Search Results - "Brenkman, Arjan B."

Current methods in quantifying ROS and oxidative damage in Caenorhabditis elegans and other model organism of aging by Labuschagne, Christiaan F, Brenkman, Arjan B

“…Highlights • The role of ROS in aging is currently under heavy debate. • Methodological difficulties hamper the understanding of the role of ROS in aging. • C…”
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Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity by van Loosdregt, Jorg, Fleskens, Veerle, Fu, Juan, Brenkman, Arjan B., Bekker, Cornelis P.J., Pals, Cornelieke E.G.M., Meerding, Jenny, Berkers, Celia R., Barbi, Joseph, Gröne, Andrea, Sijts, Alice J.A.M., Maurice, Madelon M., Kalkhoven, Eric, Prakken, Berent J., Ovaa, Huib, Pan, Fan, Zaiss, Dietmar M.W., Coffer, Paul J.

“…Stable Foxp3 expression is required for the development of functional regulatory T (Treg) cells. Here, we demonstrate that the expression of the transcription…”
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Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization by van Loosdregt, Jorg, Vercoulen, Yvonne, Guichelaar, Teun, Gent, Yoony Y.J., Beekman, Jeffrey M., van Beekum, Olivier, Brenkman, Arjan B., Hijnen, Dirk-Jan, Mutis, Tuna, Kalkhoven, Eric, Prakken, Berent J., Coffer, Paul J.

“…Regulatory T cells (Tregs) are a specific subset of lymphocytes that are critical for the maintenance of self-tolerance. Expression levels of the transcription…”
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Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages by Kranendonk, Mariëtte E.G., Visseren, Frank L.J., Balkom, Bas W.M., Nolte‐'t Hoen, Esther N.M., Herwaarden, Joost A., Jager, Wilco, Schipper, Henk S., Brenkman, Arjan B., Verhaar, Marianne C., Wauben, Marca H.M., Kalkhoven, Eric

“…Objective Extracellular vesicles (EVs) released by human adipocytes or adipose tissue (AT)‐explants play a role in the paracrine interaction between adipocytes…”
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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP by Burgering, Boudewijn M.T, van der Horst, Armando, de Vries-Smits, Alida M.M, Brenkman, Arjan B, van Triest, Miranda H, van den Broek, Niels, Colland, Frédéric, Maurice, Madelon M

“…FOXO (Forkhead box O) transcription factors are important regulators of cellular metabolism, cell-cycle progression and cell death. FOXO activity is regulated…”
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A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension by Essers, Paul B., Nonnekens, Julie, Goos, Yvonne J., Betist, Marco C., Viester, Marjon D., Mossink, Britt, Lansu, Nico, Korswagen, Hendrik C., Jelier, Rob, Brenkman, Arjan B., MacInnes, Alyson W.

“…The biogenesis of ribosomes and their coordination of protein translation consume an enormous amount of cellular energy. As such, it has been established that…”
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Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1 by Lebbink, Robert Jan, de Ruiter, Talitha, Adelmeijer, Jelle, Brenkman, Arjan B, van Helvoort, Joop M, Koch, Manuel, Farndale, Richard W, Lisman, Ton, Sonnenberg, Arnoud, Lenting, Peter J, Meyaard, Linde

“…Collagens are the most abundant proteins in the human body, important in maintenance of tissue structure and hemostasis. Here we report that collagens are high…”
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Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment by Jelluma, Nannette, Brenkman, Arjan B., van den Broek, Niels J.F., Cruijsen, Carin W.A., van Osch, Maria H.J., Lens, Susanne M.A., Medema, René H., Kops, Geert J.P.L.

“…Maintenance of chromosomal stability relies on coordination between various processes that are critical for proper chromosome segregation in mitosis. Here we…”
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Electric Pulse Stimulation of Myotubes as an In Vitro Exercise Model: Cell-Mediated and Non-Cell-Mediated Effects by Evers-van Gogh, Inkie J.A., Alex, Sheril, Stienstra, Rinke, Brenkman, Arjan B., Kersten, Sander, Kalkhoven, Eric

