Search Results - "Brennan, Christopher M"

p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets by Brennan, Christopher M, Emerson, Jr, Charles P, Owens, Jane, Christoforou, Nicolas

“…p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38…”
Get full text

DUX4 expression activates JNK and p38 MAP kinases in myoblasts by Brennan, Christopher M., Hill, Abby S., St. Andre, Michael, Li, Xianfeng, Madeti, Vijaya, Breitkopf, Susanne, Garren, Seth, Xue, Liang, Gilbert, Tamara, Hadjipanayis, Angela, Monetti, Mara, Emerson, Charles P., Moccia, Robert, Owens, Jane, Christoforou, Nicolas

“…Facioscapulohumeral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results in transcriptional…”
Get full text

Reduced heme levels underlie the exponential growth defect of the Shewanella oneidensis hfq mutant by Brennan, Christopher M, Mazzucca, Nicholas Q, Mezoian, Taylor, Hunt, Taylor M, Keane, Meaghan L, Leonard, Jessica N, Scola, Shelby E, Beer, Emma N, Perdue, Sarah, Pellock, Brett J

“…The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing…”
Get full text

HuR Binding to Cytoplasmic mRNA Is Perturbed by Heat Shock by Gallouzi, Imed-Eddine, Brennan, Christopher M., Stenberg, Myrna G., Swanson, Maurice S., Eversole, Ashley, Maizels, Nancy, Steitz, Joan A.

“…AU-rich elements (AREs) located in the 3′untranslated region target the mRNAs encoding many protooncoproteins, cytokines, and lymphokines for rapid…”
Get full text

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells by Brennan, Christopher M, Vaites, Laura Pontano, Wells, Jonathan N, Santaguida, Stefano, Paulo, Joao A, Storchova, Zuzana, Harper, J Wade, Marsh, Joseph A, Amon, Angelika

“…Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein…”
Get full text

Aneuploidy Causes Non-genetic Individuality by Beach, Rebecca R., Ricci-Tam, Chiara, Brennan, Christopher M., Moomau, Christine A., Hsu, Pei-hsin, Hua, Bo, Silberman, Rebecca E., Springer, Michael, Amon, Angelika

“…Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and cancer. Allelic variances have been thought…”
Get full text

Shewanella oneidensis Hfq promotes exponential phase growth, stationary phase culture density, and cell survival by Brennan, Christopher M, Keane, Meghan L, Hunt, Taylor M, Goulet, Matthew T, Mazzucca, Nicholas Q, Sexton, Zachary, Mezoian, Taylor, Douglas, Katherine E, Osborn, Jessica M, Pellock, Brett J

“…Hfq is an RNA chaperone protein that has been broadly implicated in sRNA function in bacteria. Here we describe the construction and characterization of a null…”
Get full text

Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response by Kane, Andrew J, Brennan, Christopher M, Xu, Acer E, Solís, Eric J, Terhorst, Allegra, Denic, Vladimir, Amon, Angelika

“…Aneuploid yeast cells are in a chronic state of proteotoxicity, yet do not constitutively induce the cytosolic unfolded protein response, or heat shock…”
Get full text

Protein Ligands to HuR Modulate Its Interaction with Target mRNAs in Vivo by Brennan, Christopher M., Gallouzi, Imed-Eddine, Steitz, Joan A.

“…AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene, cytokine, and lymphokine messages target them for rapid degradation. HuR,…”
Get full text

Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation by Brennan, Christopher M., Atkins, Kristen A., Druzgal, Colleen H., Gaskin, Cree M.

“…Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low…”
Get full text

Sonographic imaging of the posterior fossa utilizing the foramen magnum by Brennan, Christopher M., Taylor, George A.

“…In this essay, we describe our experience with a sonographic technique utilizing the foramen magnum to more clearly define anatomy in the neonatal posterior…”
Get full text

Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock by GALLOUZI, IMED-EDDINE, BRENNAN, CHRISTOPHER M., STEITZ, JOAN A.

“…AU-rich elements (AREs) located in the 3′ UTRs of the messenger RNAs (mRNAs) of many mammalian early response genes promote rapid mRNA turnover. HuR, an…”
Get full text

Shewanella oneidensisHfq promotes exponential phase growth, stationary phase culture density, and cell survival by Brennan, Christopher M, Keane, Meghan L, Hunt, Taylor M, Goulet, Matthew T, Mazzucca, Nicholas Q, Sexton, Zachary, Mezoian, Taylor, Douglas, Katherine E, Osborn, Jessica M, Pellock, Brett J

Get full text

Reduced Heme Levels Underlie the Exponential Growth Defect of the Shewanella oneidensis hfq Mutant: e109879 by Brennan, Christopher M, Mazzucca, Nicholas Q, Mezoian, Taylor, Hunt, Taylor M, Keane, Meaghan L, Leonard, Jessica N, Scola, Shelby E, Beer, Emma N, Perdue, Sarah, Pellock, Brett J

“…The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing…”
Get full text

The combat position: achieving firefighting readiness by Brennan, Christopher

Get full text

Imaging Evaluation of the Rotator Cuff by Anderson, Mark W., MD, Brennan, Christopher, MD, Mittal, Amit, MD

“…The rotator cuff is a complex network of interwoven tendons that plays a key role in glenohumeral movement and stability. Cuff abnormality is a common source…”
Get full text