Search Results - "Breitenbach, Julie M."

Design and synthesis of vidarabine prodrugs as antiviral agents by Shen, Wei, Kim, Jae-Seung, Kish, Phillip E., Zhang, Jie, Mitchell, Stefanie, Gentry, Brian G., Breitenbach, Julie M., Drach, John C., Hilfinger, John

“…The synthesis of vidarabine prodrugs and their antiviral activities is reported. 5′- O- d- and l-amino acid derivatives and 5′- O-( d- and l-amino acid methyl…”
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Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir by Eriksson, Ulrika, Hilfinger, John M., Kim, Jae-Seung, Mitchell, Stefanie, Kijek, Paul, Borysko, Katherine Z., Breitenbach, Julie M., Drach, John C., Kashemirov, Boris A., McKenna, Charles E.

“…The synthesis, biological activation and oral bioavailability of an ethylene glycol-linked L-valyl ester conjugate of cyclic cidofovir ( 3) is reported…”
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Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo by Lorenzi, Philip L, Landowski, Christopher P, Song, Xueqin, Borysko, Katherine Z, Breitenbach, Julie M, Kim, Jae Seung, Hilfinger, John M, Townsend, Leroy B, Drach, John C, Amidon, Gordon L

“…2-Bromo-5,6-dichloro-1-(beta-d-ribofuranosyl)benzimidazole (BDCRB) is a potent and selective inhibitor of human cytomegalovirus (HCMV), but it lacks clinical…”
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Tyrosine-Based 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) Prodrugs: Synthesis, Stability, Antiviral Activity, and in Vivo Transport Studies by Zakharova, Valeria M, Serpi, Michaela, Krylov, Ivan S, Peterson, Larryn W, Breitenbach, Julie M, Borysko, Katherine Z, Drach, John C, Collins, Mindy, Hilfinger, John M, Kashemirov, Boris A, McKenna, Charles E

“…Eight novel single amino acid (6–11) and dipeptide (12, 13) tyrosine P–O esters of cyclic cidofovir ((S)-cHPMPC, 4) and its cyclic adenine analogue…”
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Inhibition of Cyclin-Dependent Kinase 1 by Purines and Pyrrolo[2,3-d]Pyrimidines Does Not Correlate with Antiviral Activity by EVERS, David L, BREITENBACH, Julie M, BORYSKO, Katherine Z, TOWNSEND, Leroy B, DRACHL, John C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89 by Gentry, Brian G, Phan, Quang, Hall, Ellie D, Breitenbach, Julie M, Borysko, Katherine Z, Kamil, Jeremy P, Townsend, Leroy B, Drach, John C

“…Human cytomegalovirus (HCMV) infection can cause severe illnesses, including encephalopathy and mental retardation, in immunocompromised and immunologically…”
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Synthesis and Antiviral Activity of (Z)- and (E)-2,2-[Bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines:  Second-Generation Methylenecyclopropane Analogues of Nucleosides by Zhou, Shaoman, Breitenbach, Julie M, Borysko, Katherine Z, Drach, John C, Kern, Earl R, Gullen, Elizabeth, Cheng, Yung-Chi, Zemlicka, Jiri

“…The second generation of methylenecyclopropane analogues of nucleosides 5a − 5i and 6a − 6i was synthesized and evaluated for antiviral activity. The…”
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Benzimidazole Ribonucleosides: Design, Synthesis, and Antiviral Activity of Certain 2-(Alkylthio)- and 2-(Benzylthio)-5,6-dichloro-1-(.beta.-D-ribofuranosyl)benzimidazoles by Devivar, Rodrigo V, Kawashima, Etsuko, Revankar, Ganapathi R, Breitenbach, Julie M, Kreske, Edward D, Drach, John C, Townsend, Leroy B

“…Several 2-alkylthio- and 2-benzylthio derivatives of 5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole (DRB) have been designed and synthesized from…”
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Nonnucleoside Pyrrolopyrimidines with a Unique Mechanism of Action against Human Cytomegalovirus by JACOBSON, J. G, RENAU, T. E, NASSIRI, M. R, SWEIER, D. G, BREITENBACH, J. M, TOWNSEND, L. B, DRACH, J. C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Serine Peptide Phosphoester Prodrugs of Cyclic Cidofovir: Synthesis, Transport, and Antiviral Activity by Eriksson, Ulrika, Peterson, Larryn W, Kashemirov, Boris A, Hilfinger, John M, Drach, John C, Borysko, Katherine Z, Breitenbach, Julie M, Kim, Jae Seung, Mitchell, Stefanie, Kijek, Paul, McKenna, Charles E

