Search Results - "Brennan, Gary P."

Epigenetic principles underlying epileptogenesis and epilepsy syndromes by Conboy, Karen, Henshall, David C., Brennan, Gary P.

“…Epilepsy is a network disorder driven by fundamental changes in the function of the cells which compose these networks. Driving this aberrant cellular function…”
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Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease by Mathoux, Justine, Henshall, David C., Brennan, Gary P.

“…RNA modifications have emerged as an additional layer of regulatory complexity governing the function of almost all species of RNA. N 6 -methyladenosine (m 6…”
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Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks by Brennan, Gary P., Dey, Deblina, Chen, Yuncai, Patterson, Katelin P., Magnetta, Eric J., Hall, Alicia M., Dube, Celine M., Mei, Yu-Tang, Baram, Tallie Z.

“…Insult-provoked transformation of neuronal networks into epileptic ones involves multiple mechanisms. Intervention studies have identified both dysregulated…”
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CHD2-Related CNS Pathologies by Wilson, Marc-Michel, Henshall, David C, Byrne, Susan M, Brennan, Gary P

“…Epileptic encephalopathies (EE) are severe epilepsy syndromes characterized by multiple seizure types, developmental delay and even regression. This class of…”
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A microRNA‐129‐5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses by Rajman, Marek, Metge, Franziska, Fiore, Roberto, Khudayberdiev, Sharof, Aksoy‐Aksel, Ayla, Bicker, Silvia, Ruedell Reschke, Cristina, Raoof, Rana, Brennan, Gary P, Delanty, Norman, Farrell, Michael A, O'Brien, Donncha F, Bauer, Sebastian, Norwood, Braxton, Veno, Morten T, Krüger, Marcus, Braun, Thomas, Kjems, Jørgen, Rosenow, Felix, Henshall, David C, Dieterich, Christoph, Schratt, Gerhard

“…Synaptic downscaling is a homeostatic mechanism that allows neurons to reduce firing rates during chronically elevated network activity. Although synaptic…”
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Editorial: The molecular mechanisms of epilepsy and potential therapeutics by Engel, Tobias, Brennan, Gary P, Soreq, Hermona

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Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy by Brennan, Gary P., Bauer, Sebastian, Engel, Tobias, Jimenez-Mateos, Eva M., Del Gallo, Federico, Hill, Thomas D.M., Connolly, Niamh M.C., Costard, Lara S., Neubert, Valentin, Salvetti, Beatrice, Sanz-Rodriguez, Amaya, Heiland, Mona, Mamad, Omar, Brindley, Elizabeth, Norwood, Braxton, Batool, Aasia, Raoof, Rana, El-Naggar, Hany, Reschke, Cristina R., Delanty, Norman, Prehn, Jochen H.M., Fabene, Paolo, Mooney, Catherine, Rosenow, Felix, Henshall, David C.

“…Epilepsy diagnosis is complex, requires a team of specialists and relies on in-depth patient and family history, MRI-imaging and EEG monitoring. There is…”
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The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes by McClelland, Shawn, Brennan, Gary P, Dubé, Celine, Rajpara, Seeta, Iyer, Shruti, Richichi, Cristina, Bernard, Christophe, Baram, Tallie Z

“…The mechanisms generating epileptic neuronal networks following insults such as severe seizures are unknown. We have previously shown that interfering with the…”
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Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy by Raoof, Rana, Bauer, Sebastian, El Naggar, Hany, Connolly, Niamh M.C., Brennan, Gary P., Brindley, Elizabeth, Hill, Thomas, McArdle, Hazel, Spain, Elaine, Forster, Robert J., Prehn, Jochen H.M., Hamer, Hajo, Delanty, Norman, Rosenow, Felix, Mooney, Catherine, Henshall, David C.

