Search Results - "Bremberg, Ulf"

Rapid Microwave-Induced Palladium-Catalyzed Asymmetric Allylic Alkylation by Bremberg, Ulf, Larhed, Mats, Moberg, Christina, Hallberg, Anders

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Palladium-catalyzed allylic alkylation using pyridino-oxazolines and quinolino-oxazolines as ligands—influence of steric factors by Bremberg, Ulf, Rahm, Fredrik, Moberg, Christina

“…Four new chiral pyridino- and quinolino-oxazolines were subjected to the palladium-catalyzed alkylation of 1,3-diphenyl-2-propenyl acetate. The…”
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Chiral ditopic receptors. Application to palladium-catalyzed allylic alkylation by Bourguignon, Jean, Bremberg, Ulf, Dupas, Georges, Hallman, Kristina, Hagberg, Lars, Hortala, Laurent, Levacher, Vincent, Lutsenko, Serghey, Macedo, Emmanuel, Moberg, Christina, Quéguiner, Guy, Rahm, Fredrik

“…Chiral pyridinooxazoline, quinolinooxazoline, bis(oxazolino)pyridine (pybox), and bisoxazoline (box) derivatives containing crown ether residues were prepared…”
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Synthesis of enantiopure angiotensin II type 2 receptor [AT2R] antagonist EMA401 by Wakchaure, Prasad B., Bremberg, Ulf, Wannberg, Johan, Larhed, Mats

“…We report a facile synthesis of the angiotensin II type 2 receptor antagonist EMA401, which recently passed phase II clinical trials, in high overall yield…”
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A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes by Wannberg, Johan, Isaksson, Rebecka, Bremberg, Ulf, Backlund, Maria, Sävmarker, Jonas, Hallberg, Mathias, Larhed, Mats

“…[Display omitted] •Potent AT2R ligands were synthesized by a fast transesterification reaction.•AT2R ligands equipotent to C38 with improved metabolic…”
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Development of a Synthesis of Kinase Inhibitor AKN028 by Bremberg, Ulf, Eriksson-Bajtner, Johan, Lehmann, Fredrik, Oltner, Viveca, Sölver, Ellen, Wennerberg, Johan

“…The novel tyrosine kinase inhibitor AKN028 has demonstrated promising results in preclinical trials. An expedient protocol for the synthesis of the compound at…”
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Abstract 3843: LSD1 modulation by allosteric ligands by Emond, Wei B., Geitmann, Matthis, Jarvius, Malin, Koehler, Konrad, Källblad, Per, Niklasson, Mia, Parrow, Vendela, Sawant, Rajiv, Sjöberg, Maria, Winquist, Johan, Segerman, Anna, Bremberg, Ulf

“…Abstract LSD1 has emerged as a potential therapeutic target for a number of cancer types (e.g. AML, SCLC, colorectal, breast, liver, prostate, glioblastoma,…”
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Abstract LB029: Degraders of TEAD transcription factors based on interface 3 binders by Sawant, Rajiv, Geitmann, Matthis, Gossas, Thomas, Emond, Wei B., Bremberg, Ulf, Koehler, Konrad, Ceribelli, Michele, Thomas, Craig J., Brandt, Peter

“…Abstract TEAD transcription factors have emerged as clinically validated targets for Hippo-altered cancers, e.g. mesothelioma driven by NF2…”
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Iron chelators target both proliferating and quiescent cancer cells by Fryknäs, Mårten, Zhang, Xiaonan, Bremberg, Ulf, Senkowski, Wojciech, Olofsson, Maria Hägg, Brandt, Peter, Persson, Ingmar, D’Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Schughart, Leoni Kunz, Linder, Stig, Larsson, Rolf

“…Poorly vascularized areas of solid tumors contain quiescent cell populations that are resistant to cell cycle-active cancer drugs. The compound VLX600 was…”
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Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1 by Mould, Daniel P., Bremberg, Ulf, Jordan, Allan M., Geitmann, Matthis, Maiques-Diaz, Alba, McGonagle, Alison E., Small, Helen F., Somervaille, Tim C.P., Ogilvie, Donald

“…[Display omitted] A series of reversible inhibitors of lysine specific demethylase 1 (LSD1) with a 5-hydroxypyrazole scaffold have been developed from compound…”
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Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1 by Mould, Daniel P., Bremberg, Ulf, Jordan, Allan M., Geitmann, Matthis, McGonagle, Alison E., Somervaille, Tim C.P., Spencer, Gary J., Ogilvie, Donald J.

