Search Results - "Brekken, Rolf A"

Pancreatic cancer stroma: an update on therapeutic targeting strategies by Hosein, Abdel N., Brekken, Rolf A., Maitra, Anirban

“…Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in the Western world with limited therapeutic options and dismal…”
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Exploration of Nanoparticle-Mediated Photothermal Effect of TMB‑H2O2 Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay by Fu, Guanglei, Sanjay, Sharma T, Zhou, Wan, Brekken, Rolf A, Kirken, Robert A, Li, XiuJun

“…The exploration of new physical and chemical properties of materials and their innovative application in different fields are of great importance to advance…”
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The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer by Huang, Huocong, Brekken, Rolf A

“…The stroma of pancreatic ductal adenocarcinoma (PDA) forms a major barrier to therapy and immune surveillance. Elahi-Gedwillo and colleagues demonstrate that…”
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Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies by Sharma, Raghava, Huang, Xianming, Brekken, Rolf A, Schroit, Alan J

“…Background: There has been increasing interest in the detection of tumour exosomes in blood for cancer diagnostics. Most studies have focussed on miRNA and…”
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Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer by Ham, In-Hye, Oh, Hye Jeong, Jin, Hyejin, Bae, Cheong A, Jeon, Sang-Min, Choi, Kyeong Sook, Son, Sang-Yong, Han, Sang-Uk, Brekken, Rolf A, Lee, Dakeun, Hur, Hoon

“…Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role in chemo-resistance, specific targets to inhibit the interaction…”
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27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth by Wu, Qian, Ishikawa, Tomonori, Sirianni, Rosa, Tang, Hao, McDonald, Jeffrey G., Yuhanna, Ivan S., Thompson, Bonne, Girard, Luc, Mineo, Chieko, Brekken, Rolf A., Umetani, Michihisa, Euhus, David M., Xie, Yang, Shaul, Philip W.

“…To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite…”
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Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice by Yang, Liu, Kwon, Junghee, Popov, Yury, Gajdos, Gabriella B, Ordog, Tamas, Brekken, Rolf A, Mukhopadhyay, Debabrata, Schuppan, Detlef, Bi, Yan, Simonetto, Douglas, Shah, Vijay H

“…Background & Aims Vascular endothelial growth factor (VEGF)−induced angiogenesis is implicated in fibrogenesis and portal hypertension. However, the function…”
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Dichotomous effects of VEGF-A on adipose tissue dysfunction by Sun, Kai, Asterholm, Ingrid Wernstedt, Kusminski, Christine M, Bueno, Ana Carolina, Wang, Zhao V, Pollard, Jeffrey W, Brekken, Rolf A, Scherer, Philipp E

“…Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis, inflammation, and ultimately insulin resistance. We hypothesized…”
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Getting a grip on adhesion: Cadherin switching and collagen signaling by Huang, Huocong, Wright, Steven, Zhang, Junqiu, Brekken, Rolf A.

“…Epithelial-mesenchymal transition (EMT) is a developmental biological process that is hijacked during tumor progression. Cadherin switching, which disrupts…”
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Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution by Hosein, Abdel Nasser, Huang, Huocong, Wang, Zhaoning, Parmar, Kamalpreet, Du, Wenting, Huang, Jonathan, Maitra, Anirban, Olson, Eric, Verma, Udit, Brekken, Rolf A

“…Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death with limited therapeutic options available. This highlights the need for…”
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Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer by Ludwig, Kathleen F, Du, Wenting, Sorrelle, Noah B, Wnuk-Lipinska, Katarzyna, Topalovski, Mary, Toombs, Jason E, Cruz, Victoria H, Yabuuchi, Shinichi, Rajeshkumar, N V, Maitra, Anirban, Lorens, James B, Brekken, Rolf A

“…Activation of the receptor tyrosine kinase Axl is associated with poor outcomes in pancreatic cancer (PDAC), where it coordinately mediates immune evasion and…”
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Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium by Dellinger, Michael T, Brekken, Rolf A

“…There is growing evidence that vascular endothelial growth factor-A (VEGF-A), a ligand of the receptor tyrosine kinases VEGFR1 and VEGFR2, promotes…”
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TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy by Dayoub, Adam S, Brekken, Rolf A

“…Immunotherapy for cancer is making impressive strides at improving survival of a subset of cancer patients. To increase the breadth of patients that benefit…”
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A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth by Wang, Lei, Chang, Jianjun, Varghese, Diana, Dellinger, Michael, Kumar, Subodh, Best, Anne M., Ruiz, Julio, Bruick, Richard, Peña-Llopis, Samuel, Xu, Junjie, Babinski, David J., Frantz, Doug E., Brekken, Rolf A., Quinn, Amy M., Simeonov, Anton, Easmon, Johnny, Martinez, Elisabeth D.

“…The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signalling…”
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Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis by Kirane, Amanda, Ludwig, Kathleen F, Sorrelle, Noah, Haaland, Gry, Sandal, Tone, Ranaweera, Renate, Toombs, Jason E, Wang, Miao, Dineen, Sean P, Micklem, David, Dellinger, Michael T, Lorens, James B, Brekken, Rolf A

“…Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used…”
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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan by Wang, Chensu, Niederstrasser, Hanspeter, Douglas, Peter M., Lin, Rueyling, Jaramillo, Juan, Li, Yang, Oswald, Nathaniel W., Zhou, Anwu, McMillan, Elizabeth A., Mendiratta, Saurabh, Wang, Zhaohui, Zhao, Tian, Lin, Zhiqaing, Luo, Min, Huang, Gang, Brekken, Rolf A., Posner, Bruce A., MacMillan, John B., Gao, Jinming, White, Michael A.

“…Drugs that mirror the cellular effects of starvation mimics are considered promising therapeutics for common metabolic disorders, such as obesity, liver…”
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Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs by Johnson, Krystal C, Kilikevicius, Audrius, Hofman, Cristina, Hu, Jiaxin, Liu, Yang, Aguilar, Selina, Graswich, Jon, Han, Yi, Wang, Tao, Westcott, Jill M, Brekken, Rolf A, Peng, Lan, Karagkounis, Georgios, Corey, David R

“…Abstract Argonaute protein is associated with post-transcriptional control of cytoplasmic gene expression through miRNA-induced silencing complexes (miRISC)…”
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Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues by Sorrelle, Noah, Ganguly, Debolina, Dominguez, Adrian T A, Zhang, Yuqing, Huang, Huocong, Dahal, Lekh N, Burton, Natalie, Ziemys, Arturas, Brekken, Rolf A

“…Immune profiling of tissue through multiplex immunohistochemistry is important for the investigation of immune cell dynamics, and it can contribute to disease…”
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma by Aguilera, Kristina Y, Huang, Huocong, Du, Wenting, Hagopian, Moriah M, Wang, Zhen, Hinz, Stefan, Hwang, Tae Hyun, Wang, Huamin, Fleming, Jason B, Castrillon, Diego H, Ren, Xiaomei, Ding, Ke, Brekken, Rolf A

“…The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell…”
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Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and β2AR‐Dependent Neo‐Angiogenic Switch by Mulcrone, Patrick L, Campbell, J Preston, Clément‐Demange, Lise, Anbinder, Ana Lia, Merkel, Alyssa R, Brekken, Rolf A, Sterling, Julie A, Elefteriou, Florent

“…ABSTRACT The skeleton is a common site for breast cancer metastasis. Although significant progress has been made to manage osteolytic bone lesions, the…”
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