Search Results - "Breitman, Martin"

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium by Fong, Guo-Hua, Rossant, Janet, Gertsenstein, Marina, Breitman, Martin L

“…The vascular endothelial growth factor (VEGF) and its high-affinity binding receptors, the tyrosine kinases Flt-1 and Flk-1, are thought to be important for…”
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Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3 by Dumont, Daniel J., Jussila, Lotta, Taipale, Jussi, Lymboussaki, Athina, Mustonen, Tuija, Pajusola, Katri, Breitman, Martin, Alitalo, Kari

“…Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related…”
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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice by Shalaby, Fouad, Rossant, Janet, Yamaguchi, Terry P, Gertsenstein, Marina, Wu, Xiang-Fu, Breitman, Martin L, Schuh, Andre C

“…The receptor tyrosine kinase Flk-1 (ref. 1) is believed to play a pivotal role in endothelial development. Expression of the Flk-1 receptor is restricted to…”
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Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development by Dumont, Daniel J., Fong, Guo‐Hua, Puri, Mira C., Gradwohl, Gérard, Alitalo, Kari, Breitman, Martin L.

“…We report the detailed developmental expression profiles of three endothelial specific receptor tyrosine kinases (RTKs) flk‐1, tek, tie, as well as vascular…”
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beta $1-6 Branching of Asn-Linked Oligosaccharides is Directly Associated with Metastasis by Dennis, James W., Laferté, Suzanne, Waghorne, Carol, Breitman, Martin L., Kerbel, Robert S.

“…Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and $\beta…”
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flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors by YAMAGUCHI, T. P, DUMONT, D. J, CONLON, R. A, BREITMAN, M. L, ROSSANT, J

“…We have used RT-PCR to screen pluripotent murine embryonic stem cells to identify receptor tyrosine kinases (RTKs) potentially involved in the determination or…”
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A frameshift mutation in the γE-crystallin gene of the Elo mouse by Breitman, Martin L, Tsui, Lap-Chee, Cartier, Mireille

“…The murine Elo (eye lens obsolescence) mutation confers a dominant phenotype characterized by malformation of the eye lens. The mutation maps to chromosome 1,…”
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Genetic Ablation: Targeted Expression of a Toxin Gene Causes Microphthalmia in Transgenic Mice by Breitman, Martin L., Clapoff, Susan, Rossant, Janet, Tsui, Lap-Chee, Glode, L. Michael, Maxwell, Ian H., Bernstein, Alan

“…Lineage-specific regulatory elements can be used to direct expression of a variety of genes to specific tissues in transgenic mice. If the hybrid constructs…”
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Obligatory wounding requirement for tumorigenesis in v- jun transgenic mice by Schuh, Andre C, Keating, Sarah J, Monteclaro, Felipe S, Vogt, Peter K, Breitman, Martin L

“…Avian sarcoma virus 17 induces fibrosarcomas in chickens and can transform a number of avian cell types in vitro by the action of v-jun. This gene and the…”
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A Model for Spontaneous B-Lineage Lymphomas in IgHμ-HOX11 Transgenic Mice by Hough, Margaret R., Reis, Marciano D., Singaraja, Roshni, Bryce, Dawn Marie, Kamel-Reid, Suzanne, Dardick, Irving, Breitman, Martin L., Dube, Ian D.

“…HOX11, a divergent homeodomain-containing transcription factor, was isolated from the breakpoint of the nonrandom t(10;14) (q24;q11) chromosome translocation…”
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Expression of the Fms-Like Tyrosine Kinase 4 Gene Becomes Restricted to Lymphatic Endothelium During Development by Kaipainen, Arja, Korhonen, Jaana, Mustonen, Tuija, Victor W. M. van Hinsbergh, Fang, Guo-Hua, Dumont, Daniel, Breitman, Martin, Alitalo, Kari

“…We have recently cloned the human fms-like tyrosine kinase 4 gene FLT4, whose protein product is related to two vascular endothelial growth factor receptors…”
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Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo by Dumont, D J, Gradwohl, G, Fong, G H, Puri, M C, Gertsenstein, M, Auerbach, A, Breitman, M L

“…The receptor tyrosine kinases (RTKs) expressed on the surface of endothelial cells are likely to play key roles in initiating the program of endothelial cell…”
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Regulation offlt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium by Fong, Guo-Hua, Klingensmith, John, Wood, Clive R., Rossant, Janet, Breitman, Martin L.

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Analysis of lens cell fate and eye morphogenesis in transgenic mice ablated for cells of the lens lineage by Breitman, M L, Bryce, D M, Giddens, E, Clapoff, S, Goring, D, Tsui, L C, Klintworth, G K, Bernstein, A

“…Transgenic mice carrying the diphtheria toxin A gene driven by mouse gamma 2-crystallin promoter sequences manifest microphthalmia due to ablation of fiber…”
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tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors by Dumont, D J, Yamaguchi, T P, Conlon, R A, Rossant, J, Breitman, M L

“…A search for protein tyrosine kinases expressed during murine cardiogenesis resulted in the isolation of a novel tyrosine kinase, designated tek, which maps to…”
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β1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis by DENNIS, J. W, LAFERTE, S, WAGHORNE, C, BREITMAN, M. L, KERBEL, R. S

“…Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and…”
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The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development by Tang, S J, Hoodless, P A, Lu, Z, Breitman, M L, McInnes, R R, Wrana, J L, Buchwald, M

“…TGFbeta-related factors are critical regulators of vertebrate mesoderm development. However, the signalling cascades required for their function during this…”
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Regulation of flt‐1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium by Fong, Guo‐Hua, Klingensmith, John, Wood, Clive R., Rossant, Janet, Breitman, Martin L.

“…Flt‐1 is a high affinity binding receptor for the vascular endothelial cell growth factor (VEGF) and is primarily expressed in endothelial cells. In this study…”
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The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors by Dumont, D J, Gradwohl, G J, Fong, G H, Auerbach, R, Breitman, M L

“…We have cloned a 4.2-kb murine cDNA encoding the Tek receptor tyrosine kinase (RTK), which is expressed in endothelial cells and their progenitors. The…”
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An everted repeat mediates retinoic acid induction of the γF-crystallin gene : evidence of a direct role for retinoids in lens development by TINI, M, OTULAKOWSKI, G, BREITMAN, LAP-CHEE TSUI, GIGUERE, V

“…The vertebrate lens is a classical system for examining mechanisms of tissue determination and differentiation, yet little is known about the signaling…”
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