Search Results - "Brekke, Ole H."

Covalent antibody display—an in vitro antibody-DNA library selection system by Reiersen, Herald, Løbersli, Inger, Løset, Geir Å., Hvattum, Else, Simonsen, Bjørg, Stacy, John E., McGregor, Duncan, FitzGerald, Kevin, Welschof, Martin, Brekke, Ole H., Marvik, Ole J.

“…The endonuclease P2A initiates the DNA replication of the bacteriophage P2 by making a covalent bond with its own phosphate backbone. This enzyme has now been…”
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Lysine 322 in the human IgG3 CH2 domain is crucial for antibody dependent complement activation by Thommesen, John E, Michaelsen, Terje E, Løset, Geir Åge, Sandlie, Inger, Brekke, Ole H

“…The classical complement activation cascade of the immune system is initiated by multivalent binding of its first component, C1q, to the Fc region of…”
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Tailoring natural effector functions. Antibody engineering beyond humanization by Brekke, Ole H, Thommesen, John E

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One Disulfide Bond in Front of the Second Heavy Chain Constant Region is Necessary and Sufficient for Effector Functions of Human IgG3 Without a Genetic Hinge by Michaelsen, Terje E., Brekke, Ole H., Aase, Audun, Sandin, Randi H., Bremnes, Bjorn, Sandlie, Inger

“…We have created four IgG3 mutants without a normal hinge region: (i) m0 without a genetic hinge; (ii) m0/C131S, where Cys-131 in m0 was mutated to Ser; (iii)…”
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Identification and characterisation of C1q-binding phage displayed peptides by Lauvrak, V, Brekke, O H, Ihle, O, Lindqvist, B H

“…Five phage displayed peptide libraries were screened for binders to C1q, the recognition subunit of the classical complement pathway. Two rounds of panning…”
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Human IgG3 can adopt the disulfide bond pattern characteristic for IgG1 without resembling it in complement mediated cell lysis by Brekke, O H, Bremnes, B, Sandin, R, Aase, A, Michaelsen, T E, Sandlie, I

“…In this paper we describe the construction of mouse-human IgG3 mutant antibodies resembling IgG1 in their disulfide bond pattern between the heavy and light…”
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