Search Results - "Breimer, Gerben E"

Sinonasal Squamous Cell Carcinoma in the Netherlands: A Population-Based Study of 568 Cases Diagnosed in 2008-2021 by van de Velde, Lise J, Scheurleer, W F Julius, Braunius, W Weibel, Speksnijder, Caroline M, de Ridder, Mischa, Devriese, Lot A, de Bree, Remco, Breimer, Gerben E, Rijken, Johannes A, van Dijk, Boukje A C

“…Sinonasal squamous cell carcinoma is known for its rarity and poor prognosis. This study aims to investigate the trends in the incidence of sinonasal squamous…”
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Deep learning-based classification of kidney transplant pathology: a retrospective, multicentre, proof-of-concept study by Kers, Jesper, Bülow, Roman D, Klinkhammer, Barbara M, Breimer, Gerben E, Fontana, Francesco, Abiola, Adeyemi Adefidipe, Hofstraat, Rianne, Corthals, Garry L, Peters-Sengers, Hessel, Djudjaj, Sonja, von Stillfried, Saskia, Hölscher, David L, Pieters, Tobias T, van Zuilen, Arjan D, Bemelman, Frederike J, Nurmohamed, Azam S, Naesens, Maarten, Roelofs, Joris J T H, Florquin, Sandrine, Floege, Jürgen, Nguyen, Tri Q, Kather, Jakob N, Boor, Peter

“…Histopathological assessment of transplant biopsies is currently the standard method to diagnose allograft rejection and can help guide patient management, but…”
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Spatial correlation between in vivo imaging and immunohistochemical biomarkers: A methodological study by Smits, Hilde J.G., Bennink, Edwin, Ruiter, Lilian N., Breimer, Gerben E., Willems, Stefan M., Dankbaar, Jan W., Philippens, Marielle E.P.

“…•We present a unique method of correlating in vivo imaging to immunohistochemistry.•3D heatmaps of biomarker presence are created from whole-mount tumor…”
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Implementation of Artificial Intelligence in Diagnostic Practice as a Next Step after Going Digital: The UMC Utrecht Perspective by Flach, Rachel N, Fransen, Nina L, Sonnen, Andreas F P, Nguyen, Tri Q, Breimer, Gerben E, Veta, Mitko, Stathonikos, Nikolas, van Dooijeweert, Carmen, van Diest, Paul J

“…Building on a growing number of pathology labs having a full digital infrastructure for pathology diagnostics, there is a growing interest in implementing…”
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Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases by Scheurleer, W. F. Julius, Braunius, Weibel W., Tijink, Bernard M., Janssen, Luuk M., Pameijer, Frank A., Breimer, Gerben E., Smid, Ernst J., de Bree, Remco, Devriese, Lot A., Rijken, Johannes A.

“…Background. Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior…”
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Validation of automated positive cell and region detection of immunohistochemically stained laryngeal tumor tissue using digital image analysis by Smits, Hilde J.G., Swartz, Justin E., Philippens, Marielle E.P., de Bree, Remco, Kaanders, Johannes H.A.M., Koppes, Sjors A., Breimer, Gerben E., Willems, Stefan M.

“…This study aimed to validate a digital image analysis (DIA) workflow for automatic positive cell detection and positive region delineation for…”
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A phase Ib/II study of regorafenib and paclitaxel in patients with beyond first-line advanced esophagogastric carcinoma (REPEAT) by Stroes, Charlotte I, Schokker, Sandor, Khurshed, Mohammed, van der Woude, Stephanie O, Mathôt, Ron AA, Slingerland, Marije, de Vos-Geelen, Judith, Zucchetti, Massimo, Matteo, Cristina, van Dijk, Erik, Ylstra, Bauke, Thijssen, Victor, Derks, Sarah, Godefa, Tesfay, Dijksterhuis, Willemieke, Breimer, Gerben E, van Delden, Otto M, Verhoeven, Rob HA, Meijer, Sybren L, Bijlsma, Maarten F, van Laarhoven, Hanneke WM

“…Purpose: Regorafenib monotherapy, a multikinase inhibitor of angiogenesis, tumor microenvironment, and tumorigenesis, showed promising results in gastric…”
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Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer by Haughton, Peter D., Haakma, Wisse, Chalkiadakis, Theofilos, Breimer, Gerben E., Driehuis, Else, Clevers, Hans, Willems, Stefan, Prekovic, Stefan, Derksen, Patrick W. B.

“…Clinical outcome for patients suffering from HPV-negative head and neck squamous cell carcinoma (HNSCC) remains poor. This is mostly due to highly invasive…”
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Development and evaluation of a patient-specific surgical simulator for endoscopic colloid cyst resection by Bodani, Vivek P, Breimer, Gerben E, Haji, Faizal A, Looi, Thomas, Drake, James M

“…Endoscopic resection of third-ventricle colloid cysts is technically challenging due to the limited dexterity and visualization provided by neuroendoscopic…”
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Using Intratumor Heterogeneity of Immunohistochemistry Biomarkers to Classify Laryngeal and Hypopharyngeal Tumors Based on Histologic Features by Smits, Hilde J.G., Ruiter, Lilian N., Breimer, Gerben E., Willems, Stefan M., Philippens, Marielle E.P.

