Search Results - "Brené, Stefan"

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development by Ross, Jaime M., Stewart, James B., Hagström, Erik, Brené, Stefan, Mourier, Arnaud, Coppotelli, Giuseppe, Freyer, Christoph, Lagouge, Marie, Hoffer, Barry J., Olson, Lars, Larsson, Nils-Göran

“…Mutations in mitochondrial DNA (mtDNA) accumulate at a higher rate than mutations in nuclear DNA, and although somatic mtDNA mutations are known to be involved…”
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Default mode network, motor network, dorsal and ventral basal ganglia networks in the rat brain: comparison to human networks using resting state-fMRI by Sierakowiak, Adam, Monnot, Cyril, Aski, Sahar Nikkhou, Uppman, Martin, Li, Tie-Qiang, Damberg, Peter, Brené, Stefan

“…Rodent models are developed to enhance understanding of the underlying biology of different brain disorders. However, before interpreting findings from animal…”
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Running Opposes the Effects of Social Isolation on Synaptic Plasticity and Transmission in a Rat Model of Depression by Gómez-Galán, Marta, Femenía, Teresa, Åberg, Elin, Graae, Lisette, Van Eeckhaut, Ann, Smolders, Ilse, Brené, Stefan, Lindskog, Maria

“…Stress, such as social isolation, is a well-known risk factor for depression, most probably in combination with predisposing genetic factors. Physical exercise…”
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Orchestrated regulation of Nogo receptors, LOTUS, AMPA receptors and BDNF in an ECT model suggests opening and closure of a window of synaptic plasticity by Nordgren, Max, Karlsson, Tobias, Svensson, Maria, Koczy, Josefin, Josephson, Anna, Olson, Lars, Tingström, Anders, Brené, Stefan

“…Electroconvulsive therapy (ECT) is an efficient and relatively fast acting treatment for depression. However, one severe side effect of the treatment is…”
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Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson’s disease by Lai, Jing-Huei, Chen, Kai-Yun, Wu, John Chung-Che, Olson, Lars, Brené, Stefan, Huang, Chi-Zong, Chen, Yen-Hua, Kang, Shuo-Jhen, Ma, Kuo-Hsing, Hoffer, Barry J., Hsieh, Tsung-Hsun, Chiang, Yung-Hsiao

“…•Exercise increased levels of DA and the DA membrane transporter, measured by HPLC and PET, respectively.•Exercise increases oxygen consumption and, by…”
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NgR1: A Tunable Sensor Regulating Memory Formation, Synaptic, and Dendritic Plasticity by Karlsson, Tobias E, Smedfors, Gabriella, Brodin, Alvin T S, Åberg, Elin, Mattsson, Anna, Högbeck, Isabelle, Wellfelt, Katrin, Josephson, Anna, Brené, Stefan, Olson, Lars

“…Nogo receptor 1 (NgR1) is expressed in forebrain neurons and mediates nerve growth inhibition in response to Nogo and other ligands. Neuronal activity…”
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Neurotrophic Factors and Receptors in the Immature and Adult Spinal Cord after Mechanical Injury or Kainic Acid by Widenfalk, Johan, Lundstromer, Karin, Jubran, Marie, Brene, Stefan, Olson, Lars

“…Delivery of neurotrophic factors to the injured spinal cord has been shown to stimulate neuronal survival and regeneration. This indicates that a lack of…”
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Running has Differential Effects on NPY, Opiates, and Cell Proliferation in an Animal Model of Depression and Controls by BJORNEBEKK, Astrid, MATHE, Aleksander A, BRENE, Stefan

“…Physical activity has documented beneficial effect in treatment of depression. Recently, we found an antidepressant-like effect of running in an animal model…”
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Early modulation by the dopamine D4 receptor of morphine-induced changes in the opioid peptide systems in the rat caudate putamen by Gago, Belén, Fuxe, Kjell, Brené, Stefan, Díaz-Cabiale, Zaida, Reina-Sánchez, María Dolores, Suárez-Boomgaard, Diana, Roales-Buján, Ruth, Valderrama-Carvajal, Alejandra, de la Calle, Adelaida, Rivera, Alicia

