Search Results - "Brenchley, Paul E"

Antiphospholipase A2 Receptor Antibody Titer and Subclass in Idiopathic Membranous Nephropathy by HOFSTRA, Julia M, DEBIEC, Hanna, SHORT, Colin D, PELLE, Timotheé, KLETA, Robert, MATHIESON, Peter W, RONCO, Pierre, BRENCHLEY, Paul E, WETZELS, Jack F

“…The phospholipase A(2) receptor (PLA(2)R) is the major target antigen in idiopathic membranous nephropathy. The technique for measuring antibodies against…”
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Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy by Fresquet, Maryline, Jowitt, Thomas A, Gummadova, Jennet, Collins, Richard, O'Cualain, Ronan, McKenzie, Edward A, Lennon, Rachel, Brenchley, Paul E

“…Phospholipase A2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major…”
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Global Analysis Reveals the Complexity of the Human Glomerular Extracellular Matrix by LENNON, Rachel, BYRON, Adam, HUMPHRIES, Jonathan D, RANDLES, Michael J, CARISEY, Alex, MURPHY, Stephanie, KNIGHT, David, BRENCHLEY, Paul E, ZENT, Roy, HUMPHRIES, Martin J

“…The glomerulus contains unique cellular and extracellular matrix (ECM) components, which are required for intact barrier function. Studies of the cellular…”
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Pharmacology, efficacy and safety of oral phosphate binders by Hutchison, Alastair J, Smith, Craig P, Brenchley, Paul E. C

“…Most patients who are on dialysis require an oral phosphate binder; however, in the absence of robust data from clinical trials, guidelines on the ideal levels…”
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Phospholipase A2 Receptor (PLA2R1) Sequence Variants in Idiopathic Membranous Nephropathy by COENEN, Marieke J. H, HOFSTRA, Julia M, MATHIESON, Peter W, BRENCHLEY, Paul E, KLETA, Robert, WETZELS, Jack F. M, RONCO, Pierre, DEBIEC, Hanna, STANESCU, Horia C, MEDLAR, Alan J, STENGEL, Bénédicte, BOLAND-AUGE, Anne, GROOTHUISMINK, Johanne M, BOCKENHAUER, Detlef, POWIS, Steve H

“…The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic membranous nephropathy (iMN). Our recent genome-wide association…”
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The role of mouse strain differences in the susceptibility to fibrosis: a systematic review by Walkin, Louise, Herrick, Sarah E, Summers, Angela, Brenchley, Paul E, Hoff, Catherine M, Korstanje, Ron, Margetts, Peter J

“…In humans, a number of genetic factors have been linked to the development of fibrosis in a variety of different organs. Seeking a wider understanding of this…”
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PLA2R binds to the annexin A2-S100A10 complex in human podocytes by Fresquet, Maryline, Jowitt, Thomas A., McKenzie, Edward A., Ball, Matthew D., Randles, Michael J., Lennon, Rachel, Brenchley, Paul E.

“…Phospholipase A 2 receptor (PLA 2 R) is a member of the mannose receptor family found in podocytes in human kidney. PLA 2 R is the target of the autoimmune…”
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Membranous nephropathy: integrating basic science into improved clinical management by Cattran, Daniel C, Brenchley, Paul E

“…Idiopathic membranous nephropathy (INM) remains a common cause of the nephrotic syndrome in adults. The autoimmune nature of IMN was clearly delineated in 2009…”
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VEGF Polymorphisms Are Associated with Severity of Diabetic Retinopathy by Churchill, Amanda J, Carter, James G, Ramsden, Conor, Turner, Steven J, Yeung, Anna, Brenchley, Paul E. C, Ray, David W

“…To determine whether single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) gene are associated with severity of diabetic…”
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Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1) by Simmons, Suzanne C, McKenzie, Edward A, Harris, Lynda K, Aplin, John D, Brenchley, Paul E, Velasco-Garcia, Maria N, Missailidis, Sotiris

“…Heparanase is an enzyme involved in extracellular matrix remodelling and heparan sulphate proteoglycan catabolism. It is secreted by metastatic tumour cells,…”
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Interaction between Genetic Control of Vascular Endothelial Growth Factor Production and Retinoid Responsiveness in Psoriasis by Young, Helen S., Summers, Angela M., Read, Ian R., Fairhurst, David A., Plant, Darren J., Campalani, Emanuela, Smith, Catherine H., Barker, Jonathan N.W.N., Detmar, Michael J., Brenchley, Paul E.C., Griffiths, Christopher E.M.

