Search Results - "Bren, G D"

Flying in the Face of Resistance: Antiviral-independent Benefit of HIV Protease Inhibitors on T-cell Survival by Vlahakis, S R, Bren, G D, Algeciras‐Schimnich, A, Trushin, S A, Schnepple, D J, Badley, A D

“…Human immunodeficiency virus (HIV) infection results in excessive apoptosis of infected and uninfected cells, mediated by host and viral factors present in…”
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Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation by Mcelhinny, Julie A., Trushin, Sergey A., Bren, Gary D., Chester, Nicholas, Paya, Carlos V.

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Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways by Steffan, NM, Bren, GD, Frantz, B, Tocci, MJ, O'Neill, EA, Paya, CV

“…The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines…”
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NF-κB cis-Acting Motifs of the Human Immunodeficiency Virus (HIV) Long Terminal Repeat Regulate HIV Transcription in Human Macrophages by Asin, Susana, Bren, Gary D., Carmona, Eva M., Solan, Nancie J., Paya, Carlos V.

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Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes by Folgueira, L, McElhinny, J A, Bren, G D, MacMorran, W S, Diaz-Meco, M T, Moscat, J, Paya, C V

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Expression of p53 and 17p allelic loss in colorectal carcinoma by CUNNINGHAM, J, LUST, J. A, SCHAID, D. J, BREN, G. D, CARPENTER, H. A, RIZZA, E, KOVACH, J. S, THIBODEAU, S. N

“…Mutations in the p53 gene are the most common genetic changes in cancer thus far. Many p53 mutations result in a protein product having a prolonged half-life…”
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Signal transduction pathways triggered by the FcϵRIIb receptor (CD23) in human monocytes lead to nuclear factor-κB activation by Ten, Rosa M., McKinstry, Melissa J., Bren, Gary D., Paya, Carlos V.

“…Background: Alveolar macrophages play a key role in the initiation of the inflammatory reaction of allergic asthma. Alveolar macrophages and peripheral blood…”
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RelB Cellular Regulation and Transcriptional Activity Are Regulated by p100 by Solan, Nancie J, Miyoshi, Hiroko, Carmona, Eva M, Bren, Gary D, Paya, Carlos V

“…RelB mediates the constitutive nuclear pool of NF-κB transcriptional activity in myeloid and lymphoid cells, which is believed to be secondary to its weak…”
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Transcription of the RelB gene is regulated by NF-κB by BREN, Gary D, SOLAN, Nancie J, MIYOSHI, Hiroko, PENNINGTON, Kevin N, POBST, Lori J, PAYA, Carlos V

“…RelA and RelB are two members of the NF-κB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by…”
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Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus by McElhinny, J A, MacMorran, W S, Bren, G D, Ten, R M, Israel, A, Paya, C V

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Human Immunodeficiency Virus–Induced Apoptosis of Human Hepatocytes via CXCR4 by Vlahakis, Stacey R., Villasis-Keever, Angelina, Gomez, Timothy S., Bren, Gary D., Paya, Carlos V.

“…Human immunodeficiency virus (HIV) infection is commonly associated with liver dysfunction. The X4 HIV glycoprotein 120 envelope (env) induces apoptosis in T…”
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The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia by Tefferi, A, Bren, G D, Wagner, K V, Schaid, D J, Ash, R C, Thibodeau, S N

“…Chronic granulocytic leukemia (CGL) is associated with a reciprocal translocation between chromosomes 9 and 22. The breakpoint sites on chromosome 22 are…”
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Interactions of Radioprotectors and Oxygen in Cultured Mammalian Cells: II. Effects of Dithiothreitol on Radiation-Induced DNA Damage and Comparison with Cell Survival by Held, Kathryn D., Bren, Gary D., Melder, Deborah C.

“…The effects of the sulfhydryl-containing compound dithiothreitol (DTT) on radiation-induced DNA damage have been studied using two different assays: DNA…”
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DNA Damage Measured Using the Alkaline Elution Assay Depends on Time between Subculturing of Cells and Irradiation by Held, Kathryn D., Bren, Gary D.

“…In experiments utilizing the alkaline filter elution assay for radiation-induced DNA damage we observed an unexpected dependence of hypoxic dose-response…”
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Serine 32 and serine 36 of IκBα are directly phosphorylated by protein kinase CKII in Vitro by Taylor, Julie A, Bren, Gary D, Pennington, Kevin N, Trushin, Sergey A, Asin, Susana, Paya, Carlos V

“…IκBα is an inherently unstable protein which binds to and retains the ubiquitous transcription factor NFκB in the cytoplasm of resting cells. A continuous low…”
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The Ras-Raf pathway is activated in human immunodeficiency virus infected monocytes and participates in the activation of NF- Kappa B by Folgueira, L, Algeciras, A, MacMorran, W S, Bren, G D, Paya, C V

“…Persistent human immunodeficiency virus (HIV) infection of human monocytes and macrophages increases I Kappa B alpha degradation, resulting in the activation…”
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The Ras-Raf pathway is activated in human immunodeficiency virus-infected monocytes and particpates in the activation of NF-kappa B by Folgueira, L, Algeciras, A, MacMorran, W S, Bren, G D, Paya, C V

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HIV elite control is associated with reduced TRAILshort expression by Paim, Ana C, Cummins, Nathan W, Natesampillai, Sekar, Garcia-Rivera, Enrique, Kogan, Nicole, Neogi, Ujjwal, Sönnerborg, Anders, Sperk, Maike, Bren, Gary D, Deeks, Steve, Polley, Eric, Badley, Andrew D

“…OBJECTIVE:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) dependent apoptosis has been implicated in CD4 T-cell death and immunologic control…”
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Casp8p41 expression in primary T cells induces a proinflammatory response by TAYLOR, Julie A, CUMMINS, Nathan W, BREN, Gary D, RIZZA, Stacey A, KOLBERT, Christopher P, BEHRENS, Marshall D, KNUTSON, Keith L, KAHL, Jane C, ASMANN, Yan W, BADLEY, Andrew D

“…HIV infection of CD4 T cells can lead to HIV protease-mediated cleavage of procaspase 8 generating a novel, HIV-specific peptide called Casp8p41. Casp8p41 has…”
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NELFINAVIR/RITONAVIR REDUCE ACINAR INJURY IN MOUSE CAERULEIN PANCREATITIS by Singh, V P, Bren, G D, Vlahakis, S R, Chari, S T, Vege, S S, Badley, A D

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