“…The peptides dynorphin and enkephalin modulate many physiological processes, such as motor activity and the control of mood and motivation. Their expression in…”
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Effect of acute and continuous morphine treatment on transcription factor expression in subregions of the rat caudate putamen. Marked modulation by D4 receptor activation by Gago, Belén, Suárez-Boomgaard, Diana, Fuxe, Kjell, Brené, Stefan, Reina-Sánchez, María Dolores, Rodríguez-Pérez, Luis M, Agnati, Luigi F, de la Calle, Adelaida, Rivera, Alicia

“…Abstract Acute administration of the dopamine D4 receptor (D4 R) agonist PD168,077 induces a down-regulation of the μ opioid receptor (MOR) in the striosomal…”
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The selective κ-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat by Lindholm, Sara, Werme, Martin, Brené, Stefan, Franck, Johan

“…Non-selective opioid receptor antagonists are increasingly used in the treatment of alcohol dependence. The clinical effects are significant but the effect…”
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Lrrk2 and α-synuclein are co-regulated in rodent striatum by Westerlund, Marie, Ran, Caroline, Borgkvist, Anders, Sterky, Fredrik H., Lindqvist, Eva, Lundströmer, Karin, Pernold, Karin, Brené, Stefan, Kallunki, Pekka, Fisone, Gilberto, Olson, Lars, Galter, Dagmar

“…LRRK2, α-synuclein, UCH-L1 and DJ-1 are implicated in the etiology of Parkinson's disease. We show for the first time that increase in striatal α-synuclein…”
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Running increases ethanol preference by Werme, Martin, Lindholm, Sara, Thorén, Peter, Franck, Johan, Brené, Stefan

“…Wheel running performed by rats is reinforcing, rewarding and possibly addictive. In this study we analyzed if wheel running could affect ethanol preference…”
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High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio by Ross, Jaime M., Öberg, Johanna, Brené, Stefan, Coppotelli, Giuseppe, Terzioglu, Mügen, Pernold, Karin, Goiny, Michel, Sitnikov, Rouslan, Kehr, Jan, Trifunovic, Aleksandra, Larsson, Nils-Göran, Hoffer, Barry J., Olson, Lars, Bloom, Floyd

“…At present, there are few means to track symptomatic stages of CNS aging. Thus, although metabolic changes are implicated in mtDNA mutation-driven aging, the…”
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Neuronal activity-induced regulation of Lingo-1 by Trifunovski, Alexandra, Josephson, Anna, Ringman, Andreas, Brené, Stefan, Spenger, Christian, Olson, Lars

“…Axonal regeneration after injury can be limited in the adult CNS by the presence of inhibitory proteins such as Nogo. Nogo binds to a receptor complex that…”
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Neurotrophin levels and behaviour in BALB/c mice: Impact of intermittent exposure to individual housing and wheel running by Zhu, Shun-Wei, Pham, Therese M., Åberg, Elin, Brené, Stefan, Winblad, Bengt, Mohammed, Abdul H., Baumans, Vera

“…This study assessed the effects of intermittent individual housing on behaviour and brain neurotrophins, and whether physical exercise could influence…”
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inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression by Maes, Michael, Yirmyia, Raz, Noraberg, Jens, Brene, Stefan, Hibbeln, Joe, Perini, Giulia, Kubera, Marta, Bob, Petr, Lerer, Bernard, Maj, Mario

“…Despite extensive research, the current theories on serotonergic dysfunctions and cortisol hypersecretion do not provide sufficient explanations for the nature…”
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Differential patterns of induction of NGFI-B, Nor1 and c-fos mRNAs in striatal subregions by haloperidol and clozapine by Werme, Martin, Ringholm, Aneta, Olson, Lars, Brené, Stefan

“…Disturbances of retinoid activated transcription mechanisms have recently been implicated as risk factors for schizophrenia. In this study we have compared the…”
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Cortical sensory map rearrangement after spinal cord injury: fMRI responses linked to Nogo signalling by Endo, Toshiki, Spenger, Christian, Tominaga, Teiji, Brené, Stefan, Olson, Lars

“…Cortical sensory maps can reorganize in the adult brain in an experience-dependent manner. We monitored somatosensory cortical reorganization after sensory…”
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The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression by Bjornebekk, A, Mathe, AA, Brene, S

“…One hypothesis of depression is that it is caused by reduced neuronal plasticity including hippocampal neurogenesis. In this study, we compared the effects of…”
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