Search Results - "Brenda Phillips"

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction by Dunican, Eleanor M, Elicker, Brett M, Gierada, David S, Nagle, Scott K, Schiebler, Mark L, Newell, John D, Raymond, Wilfred W, Lachowicz-Scroggins, Marrah E, Di Maio, Selena, Hoffman, Eric A, Castro, Mario, Fain, Sean B, Jarjour, Nizar N, Israel, Elliot, Levy, Bruce D, Erzurum, Serpil C, Wenzel, Sally E, Meyers, Deborah A, Bleecker, Eugene R, Phillips, Brenda R, Mauger, David T, Gordon, Erin D, Woodruff, Prescott G, Peters, Michael C, Fahy, John V

“…The link between mucus plugs and airflow obstruction has not been established in chronic severe asthma, and the role of eosinophils and their products in mucus…”
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Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency by Peters, Michael C, Mauger, David, Ross, Kristie R, Phillips, Brenda, Gaston, Benjamin, Cardet, Juan Carlos, Israel, Elliot, Levy, Bruce D, Phipatanakul, Wanda, Jarjour, Nizar N, Castro, Mario, Wenzel, Sally E, Hastie, Annette, Moore, Wendy, Bleecker, Eugene, Fahy, John V, Denlinger, Loren C

“…Cross-sectional studies suggest an exacerbation-prone asthma (EPA) phenotype and the utility of blood eosinophils and plasma IL-6 as predictive biomarkers. To…”
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Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program by Hastie, Annette T, Mauger, David T, Denlinger, Loren C, Coverstone, Andrea, Castro, Mario, Erzurum, Serpil, Jarjour, Nizar, Levy, Bruce D, Meyers, Deborah A, Moore, Wendy C, Phillips, Brenda R, Wenzel, Sally E, Fahy, John V, Israel, Elliot, Bleecker, Eugene R

“…Some reports indicate longitudinal variability in sputum differential cell counts, whereas others describe stability. Highly variable sputum eosinophil…”
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Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma by Lachowicz-Scroggins, Marrah E, Dunican, Eleanor M, Charbit, Annabelle R, Raymond, Wilfred, Looney, Mark R, Peters, Michael C, Gordon, Erin D, Woodruff, Prescott G, Lefrançais, Emma, Phillips, Brenda R, Mauger, David T, Comhair, Suzy A, Erzurum, Serpil C, Johansson, Mats W, Jarjour, Nizar N, Coverstone, Andrea M, Castro, Mario, Hastie, Annette T, Bleecker, Eugene R, Fajt, Merritt L, Wenzel, Sally E, Israel, Elliot, Levy, Bruce D, Fahy, John V

“…Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and…”
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Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids by Peters, Michael C., Kerr, Sheena, Dunican, Eleanor M., Woodruff, Prescott G., Fajt, Merritt L., Levy, Bruce D., Israel, Elliot, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Wenzel, Sally E., Fahy, John V.

“…Airway type 2 inflammation is usually corticosteroid sensitive, but the role of type 2 inflammation as a mechanism of asthma in patients receiving high-dose…”
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Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations by Denlinger, Loren C, Phillips, Brenda R, Ramratnam, Sima, Ross, Kristie, Bhakta, Nirav R, Cardet, Juan Carlos, Castro, Mario, Peters, Stephen P, Phipatanakul, Wanda, Aujla, Shean, Bacharier, Leonard B, Bleecker, Eugene R, Comhair, Suzy A A, Coverstone, Andrea, DeBoer, Mark, Erzurum, Serpil C, Fain, Sean B, Fajt, Merritt, Fitzpatrick, Anne M, Gaffin, Jonathan, Gaston, Benjamin, Hastie, Annette T, Hawkins, Gregory A, Holguin, Fernando, Irani, Anne-Marie, Israel, Elliot, Levy, Bruce D, Ly, Ngoc, Meyers, Deborah A, Moore, Wendy C, Myers, Ross, Opina, Maria Theresa D, Peters, Michael C, Schiebler, Mark L, Sorkness, Ronald L, Teague, W Gerald, Wenzel, Sally E, Woodruff, Prescott G, Mauger, David T, Fahy, John V, Jarjour, Nizar N

“…Reducing asthma exacerbation frequency is an important criterion for approval of asthma therapies, but the clinical features of exacerbation-prone asthma (EPA)…”
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Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma by Wu, Wei, Bang, Seojin, Bleecker, Eugene R, Castro, Mario, Denlinger, Loren, Erzurum, Serpil C, Fahy, John V, Fitzpatrick, Anne M, Gaston, Benjamin M, Hastie, Annette T, Israel, Elliot, Jarjour, Nizar N, Levy, Bruce D, Mauger, David T, Meyers, Deborah A, Moore, Wendy C, Peters, Michael, Phillips, Brenda R, Phipatanakul, Wanda, Sorkness, Ronald L, Wenzel, Sally E