“…[Display omitted] As part of our ongoing efforts to develop reversible inhibitors of LSD1, we identified a series of 4-(pyrrolidin-3-yl)benzonitrile…”
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Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity by Karlsson, Henning, Fryknäs, Mårten, Strese, Sara, Gullbo, Joachim, Westman, Gunnar, Bremberg, Ulf, Sjöblom, Tobias, Pandzic, Tatjana, Larsson, Rolf, Nygren, Peter

“…The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We…”
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Abstract 705: Potentiation of immunotherapy by LSD1 modulation by Emond, Wei B., Sawant, Rajiv, Geitmann, Matthis, Winquist, Johan, Brandt, Peter, Bremberg, Ulf, Källblad, Per, Parrow, Vendela, Andersson, Claes, Blom, Kristin, Najafi, Nasrin, Bergström, Tobias, Swartling, Fredrik J., Hellström, Mats, Koehler, Konrad F.

“…Abstract LSD1 has emerged as a potential therapeutic target to increase the effectiveness of cancer immunotherapy. We have developed a series of novel small…”
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Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1 by Mould, Daniel P, Alli, Cristina, Bremberg, Ulf, Cartic, Sharon, Jordan, Allan M, Geitmann, Matthis, Maiques-Diaz, Alba, McGonagle, Alison E, Somervaille, Tim C. P, Spencer, Gary J, Turlais, Fabrice, Ogilvie, Donald

“…Inhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the differentiation of leukemia stem cells in acute myeloid leukemia (AML)…”
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Fast, Convenient, and Efficient Molybdenum-Catalyzed Asymmetric Allylic Alkylation under Noninert Conditions: An Example of Microwave-Promoted Fast Chemistry by Kaiser, Nils-Fredrik K., Bremberg, Ulf, Larhed, Mats, Moberg, Christina, Hallberg, Anders

“…Microwave heating allows regio‐ and enantioselective allylic alkylation to be carried out in air in a few minutes in a convenient one‐pot procedure [Eq. (1)]…”
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Highly Stereo- and Regioselective Allylations Catalyzed by Mo−Pyridylamide Complexes:  Electronic and Steric Effects of the Ligand by Belda, Oscar, Kaiser, Nils-Fredrik, Bremberg, Ulf, Larhed, Mats, Hallberg, Anders, Moberg, Christina

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(Hydroxyalkyl)pyridinooxazolines in Palladium-Catalyzed Allylic Substitutions. Conformational Preferences of the Ligand by Svensson, Mats, Bremberg, Ulf, Hallman, Kristina, Csöregh, Ingeborg, Moberg, Christina

“…2-(3‘,4‘-Dihydro-2‘-oxazolyl)-6-(hydroxymethyl)pyridines have been shown by X-ray crystallographic analysis and DFT calculations to exhibit two conformational…”
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Microwave-mediated palladium-catalyzed asymmetric allylic alkylation; an example of highly selective fast chemistry by Kaiser, Nils-Fredrik K, Bremberg, Ulf, Larhed, Mats, Moberg, Christina, Hallberg, Anders

“…Highly enantioselective palladium-catalyzed microwave-mediated fast chemistry has been performed on dimethyl malonate alkylation of (…”
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Selectivity and reactivity in asymmetric allylic alkylation by Moberg, C., Bremberg, Ulf, Hallman, Kristina, Svensson, M., Norrby, P.-O., Hallberg, Anders, Larhed, Mats, Csöregh, Ingeborg

“…2-(1-Hydroxyalkyl)-6-oxazolyl-and 2-(1-alkoxyalkyl)-6-oxazolylpyridines serve as versatile ligands in the palladium-catalyzed allylic substitution of…”
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Fast, Convenient, and Efficient Molybdenum-Catalyzed Asymmetric Allylic Alkylation under Noninert Conditions: An Example of Microwave-Promoted Fast Chemistry by Kaiser, Nils-Fredrik K., Bremberg, Ulf, Larhed, Mats, Moberg, Christina, Hallberg, Anders

“…Mikrowellenerhitzen ermöglicht es, in einer gewöhnlichen Eintopfsynthese regio‐ und enantioselektive allylische Alkylierungen an der Luft innerhalb weniger…”
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