Search Results - "Brendza, Robert"

Genetic ablation of Gpnmb does not alter synuclein-related pathology by Brendza, Robert, Lin, Han, Stark, Kimberly, Foreman, Oded, Tao, Janet, Pierce, Andrew, Ngu, Hai, Shen, Kimberle, Easton, Amy E., Bhangale, Tushar, Chang, Diana, Bingol, Baris, Friedman, Brad A.

“…The gene GPNMB is known to play roles in phagocytosis and tissue repair, and is upregulated in microglia in many mouse models of neurodegenerative disease as…”
Get full text

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement by Lee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded, Chan, Ruby, Ernst, James A., DiCara, Danielle, Hotzel, Isidro, Srinivasan, Karpagam, Hansen, David V., Atwal, Jasvinder, Lu, Yanmei, Bumbaca, Daniela, Pfeifer, Andrea, Watts, Ryan J., Muhs, Andreas, Scearce-Levie, Kimberly, Ayalon, Gai

“…The spread of tau pathology correlates with cognitive decline in Alzheimer’s disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although…”
Get full text

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease by Brendza, Robert, Gao, Xiaoying, Stark, Kimberly L., Lin, Han, Lee, Seung-Hye, Hu, Changyun, Cai, Hao, DiCara, Danielle, Hsiao, Yi-Chun, Ngu, Hai, Foreman, Oded, Baca, Miriam, Dohse, Monika, Fortin, Jean-Phillipe, Corpuz, Racquel, Seshasayee, Dhaya, Easton, Amy, Ayalon, Gai, Hötzel, Isidro, Chih, Ben

“…Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition…”
Get full text

Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition by Han, Byung Hee, Zhou, Meng-Liang, Abousaleh, Fadi, Brendza, Robert P, Dietrich, Hans H, Koenigsknecht-Talboo, Jessica, Cirrito, John R, Milner, Eric, Holtzman, David M, Zipfel, Gregory J

“…The contributing effect of cerebrovascular pathology in Alzheimer's disease (AD) has become increasingly appreciated. Recent evidence suggests that…”
Get full text

Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity by Weber, Martin, Min, Sang-Won, Truong, Tom, Hung, Jeffrey, Dale, Stephanie, Reichelt, Mike, Ubhayakar, Savita, Cain-Hom, Carol, Baca, Miriam, Jiang, Zhiyu, Li, Qingling, Brendza, Robert, Lin, Han, Kung, Chung, Forrest, William F., Quiason-Huynh, Cristine, Sandoval, Wendy, Chen, Buyun, Deng, Yuzhong, Easton, Amy, Foreman, Oded, Sene, Abdoulaye, Bingol, Baris

“…Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson’s Disease (PD). Since some GD and PD patients develop…”
Get full text

Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition by Song, Sheng-Kwei, Kim, Joong Hee, Lin, Shiow-Jiuan, Brendza, Robert P., Holtzman, David M.

“…Increasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease…”
Get full text

Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice by Brendza, Robert P, Bacskai, Brian J, Cirrito, John R, Simmons, Kelly A, Skoch, Jesse M, Klunk, William E, Mathis, Chester A, Bales, Kelly R, Paul, Steven M, Hyman, Bradley T, Holtzman, David M

“…Neuritic plaques are a defining feature of Alzheimer disease (AD) pathology. These structures are composed of extracellular accumulations of amyloid-beta…”
Get full text

A Function for Kinesin I in the Posterior Transport of Oskar mRNA and Staufen Protein by Brendza, Robert P., Serbus, Laura R., Duffy, Joseph B., Saxton, William M.

“…The asymmetric localization of messenger RNA (mRNA) and protein determinants plays an important role in the establishment of complex body plans. In Drosophila…”
Get full text

Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia by Holtzman, David M, Han, Byung Hee, DeMattos, Ronald B, Dugan, Laura L, Kim-Han, Jeong Sook, Brendza, Robert P, Fryer, John D, Kierson, Malca, Cirrito, John, Quick, Kevin, Harmony, Judith A. K, Aronow, Bruce J

“…Clusterin, also known as apolipoprotein J, is a ubiquitously expressed molecule thought to influence a variety of processes including cell death. In the brain,…”
Get full text

Posterior Localization of Dynein and Dorsal-Ventral Axis Formation Depend on Kinesin in Drosophila Oocytes by Brendza, Robert P., Serbus, Laura R., Saxton, William M., Duffy, Joseph B.