“…Corticosteroids (CSs) are the most effective asthma therapy, but responses are heterogeneous and systemic CSs lead to long-term side effects. Therefore, an…”
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Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time by Tang, Monica, Elicker, Brett M, Henry, Travis, Gierada, David S, Schiebler, Mark L, Huang, Brendan K, Peters, Michael C, Castro, Mario, Hoffman, Eric A, Fain, Sean B, Ash, Samuel Y, Choi, Jiwoong, Hall, Chase, Phillips, Brenda R, Mauger, David T, Denlinger, Loren C, Jarjour, Nizar N, Israel, Elliot, Phipatanakul, Wanda, Levy, Bruce D, Wenzel, Sally E, Bleecker, Eugene R, Woodruff, Prescott G, Fahy, John V, Dunican, Eleanor M

“…Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug…”
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Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3 by Gaffin, Jonathan M., Petty, Carter R., Sorkness, Ronald L., Denlinger, Loren C., Phillips, Brenda R., Ly, Ngoc P., Gaston, Benjamin, Ross, Kristie, Fitzpatrick, Anne, Bacharier, Leonard B., DeBoer, Mark D., Teague, W. Gerald, Wenzel, Sally E., Ramratnam, Sima, Israel, Elliot, Mauger, David T., Phipatanakul, Wanda

“…Children with asthma are at risk for low lung function extending into adulthood, but understanding of clinical predictors is incomplete. We sought to determine…”
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Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts by Peters, Michael C, MD, McGrath, Kelly Wong, MS, Hawkins, Gregory A, PhD, Hastie, Annette T, PhD, Levy, Bruce D, MD, Israel, Elliot, MD, Phillips, Brenda R, MS, Mauger, David T, PhD, Comhair, Suzy A, PhD, Erzurum, Serpil C, MD, Johansson, Mats W, PhD, Jarjour, Nizar N, MD, Coverstone, Andrea M, MD, Castro, Mario, MD, Holguin, Fernando, MD, Wenzel, Sally E, MD, Woodruff, Prescott G, MD, Bleecker, Eugene R, MD, Fahy, John V, Dr

“…Summary Background Severe asthma is a complex heterogeneous disease associated with older age and obesity. The presence of eosinophilic (type 2) inflammation…”
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The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma by Peters, Michael C, Schiebler, Mark L, Cardet, Juan Carlos, Johansson, Mats W, Sorkness, Ronald, DeBoer, Mark D, Bleecker, Eugene R, Meyers, Deborah A, Castro, Mario, Sumino, Kaharu, Erzurum, Serpil C, Tattersall, Matthew C, Zein, Joe G, Hastie, Annette T, Moore, Wendy, Levy, Bruce D, Israel, Elliot, Phillips, Brenda R, Mauger, David T, Wenzel, Sally E, Fajt, Merritt L, Koliwad, Suneil K, Denlinger, Loren C, Woodruff, Prescott G, Jarjour, Nizar N, Fahy, John V

“…The role of obesity-associated insulin resistance (IR) in airflow limitation in asthma is uncertain. Using data in the Severe Asthma Research Program 3…”
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Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program by Fitzpatrick, Anne M., Gillespie, Scott E., Mauger, David T., Phillips, Brenda R., Bleecker, Eugene R., Israel, Elliot, Meyers, Deborah A., Moore, Wendy C., Sorkness, Ronald L., Wenzel, Sally E., Bacharier, Leonard B., Castro, Mario, Denlinger, Loren C., Erzurum, Serpil C., Fahy, John V., Gaston, Benjamin M., Jarjour, Nizar N., Larkin, Allyson, Levy, Bruce D., Ly, Ngoc P., Ortega, Victor E., Peters, Stephen P., Phipatanakul, Wanda, Ramratnam, Sima, Teague, W. Gerald

“…Despite advances in asthma care, disparities persist. Black patients are disproportionally affected by asthma and also have poorer outcomes compared with white…”
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Severe asthma during childhood and adolescence: A longitudinal study by Ross, Kristie R., Gupta, Ritika, DeBoer, Mark D., Zein, Joe, Phillips, Brenda R., Mauger, David T., Li, Chun, Myers, Ross E., Phipatanakul, Wanda, Fitzpatrick, Anne M., Ly, Ngoc P., Bacharier, Leonard B., Jackson, Daniel J., Celedón, Juan C., Larkin, Allyson, Israel, Elliot, Levy, Bruce, Fahy, John V., Castro, Mario, Bleecker, Eugene R., Meyers, Deborah, Moore, Wendy C., Wenzel, Sally E., Jarjour, Nizar N., Erzurum, Serpil C., Teague, W.Gerald, Gaston, Benjamin