“…Haralick texture features are used to quantify the spatial distribution of signal intensities within an image. In this study, the heterogeneity of…”
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The prognostic role of tumor associated macrophages in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis by Bisheshar, Sangeeta K., van der Kamp, Martine F., de Ruiter, Emma J., Ruiter, Lilian N., van der Vegt, Bert, Breimer, Gerben E., Willems, Stefan M.

“…•This comprehensive systematic review and meta-analysis fulfill an unmet need by deciphering the prognostic role of Tumor Associated Macrophage (TAM) markers…”
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Application and accuracy of ultrasound-guided resections of tongue cancer by de Koning, Klijs J., van Es, Robert J.J., Klijn, Reinoud J., Breimer, Gerben E., Willem Dankbaar, Jan, Braunius, Weibel W., van Cann, Ellen M., Dieleman, François J., Rijken, Johannes A., Tijink, Bernard M., de Bree, Remco, Noorlag, Rob

“…•Ultrasound provides good overview of the tongue tumour's extent and deep margin.•Ultrasound-guided surgery leads to a significant increase in free margin…”
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Design and evaluation of a new synthetic brain simulator for endoscopic third ventriculostomy by Breimer, Gerben E, Bodani, Vivek, Looi, Thomas, Drake, James M

“…Endoscopic third ventriculostomy (ETV) is an effective but technically demanding procedure with significant risk. Current simulators, including human cadavers,…”
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Surgical margins in the resection of oral squamous cell carcinoma under local versus general anesthesia by van Munster, Meeke H., de Bree, Remco, Breimer, Gerben E., Van Cann, Ellen M.

“…•Removal of oral cancer is safer under general than under local anesthesia.•Tumor resection under general anesthesia is associated with more clean margins…”
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MYB immunohistochemistry as a predictor of MYB::NFIB fusion in the diagnosis of adenoid cystic carcinoma of the head and neck by Klein Nulent, Thomas J.W., van Es, Robert J.J., Breimer, Gerben E., Valstar, Matthijs H., Smit, Laura A., Speksnijder, Caroline M., de Bree, Remco, Willems, Stefan M.

“…Diagnosing adenoid cystic carcinoma (AdCC) is challenging due to histopathological variability and similarities with other tumors. In AdCC pathogenesis, the…”
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Pros and cons of artificial intelligence implementation in diagnostic pathology by Diest, Paul J, Flach, Rachel N, Dooijeweert, Carmen, Makineli, Seher, Breimer, Gerben E, Stathonikos, Nikolas, Pham, Paul, Nguyen, Tri Q, Veta, Mitko

“…The rapid introduction of digital pathology has greatly facilitated development of artificial intelligence (AI) models in pathology that have shown great…”
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Ultrasound‐guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study by Adriaansens, Carleen M. E. M., Koning, Klijs J., Bree, Remco, Dankbaar, Jan Willem, Breimer, Gerben E., Es, Robert J. J., Noorlag, Rob

“…Background Image‐guided surgery could help obtain clear (≥5.0 mm) resection margins. This feasibility study investigated ultrasound‐guided resection accuracy…”
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FGFR3::TACC3 fusions in head and neck carcinomas: a study of nine cases highlighting phenotypic heterogeneity, frequent HPV association, and a morphologically distinct subset in favor of a putative entity by Agaimy, Abbas, Antonescu, Cristina R, Bell, Diana, Breimer, Gerben E, Dermawan, Josephine K, Kester, Lennart A, Laco, Jan, Rijken, Johannes A, Whaley, Rumeal D, Stoehr, Robert, Cramer, Thomas, Bishop, Justin A

“…The FGFR3::TACC3 fusion has been reported in subsets of diverse cancers including urothelial and squamous cell carcinomas (SCC). However, the morphology of…”
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Extra-abdominal and intra-abdominal FET::CREM fusion mesenchymal neoplasms: comparative clinicopathological study of 9 new cases further supporting a distinct potentially aggressive sarcoma and report of novel sites by Agaimy, Abbas, Blakely, Morgan, Breimer, Gerben E, Hölsken, Annett, Koppes, Sjors A, Meidenbauer, Norbert, Rijken, Johannes A, Schad, Arno, Simon, Adrian G, Stoehr, Robert, Bishop, Justin A, Din, Nasir Ud

“…With the wide use of RNA sequencing technologies, the family of FET::CREB fusion mesenchymal neoplasms has expanded rapidly to include potentially aggressive…”
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Comparative Performance Analysis of Idylla and Archer in the Detection of Gene Fusions in Spitzoid Melanocytic Tumors by Ebbelaar, Chiel F., van Dijk, Marijke, Breimer, Gerben E., Meijers, Ruud W.J., Klein, Laura B.C., Petronilia, Maryleen M., de Leng, Wendy W.J., Blokx, Willeke A.M., Jansen, Anne M.L.

“…Melanocytic neoplasms with spitzoid histomorphology are often difficult to classify without identifying genetic drivers such as kinase fusions. Traditional…”
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