Search Results - "Breitschopf, K"

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination by Staub, O., Gautschi, I., Ishikawa, T., Breitschopf, K., Ciechanover, A., Schild, L., Rotin, D.

“…The epithelial Na+ channel (ENaC), composed of three subunits (αβγ), plays a critical role in salt and fluid homeostasis. Abnormalities in channel opening and…”
Get full text

A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein by Breitschopf, Kristin, Bengal, Eyal, Ziv, Tamar, Admon, Arie, Ciechanover, Aaron

“…The ubiquitin proteolytic pathway is a major system for selective protein degradation in eukaryotic cells. One of the first steps in the degradation of a…”
Get full text

The exchange of the discriminator base A73 for G is alone sufficient to convert human tRNA(Leu) into a serine‐acceptor in vitro by Breitschopf, K., Gross, H.J.

“…Transfer RNA (tRNA) identify is maintained by the highly specific interaction of a few defined nucleotides or groups of nucleotides, called identity elements,…”
Get full text

Nitric Oxide Activates Telomerase and Delays Endothelial Cell Senescence by Vasa, Mariuca, Breitschopf, Kristin, Zeiher, Andreas M, Dimmeler, Stefanie

“…Endothelial cells (ECs) undergo a limited number of cell divisions, ultimately stop dividing, and enter a state that is designated replicative senescence…”
Get full text

Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction by Breitschopf, K, Zeiher, A M, Dimmeler, S

“…Under basal conditions, the proapoptotic protein Bid is a long-lived protein. Pro-apoptotic stimuli such as tumor necrosis factor-alpha (TNFalpha) or Fas…”
Get full text

Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway by Breitschopf, Kristin, Haendeler, Judith, Malchow, Philipp, Zeiher, Andreas M., Dimmeler, Stefanie

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism by Breitschopf, Kristin, Zeiher, Andreas M, Dimmeler, Stefanie

“…Advanced aging may contribute to impairment of angiogenesis and development of vascular diseases. Telomerase was shown to delay endothelial cell (EC)…”
Get full text

Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway by Dimmeler, S, Breitschopf, K, Haendeler, J, Zeiher, A M

“…Injury of the endothelial cells by the induction of apoptotic cell death may play an important role in the pathophysiology of atherosclerosis and the…”
Get full text

Nitric oxide inhibits caspase-3 by S-nitrosation in vivo by Rössig, L, Fichtlscherer, B, Breitschopf, K, Haendeler, J, Zeiher, A M, Mülsch, A, Dimmeler, S

“…In cultured human endothelial cells, physiological levels of NO prevent apoptosis and interfere with the activation of the caspase cascade. In vitro data have…”
Get full text

Degradation of Myogenic Transcription Factor MyoD by the Ubiquitin Pathway In Vivo and In Vitro: Regulation by Specific DNA Binding by Abu Hatoum, Ossama, Gross-Mesilaty, Shlomit, Breitschopf, Kristin, Hoffman, Aviad, Gonen, Hedva, Ciechanover, Aaron, Bengal, Eyal

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Identity elements of human tRNA(Leu): structural requirements for converting human tRNA(Ser) into a leucine acceptor in vitro by Breitschopf, K, Achsel, T, Busch, K, Gross, H J

“…We have previously shown that the exchange of the discriminator base A73 of human tRNA(Leu) for G is alone sufficient to achieve complete loss of leucine…”
Get full text

The discriminator bases G73 in human tRNA(Ser) and A73 in tRNA(Leu) have significantly different roles in the recognition of aminoacyl-tRNA synthetases by Breitschopf, K, Gross, H J

“…The recognition of human tRNA(Leu) or tRNA(Ser) by cognate aminoacyl- tRNA synthetases has distinct requirements. Only one base change (A73-->G) in tRNA(Leu)…”
Get full text

The exchange of the discriminator base A73 for G is alone sufficient to convert human tRNALeu into a serine-acceptor in vitro by BREITSCHOPF, K, GROSS, H. J

Get full text

The discriminator bases G73 in human tRNA super(Ser) and A73 in tRNA super(Leu) have significantly different roles in the recognition of aminoacyl-tRNA synthetases by Breitschopf, K, Gross, HJ

“…The recognition of human tRNA super(Leu) or tRNA super(Ser) by cognate aminoacyl-tRNA synthetases has distinct requirements. Only one base change (A73 arrow…”
Get full text

The exchange of the discriminator base A73 for G is alone sufficient to convert human tRNA super(Leu) into a serine-acceptor in vitro by Breitschopf, K, Gross, HJ

“…Transfer RNA (tRNA) identity is maintained by the highly specific interaction of a few defined nucleotides or groups of nucleotides, called identity elements,…”
Get full text

The Discriminator Bases G73 in Human tRNASer and A73 in tRNALeu Have Significantly Different Roles in the Recognition of Aminoacyl-tRNA Synthetases by Breitschopf, Kristin, Gross, Hans J.

“…The recognition of human tRNALeu or tRNASer by cognate aminoacyl-tRNA synthetases has distinct requirements. Only one base change (A73→G) in tRNALeu is…”
Get full text

Regulation of stability and function of the epithelial Na super(+) channel (ENaC) by ubiquitination by Staub, O, Gautschi, I, Ishikawa, T, Breitschopf, K, Ciechanover, A, Schild, L, Rotin, D

“…The epithelial Na super(+) channel (ENaC), composed of three subunits ( alpha beta gamma ), plays a critical role in salt and fluid homeostasis. Abnormalities…”
Get full text

Degradation of MyoD by the ubiquitin pathway: regulation by specific DNA-binding and identification of a novel site for ubiquitination by Ciechanover, A, Breitschopf, K, Hatoum, O A, Bengal, E

“…MyoD is a tissue-specific transcriptional activator involvd in skeletal muscle differentiation. It is induced during transition from proliferating,…”
Get full text

Identity elements of human tRNA super(Leu): Structural requirements for converting human tRNA super(Ser) into a leucine acceptor in vitro by Breitschopf, K, Achsel, T, Busch, K, Gross, HJ

“…We have previously shown that the exchange of the discriminator base A73 of human tRNA super(Leu) for G is alone sufficient to achieve complete loss of leucine…”
Get full text

Structural studies on tRNA acceptor stem microhelices: Exchange of the discriminator base A73 for G in human tRNA super(Leu) switches the acceptor specificity from leucine to serine possibly by decreasing the stability of the terminal G1-C72 base pair by Metzger, A U, Heckl, M, Willbold, D, Breitschopf, K, RajBhandary, U L, Roesch, P, Gross, HJ

“…Correct recognition of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (aaRS) is crucial to the maintenance of translational fidelity. The discriminator…”
Get full text