesion Molecule-A (JAM-A) has been associated with poor prognosis…”
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Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects by Casey, Jillian P, Brennan, Kieran, Scheidel, Noemie, McGettigan, Paul, Lavin, Paul T, Carter, Stephen, Ennis, Sean, Dorkins, Huw, Ghali, Neeti, Blacque, Oliver E, Mc Gee, Margaret M, Murphy, Helen, Lynch, Sally Ann

“…Skeletal dysplasias are a clinically and genetically heterogeneous group of bone and cartilage disorders. Whilst >450 skeletal dysplasias have been reported,…”
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Tight Junctions : A Barrier to the Initiation and Progression of Breast Cancer? by Brennan, Kieran, Offiah, Gozie, McSherry, Elaine A., Hopkins, Ann M.

“…Breast cancer is a complex and heterogeneous disease that arises from epithelial cells lining the breast ducts and lobules. Correct adhesion between adjacent…”
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Human Epidermal Growth Factor Receptor-3 Expression Is Regulated at Transcriptional Level in Breast Cancer Settings by Junctional Adhesion Molecule-A via a Pathway Involving Beta-Catenin and FOXA1 by Cruz, Rodrigo G B, Madden, Stephen F, Richards, Cathy E, Vellanki, Sri HariKrishna, Jahns, Hanne, Hudson, Lance, Fay, Joanna, O'Farrell, Naoimh, Sheehan, Katherine, Jirström, Karin, Brennan, Kieran, Hopkins, Ann M

“…The success of breast cancer therapies targeting the human epidermal growth factor receptor-2 (HER2) is limited by the development of drug resistance by…”
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