“…To establish the major body axes, late Drosophila oocytes localize determinants to discrete cortical positions: bicoid mRNA to the anterior cortex, oskar mRNA…”
Get full text

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice by DeMattos, Ronald B, Brendza, Robert P, Heuser, John E, Kierson, Malca, Cirrito, John R, Fryer, John, Sullivan, Patrick M, Fagan, Anne M, Han, Xianlin, Holtzman, David M

“…The ε4 allele of apolipoprotein E (apoE) is a genetic risk factor for Alzheimer's disease (AD). In order to gain a better understanding of the molecular…”
Get full text

Amyloid-β immunotherapies in mice and men by BRENDZA, Robert P, HOLTZMAN, David M

“…Given the compelling genetic and biochemical evidence that has implicated amyloid-beta (Abeta) in the pathogenesis of Alzheimer's disease, many studies have…”
Get full text

PDAPP; YFP double transgenic mice: A tool to study amyloid-β associated changes in axonal, dendritic, and synaptic structures by Brendza, Robert P., O'Brien, Cara, Simmons, Kelly, McKeel, Daniel W., Bales, Kelly R., Paul, Steven M., Olney, John W., Sanes, Joshua R., Holtzman, David M.

“…Neuritic plaques are one of the stereotypical hallmarks of Alzheimer's disease (AD) pathology. These structures are composed of extracellular accumulations of…”
Get full text

Use of YFP to study amyloid-β associated neurite alterations in live brain slices by Brendza, Robert P., Simmons, Kelly, Bales, Kelly R., Paul, Steven M., Goldberg, Mark P., Holtzman, David M.

“…Neuritic plaques are one of the defining neuropathological features of Alzheimer’s disease (AD). These structures are composed of a buildup of fibrils of the…”
Get full text

Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease by Ayalon, Gai, Lee, Seung-Hye, Adolfsson, Oskar, Foo-Atkins, Corinne, Atwal, Jasvinder K, Blendstrup, Mira, Booler, Helen, Bravo, Joseph, Brendza, Robert, Brunstein, Flavia, Chan, Ruby, Chandra, Priya, Couch, Jessica A, Datwani, Akash, Demeule, Barthélemy, DiCara, Danielle, Erickson, Rich, Ernst, James A, Foreman, Oded, He, Dongping, Hötzel, Isidro, Keeley, Michael, Kwok, Michael C M, Lafrance-Vanasse, Julien, Lin, Han, Lu, Yanmei, Luk, Wilman, Manser, Paul, Muhs, Andreas, Ngu, Hai, Pfeifer, Andrea, Pihlgren, Maria, Rao, Gautham K, Scearce-Levie, Kimberly, Schauer, Stephen P, Smith, William B, Solanoy, Hilda, Teng, Edmond, Wildsmith, Kristin R, Bumbaca Yadav, Daniela, Ying, Yong, Fuji, Reina N, Kerchner, Geoffrey A

“…Tau has become an attractive alternative target for passive immunotherapy efforts for Alzheimer's disease (AD). The anatomical distribution and extent of tau…”
Get more information

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS by Dominguez, Sara, Varfolomeev, Eugene, Brendza, Robert, Stark, Kim, Tea, Joy, Imperio, Jose, Ngu, Hai, Earr, Timothy, Foreman, Oded, Webster, Joshua D., Easton, Amy, Vucic, Domagoj, Bingol, Baris

“…RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in neurodegenerative disorders, including Amyotrophic Lateral Sclerosis…”
Get full text

Clonal tests of conventional kinesin function during cell proliferation and differentiation by Brendza, R P, Sheehan, K B, Turner, F R, Saxton, W M

“…Null mutations in the Drosophila Kinesin heavy chain gene (Khc), which are lethal during the second larval instar, have shown that conventional kinesin is…”
Get full text

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice by Brendza, Robert P., Bacskai, Brian J., Cirrito, John R., Simmons, Kelly A., Skoch, Jesse M., Klunk, William E., Mathis, Chester A., Bales, Kelly R., Paul, Steven M., Hyman, Bradley T., Holtzman, David M.

Get full text

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice by Brendza, Robert P., Bacskai, Brian J., Cirrito, John R., Simmons, Kelly A., Skoch, Jesse M., Klunk, William E., Mathis, Chester A., Bales, Kelly R., Paul, Steven M., Hyman, Bradley T., Holtzman, David M.

“…Neuritic plaques are a defining feature of Alzheimer disease (AD) pathology. These structures are composed of extracellular accumulations of amyloid-β peptide…”
Get full text

P2‐054: Tau antibodies lacking effector function minimize inflammatory responses while effectively blocking spread of tau pathology by Lee, Seung-Hye, Pichon, Claire, Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded, Chan, Ruby, Ernst, James, Dicara, Danielle, Hotzel, Isidro, Srinivasan, Karpagam, Hansen, David, Atwal, Jasvinder, Pfeifer, Andrea, Watts, Ryan, Muhs, Andreas, Scearce-Levie, Kimberly, Ayalon, Gai

Get full text