“…Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, +405 and −460,…”
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Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy by Downie, Mallory L., Gupta, Sanjana, Tekman, Mehmet C., Cheshire, Chris, Arora, Steven, Licht, Christoph, Robinson, Lisa A., Munoz, Marina, Aris, Alvaro Madrid, Al Attrach, Ibrahim, Brenchley, Paul E., Gale, Daniel P., Stanescu, Horia, Bockenhauer, Detlef, Kleta, Robert

“…Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to…”
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Anti-heparanase aptamers as potential diagnostic and therapeutic agents for oral cancer by Simmons, Suzanne C, Jämsä, Hannaleena, Silva, Dilson, Cortez, Celia M, McKenzie, Edward A, Bitu, Carolina C, Salo, Sirpa, Nurmenniemi, Sini, Nyberg, Pia, Risteli, Juha, deAlmeida, Carlos E B, Brenchley, Paul E C, Salo, Tuula, Missailidis, Sotiris

“…Heparanase is an endoglycosidase enzyme present in activated leucocytes, mast cells, placental tissue, neutrophils and macrophages, and is involved in tumour…”
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Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy by Kanigicherla, Durga, Gummadova, Jennet, McKenzie, Edward A, Roberts, Stephen A, Harris, Shelley, Nikam, Milind, Poulton, Kay, McWilliam, Lorna, Short, Colin D, Venning, Michael, Brenchley, Paul E

“…Antibodies to the phospholipase A2 receptor 1 (PLA2R1) have been reported in 70% of cases of idiopathic membranous nephropathy (IMN). The genetic…”
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Association of anti-PLA₂R antibodies with outcomes after immunosuppressive therapy in idiopathic membranous nephropathy by Bech, Anneke P, Hofstra, Julia M, Brenchley, Paul E, Wetzels, Jack F M

“…The optimal timing and duration of immunosuppressive therapy for idiopathic membranous nephropathy (iMN) have been debated. This study aimed to evaluate…”
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Hypoxia increases heparanase-dependent tumor cell invasion, which can be inhibited by antiheparanase antibodies by XIAOTONG HE, BRENCHLEY, Paul E. C, JAYSON, Gordon C, HAMPSON, Lynne, DAVIES, John, HAMPSON, Ian N

“…The beta-endoglucuronidase heparanase plays an important role in tumor invasion, a process that is significantly enhanced by hypoxia. We have used a strategy…”
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Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch by Fresquet, Maryline, Lockhart-Cairns, Michael P, Rhoden, Samuel J, Jowitt, Thomas A, Briggs, David C, Baldock, Clair, Brenchley, Paul E, Lennon, Rachel

“…Membranous nephropathy is an autoimmune kidney disease caused by autoantibodies targeting antigens present on glomerular podocytes, instigating a cascade…”
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VEGF –460 genotype plays an important role in progression to chronic kidney disease stage 5 by Summers, Angela M., Coupes, Beatrice M., Brennan, Mary Frances, Ralph, Shirley A., Short, Colin D., Brenchley, Paul E. C.

“…Background. Changes in renal vasculature, with vascular and interstitial fibrosis, are hallmarks of progression to chronic kidney disease (CKD) stage 5…”
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Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma by Ralph, Shirley, Brenchley, Paul E. C., Summers, Angela, Rosa, Daniela D., Swindell, Ric, Jayson, Gordon C.

“…Heparanase (HSPE‐1) and vascular endothelial growth factor (VEGF), proangiogenic growth factors, play important roles in the metastatic biology of ovarian…”
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Anti-PLA2R Antibody Levels and Clinical Risk Factors for Treatment Nonresponse in Membranous Nephropathy by Barbour, Sean J, Fervenza, Fernando C, Induruwage, Dilshani, Brenchley, Paul E, Rovin, Brad, Hladunewich, Michelle A, Reich, Heather N, Lafayette, Richard, Aslam, Nabeel, Appel, Gerald B, Zand, Ladan, Kiryluk, Krzysztof, Liu, Lili, Cattran, Daniel C

“…The 2021 Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend following anti-phospholipase A2 receptor (PLA2R) antibody levels as a marker of…”
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