Search Results - "Brenière, Manon"

Catalytically inactive DNA ligase IV promotes DNA repair in living cells by Goff, Noah J, Brenière, Manon, Buehl, Christopher J, de Melo, Abinadabe J, Huskova, Hana, Ochi, Takashi, Blundell, Tom L, Mao, Weifeng, Yu, Kefei, Modesti, Mauro, Meek, Katheryn

“…DNA double strand breaks (DSBs) are induced by external genotoxic agents (ionizing radiation or genotoxins) or by internal processes (recombination…”
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Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors by Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas, Liu, Xi, Bessone, Ivan Fernandez, di Magliano, Marina Pasca, Audebert, Stephane, Camoin, Luc, Estaras, Matias, Brenière, Manon, Modesti, Mauro, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan

“…We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven…”
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Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro by Vu, Duc-Duy, Bonucci, Alessio, Brenière, Manon, Cisneros-Aguirre, Metztli, Pelupessy, Philippe, Wang, Ziqing, Carlier, Ludovic, Bouvignies, Guillaume, Cortes, Patricia, Aggarwal, Aneel K., Blackledge, Martin, Gueroui, Zoher, Belle, Valérie, Stark, Jeremy M., Modesti, Mauro, Ferrage, Fabien

“…In mammalian cells, DNA double-strand breaks are predominantly repaired by non-homologous end joining (NHEJ). During repair, the Ku70–Ku80 heterodimer (Ku),…”
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Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors by Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas, Liu, Xi, Bessone, Ivan Fernandez, di Magliano, Marina Pasca, Audebert, Stephane, Camoin, Luc, Estaras, Matias, Brenière, Manon, Modesti, Mauro, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan

“…We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid-liquid phase separation (LLPS). NUPR1-driven…”
Get full text