Search Results - "Brenes, Alejandro J"

The Immunological Proteome Resource by Brenes, Alejandro J., Lamond, Angus I., Cantrell, Doreen A.

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Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome by Brenes, Alejandro J., Yoshikawa, Harunori, Bensaddek, Dalila, Mirauta, Bogdan, Seaton, Daniel, Hukelmann, Jens L., Jiang, Hao, Stegle, Oliver, Lamond, Angus I.

“…X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby transcription from one X chromosome is repressed. Analysis of…”
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Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures by Sollberger, Gabriel, Brenes, Alejandro J., Warner, Jordan, Arthur, J. Simon C., Howden, Andrew J. M.

“…Neutrophils are one of the first responders to infection and are a key component of the innate immune system through their ability to phagocytose and kill…”
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Deep proteomic analysis of microglia reveals fundamental biological differences between model systems by Lloyd, Amy F., Martinez-Muriana, Anna, Davis, Emma, Daniels, Michael J.D., Hou, Pengfei, Mancuso, Renzo, Brenes, Alejandro J., Sinclair, Linda V., Geric, Ivana, Snellinx, An, Craessaerts, Katleen, Theys, Tom, Fiers, Mark, De Strooper, Bart, Howden, Andrew J.M.

“…Using high-resolution quantitative mass spectrometry, we present comprehensive human and mouse microglia proteomic datasets consisting of over 11,000 proteins…”
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Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response by Ryan, Dylan G., Knatko, Elena V., Casey, Alva M., Hukelmann, Jens L., Dayalan Naidu, Sharadha, Brenes, Alejandro J., Ekkunagul, Thanapon, Baker, Christa, Higgins, Maureen, Tronci, Laura, Nikitopolou, Efterpi, Honda, Tadashi, Hartley, Richard C., O’Neill, Luke A.J., Frezza, Christian, Lamond, Angus I., Abramov, Andrey Y., Arthur, J. Simon C., Cantrell, Doreen A., Murphy, Michael P., Dinkova-Kostova, Albena T.

“…To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2…”
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Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes by Brenes, Alejandro J, Vandereyken, Maud, James, Olivia J, Watt, Harriet, Hukelmann, Jens, Spinelli, Laura, Dikovskaya, Dina, Lamond, Angus I, Swamy, Mahima

“…Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include…”
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DIA label-free proteomic analysis of murine bone-marrow-derived macrophages by Baker, Christa P., Phair, Iain R., Brenes, Alejandro J., Atrih, Abdelmadjid, Ryan, Dylan G., Bruderer, Roland, Dinkova-Kostova, Albena T., Lamont, Douglas J., Arthur, J. Simon C., Howden, Andrew J.M.

“…Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We…”
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Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS by Ly, Tony, Whigham, Arlene, Clarke, Rosemary, Brenes-Murillo, Alejandro J, Estes, Brett, Madhessian, Diana, Lundberg, Emma, Wadsworth, Patricia, Lamond, Angus I

“…The temporal regulation of protein abundance and post-translational modifications is a key feature of cell division. Recently, we analysed gene expression and…”
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Optimizing Spectronaut Search Parameters to Improve Data Quality with Minimal Proteome Coverage Reductions in DIA Analyses of Heterogeneous Samples by Baker, Christa P., Bruderer, Roland, Abbott, James, Arthur, J. Simon C., Brenes, Alejandro J.

“…Data-independent acquisition has seen breakthroughs that enable comprehensive proteome profiling using short gradients. As the proteome coverage continues to…”
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Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection by Long, Merete B, Howden, Andrew J M, Keir, Holly R, Rollings, Christina M, Giam, Yan Hui, Pembridge, Thomas, Delgado, Lilia, Abo-Leyah, Hani, Lloyd, Amy F, Sollberger, Gabriel, Hull, Rebecca, Gilmour, Amy, Hughes, Chloe, New, Benjamin J M, Cassidy, Diane, Shoemark, Amelia, Richardson, Hollian, Lamond, Angus I, Cantrell, Doreen A, Chalmers, James D, Brenes, Alejandro J

“…Neutrophils are important in the pathophysiology of coronavirus disease 2019 (COVID-19), but the molecular changes contributing to altered neutrophil…”
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Proteomic and functional comparison between human induced and embryonic stem cells by Brenes, Alejandro J, Griesser, Eva, Sinclair, Linda V, Davidson, Lindsay, Prescott, Alan R, Singh, Francois, Hogg, Elizabeth KJ, Espejo-Serrano, Carmen, Jiang, Hao, Yoshikawa, Harunori, Platani, Melpomeni, Swedlow, Jason R, Findlay, Greg M, Cantrell, Doreen A, Lamond, Angus I

“…Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and…”
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A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS by Reyes, Leila, A Sanchez-Garcia, Manuel, Morrison, Tyler, Howden, Andy J M, Watts, Emily R, Arienti, Simone, Sadiku, Pranvera, Coelho, Patricia, Mirchandani, Ananda S, Zhang, Ailiang, Hope, David, Clark, Sarah K, Singleton, Jo, Johnston, Shonna, Grecian, Robert, Poon, Azin, McNamara, Sarah, Harper, Isla, Fourman, Max Head, Brenes, Alejandro J, Pathak, Shalini, Lloyd, Amy, Blanco, Giovanny Rodriguez, von Kriegsheim, Alex, Ghesquiere, Bart, Vermaelen, Wesley, Cologna, Camila T, Dhaliwal, Kevin, Hirani, Nik, Dockrell, David H, Whyte, Moira K B, Griffith, David, Cantrell, Doreen A, Walmsley, Sarah R

“…Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with…”
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A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS by Reyes, Leila, A. Sanchez-Garcia, Manuel, Morrison, Tyler, Howden, Andy J. M., Watts, Emily R., Arienti, Simone, Sadiku, Pranvera, Coelho, Patricia, Mirchandani, Ananda S., Zhang, Ailiang, Hope, David, Clark, Sarah K., Singleton, Jo, Johnston, Shonna, Grecian, Robert, Poon, Azin, McNamara, Sarah, Harper, Isla, Fourman, Max Head, Brenes, Alejandro J., Pathak, Shalini, Lloyd, Amy, Blanco, Giovanny Rodriguez, von Kriegsheim, Alex, Ghesquiere, Bart, Vermaelen, Wesley, Cologna, Camila T., Dhaliwal, Kevin, Hirani, Nik, Dockrell, David H., Whyte, Moira K. B., Griffith, David, Cantrell, Doreen A., Walmsley, Sarah R.

“…Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is…”
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PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations by Fleming, Anna, Knatko, Elena V., Li, Xiang, Zoch, Ansgar, Heckhausen, Zoe, Stransky, Stephanie, Brenes, Alejandro J., Sidoli, Simone, Hajkova, Petra, O'Carroll, Dónal, Rasmussen, Kasper D.

“…The link between DNA methylation and neurodevelopmental disorders is well established. However, how DNA methylation is fine-tuned—ensuring precise gene…”
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Proteomic and functional comparison between human induced and embryonic stem cells by Brenes, Alejandro J, Griesser, Eva, Sinclair, Linda V, Davidson, Lindsay, Prescott, Alan R, Singh, Francois, Hogg, Elizabeth KJ, Espejo-Serrano, Carmen, Jiang, Hao, Yoshikawa, Harunori, Platani, Melpomeni, Swedlow, Jason R, Findlay, Greg M, Cantrell, Doreen A, Lamond, Angus I

“…Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and…”
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