“…Morbidity and mortality associated with childhood asthma are driven disproportionately by children with severe asthma. However, it is not known from…”
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Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age by Teague, W. Gerald, Phillips, Brenda R., Fahy, John V., Wenzel, Sally E., Fitzpatrick, Anne M., Moore, Wendy C., Hastie, Annette T., Bleecker, Eugene R., Meyers, Deborah A., Peters, Stephen P., Castro, Mario, Coverstone, Andrea M., Bacharier, Leonard B., Ly, Ngoc P., Peters, Michael C., Denlinger, Loren C., Ramratnam, Sima, Sorkness, Ronald L., Gaston, Benjamin M., Erzurum, Serpil C., Comhair, Suzy A.A., Myers, Ross E., Zein, Joe, DeBoer, Mark D., Irani, Anne-Marie, Israel, Elliot, Levy, Bruce, Cardet, Juan Carlos, Phipatanakul, Wanda, Gaffin, Jonathan M., Holguin, Fernando, Fajt, Merritt L., Aujla, Shean J., Mauger, David T., Jarjour, Nizar N.

“…The effect of age on asthma severity is poorly understood. The objective of this study was to compare the baseline features of severe and nonsevere asthma in…”
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Forced expiratory flow between 25% and 75% of vital capacity and FEV1 /forced vital capacity ratio in relation to clinical and physiological parameters in asthmatic children with normal FEV1 values by Simon, Michael R., MD, Chinchilli, Vernon M., PhD, Phillips, Brenda R., MS, Sorkness, Christine A., PharmD, Lemanske, Robert F., MD, Szefler, Stanley J., MD, Taussig, Lynn, MD, Bacharier, Leonard B., MD, Morgan, Wayne, MD

“…Background The assumption that the assessment of forced expiratory flow between 25% and 75% of vital capacity (FEF25-75 ) does not provide additional…”
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Visualizing biological data in museums: Visitor learning with an interactive tree of life exhibit by Horn, Michael S., Phillips, Brenda C., Evans, Evelyn Margaret, Block, Florian, Diamond, Judy, Shen, Chia

“…In this study, we investigate museum visitor learning and engagement at an interactive visualization of an evolutionary tree of life consisting of over 70,000…”
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Estimation of the concordance correlation coefficient for repeated measures using SAS and R by Carrasco, Josep L, Phillips, Brenda R, Puig-Martinez, Josep, King, Tonya S, Chinchilli, Vernon M

“…Abstract The concordance correlation coefficient is one of the most common approaches used to assess agreement among different observers or instruments when…”
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Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing by Bacharier, Leonard B., MD, Phillips, Brenda R., MS, Zeiger, Robert S., MD, PhD, Szefler, Stanley J., MD, Martinez, Fernando D., MD, Lemanske, Robert F., MD, Sorkness, Christine A., PharmD, Bloomberg, Gordon R., MD, Morgan, Wayne J., MD, Paul, Ian M., MD, Guilbert, Theresa, MD, Krawiec, Marzena, MD, Covar, Ronina, MD, Larsen, Gary, MD, Mellon, Michael, MD, Moss, Mark H., MD, Chinchilli, Vernon M., PhD, Taussig, Lynn M., MD, Strunk, Robert C., MD

“…Background Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity. Objectives We sought to examine the effectiveness…”
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Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma by Tang, Monica, Charbit, Annabelle R., Johansson, Mats W., Jarjour, Nizar N., Denlinger, Loren C., Raymond, Wilfred W., Peters, Michael C., Dunican, Eleanor M., Castro, Mario, Sumino, Kaharu, Erzurum, Serpil C., Comhair, Suzy A., Moore, Wendy C., Levy, Bruce D., Israel, Elliot, Phipatanakul, Wanda, Phillips, Brenda R., Mauger, David T., Bleecker, Eugene R., Wenzel, Sally E., Fajt, Merritt L., Woodruff, Prescott G., Hastie, Annette T., Fahy, John V.

“…[Display omitted] The relative utility of eosinophil peroxidase (EPX) and blood and sputum eosinophil counts as disease biomarkers in asthma is uncertain. We…”
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Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program by Tattersall, Matthew C, Lee, Kristine E, Tsuchiya, Nanae, Osman, Fauzia, Korcarz, Claudia E, Hansen, Kristin M, Peters, Michael C, Fahy, John V, Longhurst, Colin A, Dunican, Eleanor, Wentzel, Sally E, Leader, Joseph K, Israel, Elliot, Levy, Bruce D, Castro, Mario, Erzurum, Serpil C, Lempel, Jason, Moore, Wendy C, Bleecker, Eugene R, Phillips, Brenda R, Mauger, David T, Hoffman, Eric A, Fain, Sean B, Reeder, Scott B, Sorkness, Ron L, Jarjour, Nizar N, Denlinger, Loren C, Schiebler, Mark L

“…Extrapulmonary manifestations of asthma, including fatty infiltration in tissues, may reflect systemic inflammation and influence lung function and disease…”
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