“…Regular exercise has emerged as one of the best therapeutic strategies to prevent and treat type-2-diabetes. Exercise-induced changes in the muscle secretome,…”
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Endometriosis is associated with aberrant metabolite profiles in plasma by Letsiou, Sophia, Ph.D, Peterse, Dirkje P., M.Sc, Fassbender, Amelie, Ph.D, Hendriks, Margriet M., Ph.D, van den Broek, Niels J., B.Sc, Berger, Rudolf, M.D, O, Dorien F., M.Sc, Vanhie, Arne, M.D, Vodolazkaia, Alexandra, M.D., Ph.D, Van Langendonckt, Anne, M.D., Ph.D, Donnez, Jacques, M.D., Ph.D, Harms, Amy C., Ph.D, Vreeken, Rob J., Ph.D, Groothuis, Patrick G., Ph.D, Dolmans, Marie-Madeleine, M.D., Ph.D, Brenkman, Arjan B., Ph.D, D'Hooghe, Thomas M., M.D., Ph.D

“…Objective To identify metabolites that are associated with and predict the presence of endometriosis. Design Metabolomics study using state-of-the-art mass…”
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Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism by Stout, Gerdine J, Stigter, Edwin C A, Essers, Paul B, Mulder, Klaas W, Kolkman, Annemieke, Snijders, Dorien S, van den Broek, Niels J F, Betist, Marco C, Korswagen, Hendrik C, MacInnes, Alyson W, Brenkman, Arjan B

“…Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1) pathway double the lifespan of the nematode Caenorhabditis elegans …”
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The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity by Tasdelen, Ismayil, van Beekum, Olivier, Gorbenko, Olena, Fleskens, Veerle, van den Broek, Niels J F, Koppen, Arjen, Hamers, Nicole, Berger, Ruud, Coffer, Paul J, Brenkman, Arjan B, Kalkhoven, Eric

“…Reversible phosphorylation is a widespread molecular mechanism to regulate the function of cellular proteins, including transcription factors. Phosphorylation…”
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Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A by Bovenschen, Niels, Quadir, Razi, van den Berg, A. Lotte, Brenkman, Arjan B., Vandenberghe, Isabel, Devreese, Bart, Joore, Jos, Kummer, J. Alain

“…Granzymes are serine proteases stored in cytolytic granules of cytotoxic lymphocytes that eliminate virus-infected and tumor cells. Little is known about the…”
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A protocol for quantifying lipid peroxidation in cellular systems by F2-isoprostane analysis by Labuschagne, Christiaan F, van den Broek, Niels J F, Postma, Pjotr, Berger, Ruud, Brenkman, Arjan B

“…Cellular systems are essential model systems to study reactive oxygen species and oxidative damage but there are widely accepted technical difficulties with…”
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Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3‐isoprostane measurement by Labuschagne, Christiaan F., Stigter, Edwin C. A., Hendriks, Margriet M. W. B., Berger, Ruud, Rokach, Joshua, Korswagen, Hendrik C., Brenkman, Arjan B.

“…Summary Oxidative damage is thought to be a major cause in development of pathologies and aging. However, quantification of oxidative damage is…”
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SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner by van Gent, Rogier, Di Sanza, Claudio, van den Broek, Niels J F, Fleskens, Veerle, Veenstra, Aukje, Stout, Gerdine J, Brenkman, Arjan B

“…The Forkhead transcription factor FOXA2 plays a fundamental role in controlling metabolic homeostasis in the liver during fasting. The precise molecular…”
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Mdm2 induces mono-ubiquitination of FOXO4 by Brenkman, Arjan B, de Keizer, Peter L J, van den Broek, Niels J F, Jochemsen, A G, Burgering, Boudewijn M Th

“…The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and…”
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Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes by Jelluma, Nannette, Brenkman, Arjan B, McLeod, Ian, Yates, 3rd, John R, Cleveland, Don W, Medema, René H, Kops, Geert J P L

“…Chromosomal instability (CIN), a feature widely shared by cells from solid tumors, is caused by occasional chromosome missegregations during cell division. Two…”
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Phosphorylation of Not4p Functions Parallel to BUR2 to Regulate Resistance to Cellular Stresses in Saccharomyces cerevisiae by Lau, Nga-Chi, Mulder, Klaas W, Brenkman, Arjan B, Mohammed, Shabaz, Broek, Niels J.F. van den, Heck, Albert J.R, Timmers, H.Th. Marc

“…Background: The evolutionarily conserved Ccr4-Not and Bur1/2 kinase complexes are functionally related in Saccharomyces cerevisiae. In this study, we further…”
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The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis by Kress, Theresia R., Cannell, Ian G., Brenkman, Arjan B., Samans, Birgit, Gaestel, Matthias, Roepman, Paul, Burgering, Boudewijn M., Bushell, Martin, Rosenwald, Andreas, Eilers, Martin

“…Expression of the Myc oncoprotein is downregulated in response to stress signals to allow cells to cease proliferation and escape apoptosis, but the mechanisms…”
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