“…There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong…”
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Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis by McKiernan, Ross C, Jimenez-Mateos, Eva M, Bray, Isabella, Engel, Tobias, Brennan, Gary P, Sano, Takanori, Michalak, Zuzanna, Moran, Catherine, Delanty, Norman, Farrell, Michael, O'Brien, Donncha, Meller, Robert, Simon, Roger P, Stallings, Raymond L, Henshall, David C

“…Hippocampal sclerosis (HS) is a common pathological finding in patients with temporal lobe epilepsy (TLE) and is associated with altered expression of genes…”
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MicroRNA Profiling Shows a Time-Dependent Regulation within the First 2 Months Post-Birth and after Mild Neonatal Hypoxia in the Hippocampus from Mice by Leavy, Aisling, Brennan, Gary P, Jimenez-Mateos, Eva M

“…Brain development occurs until adulthood, with time-sensitive processes happening during embryo development, childhood, and puberty. During early life and…”
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Multiple Disruptions of Glial-Neuronal Networks in Epileptogenesis That Follows Prolonged Febrile Seizures by Brennan, Gary P, Garcia-Curran, Megan M, Patterson, Katelin P, Luo, Renhao, Baram, Tallie Z

“…Bi-directional neuronal-glial communication is a critical mediator of normal brain function and is disrupted in the epileptic brain. The potential role of…”
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Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy by Brindley, Elizabeth, Heiland, Mona, Mooney, Catherine, Diviney, Mairead, Mamad, Omar, Hill, Thomas D M, Yan, Yan, Venø, Morten T, Reschke, Cristina R, Batool, Aasia, Langa, Elena, Sanz-Rodriguez, Amaya, Heller, Janosch P, Morris, Gareth, Conboy, Karen, Kjems, Jørgen, Brennan, Gary P, Henshall, David C

“…The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as…”
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Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus by Batool, Aasia, Hill, Thomas D M, Nguyen, Ngoc T, Langa, Elena, Diviney, Mairéad, Mooney, Catherine, Brennan, Gary P, Connolly, Niamh M C, Sanz-Rodriguez, Amaya, Cavanagh, Brenton L, Henshall, David C

“…Repetitive or prolonged seizures (status epilepticus) can damage neurons within the hippocampus, trigger gliosis, and generate an enduring state of…”
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Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo by Brennan, Gary P, Jimenez-Mateos, Eva M, McKiernan, Ross C, Engel, Tobias, Tzivion, Guri, Henshall, David C

“…14-3-3 proteins are ubiquitous molecular chaperones that are abundantly expressed in the brain where they regulate cell functions including metabolism, the…”
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Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice by Almeida Silva, Luiz F, Reschke, Cristina R, Nguyen, Ngoc T, Langa, Elena, Sanz-Rodriguez, Amaya, Gerbatin, Rogerio R, Temp, Fernanda R, de Freitas, Mayara L, Conroy, Ronan M, Brennan, Gary P, Engel, Tobias, Henshall, David C

“…Abstract MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. Sequencing as well as functional studies using antisense…”
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A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force by van Vliet, Erwin A, Hildebrand, Michael S, Mills, James D, Brennan, Gary P, Eid, Tore, Masino, Susan A, Whittemore, Vicky, Bindila, Laura, Wang, Kevin K, Patel, Manisha, Perucca, Piero, Reid, Christopher A

“…The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create…”
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RNA-sequencing analysis of umbilical cord plasma microRNAs from healthy newborns by Brennan, Gary P, Vitsios, Dimitrios M, Casey, Sophie, Looney, Ann-Marie, Hallberg, Boubou, Henshall, David C, Boylan, Geraldine B, Murray, Deirdre M, Mooney, Catherine

“…MicroRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. MicroRNAs have been identified in various body…”
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MicroRNAs as regulators of brain function and targets for treatment of epilepsy by Brennan, Gary P., Henshall, David C.

“…Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the primary clinical symptom of the epilepsies. Brain tissue from animal…”
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Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis by Patterson, Katelin P, Brennan, Gary P, Curran, Megan, Kinney-Lang, Eli, Dubé, Celine, Rashid, Faisal, Ly, Catherine, Obenaus, Andre, Baram, Tallie Z

“…Epilepsy is a common neurological disorder with many causes. For temporal lobe epilepsy, antecedent insults are typically found. These risk factors include…”
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