“…Cidofovir (HPMPC, 1), a broad-spectrum antiviral agent, is currently used to treat AIDS-related human cytomegalovirus (HCMV) retinitis and has recognized…”
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(Z)- and (E)-2-((Hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New Nucleoside Analogues with a Broad-Spectrum Antiviral Activity by Qiu, Yao-Ling, Ksebati, Mohamad B, Ptak, Roger G, Fan, Boreas Y, Breitenbach, Julie M, Lin, Ju-Sheng, Cheng, Yung-Chi, Kern, Earl R, Drach, John C, Zemlicka, Jiri

“…New nucleoside analogues 14−17 based on a methylenecyclopropane structure were synthesized and evaluated for antiviral activity. Reaction of 2,3-dibromopropene…”
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(R)-(−)- and (S)-(+)-Synadenol:  Synthesis, Absolute Configuration, and Enantioselectivity of Antiviral Effect by Qiu, Yao-Ling, Hempel, Andrew, Camerman, Norman, Camerman, Arthur, Geiser, Fiona, Ptak, Roger G, Breitenbach, Julie M, Kira, Toshiko, Li, Ling, Gullen, Elizabeth, Cheng, Yung-Chi, Drach, John C, Zemlicka, Jiri

“…Synthesis of (R)-(−)- and (S)-(+)-synadenol (1a and 2a, 95−96% ee) is described. Racemic synadenol (1a + 2a) was deaminated with adenosine deaminase to give…”
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Deoxy Sugar Analogues of Triciribine:  Correlation of Antiviral and Antiproliferative Activity with Intracellular Phosphorylation by Porcari, Anthony R, Ptak, Roger G, Borysko, Katherine Z, Breitenbach, Julie M, Vittori, Sauro, Wotring, Linda L, Drach, John C, Townsend, Leroy B

“…Triciribine (TCN) and triciribine monophosphate (TCN-P) have antiviral and antineoplastic activity at low micromolar or submicromolar concentrations. In an…”
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Synthesis of Non-nucleoside Analogs of Toyocamycin, Sangivamycin, and Thiosangivamycin:  The Effect of Certain 4- and 4,6-Substituents on the Antiviral Activity of Pyrrolo[2,3-d]pyrimidines by Renau, Thomas E, Kennedy, Christopher, Ptak, Roger G, Breitenbach, Julie M, Drach, John C, Townsend, Leroy B

“…A number of 4-substituted 7-(ethoxymethyl)- and 7-[(2-methoxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile and -5-thiocarboxamide derivatives and…”
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Synthesis and Antiviral Activity of 2-Substituted Analogs of Triciribine by Porcari, Anthony R., Ptak‡, Roger G., Borysko, Katherine Z., Breitenbach, Julie M., Drach, John C., Townsend, Leroy B.

“…Triciribine (TCN) and triciribine monophosphate (TCN-P) have antiviral and antineoplastic activity at low or submicromolar concentrations. In an effort to…”
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6-N-Acyltriciribine Analogues:  Structure−Activity Relationship between Acyl Carbon Chain Length and Activity against HIV-1 by Porcari, Anthony R, Ptak, Roger G, Borysko, Katherine Z, Breitenbach, Julie M, Drach, John C, Townsend, Leroy B

“…Triciribine (TCN) and triciribine-5‘-monophosphate (TCN-P) are active against HIV-1 at submicromolar concentrations. In an effort to improve and better…”
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Studies on Anti-HSV Activity and Cytotoxicity of Morinda citrifolia L. Noni Leaf by Selvam, Periyasamy, Breitenbach, Julie M., Borysko, Katherine Z., Drach, John C.

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Synthesis, Antiviral Activity, and Cytotoxicity of Some Novel 2-Phenyl-3-disubstituted Quinazolin-4(3H)-ones by Selvam, Periyasamy, Breitenbach, Julie M., Borysko, Katherine Z., Drach, John C.

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Synthesis and Activity of Vidarabine d-Amino Acid Prodrugs as Potential Pox Virus Agents by Breitenbach, Julie M., Shen, Wei, Hilfinger, John, Drach, John C.

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Resistance of Human Cytomegalovirus to Cyclopropavir Involves a Novel Mutation in UL97 by Borysko, Katherine Z., Gentry, Brian G., Breitenbach, Julie M., Zemlicka, Jiri, Drach, John C.

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