Search Results - "Breeze, A. L."

Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase by Booker, Grant W, Breeze, Alexander L, Downing, A. Kristina, Panayotou, George, Gout, Ivan, Waterfield, Michael D, Campbell, Iain D

“…Receptor protein-tyrosine kinases, through phosphorylation of specific tyrosine residues, generate high-affinity binding sites which direct assembly of…”
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Structure of a specific peptide complex of the carboxy‐terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3‐kinase by Breeze, A. L., Kara, B. V., Barratt, D. G., Anderson, M., Smith, J. C., Luke, R. W., Best, J. R., Cartlidge, S. A.

“…We have determined the solution structure of the C‐terminal SH2 domain of the p85 alpha subunit of human phosphatidylinositol (PI) 3‐kinase (EC 2.7.1.137) in…”
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The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin by Tsai, Francis T.F., Singh, Onkar M.P., Skarzynski, Tadeusz, Wonacott, Alan J., Weston, Simon, Tucker, Alec, Pauptit, Richard A., Breeze, Alexander L., Poyser, J. Philip, O'Brien, Ronan, Ladbury, John E., Wigley, Dale B.

“…Coumarin antibiotics, such as clorobiocin, novobiocin, and coumermycin A1, inhibit the supercoiling activity of gyrase by binding to the gyrase B (GyrB)…”
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Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain by Black, A R, Breeze, A L, Othman, I B, Dolly, J O

“…Dendrotoxin, a snake-venom polypeptide, is a potent convulsant that facilitates transmitter release apparently by inhibition of voltage-sensitive K+ channels…”
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Identification by cross-linking of a neuronal acceptor protein for dendrotoxin, a convulsant polypeptide by Mehraban, Fuad, Breeze, Alexander L., Dolly, J.Oliver

“…Dendrotoxin, a lijow molecular weight protein from the venom of Dendroaspis angusticeps, is known to be a potent convulsant that attenuates one type of…”
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Interactions between discrete neuronal membrane binding sites for the putative K+‐channel ligands β‐bungarotoxin, dendrotoxin and mast‐cell‐degranulating peptide by BREEZE, Alexander L., DOLLY, J. Oliver

“…1 β‐Bungarotoxin, a presynaptically active neurotoxin from the venom of Bungarus multicinctus, was radiolabelled with 125I and its binding to synaptic…”
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Secondary Structure and Backbone Dynamics of Human Granulocyte Colony-Stimulating Factor in Solution by Werner, Jorn M, Breeze, Alexander L, Kara, Bo, Rosenbrock, Gina, Boyd, Jonathan, Soffe, Nick, Campbell, Iain D

“…The secondary structure and backbone dynamics of the cytokine, human granulocyte colony-stimulating factor (hG-CSF) have been determined by heteronuclear…”
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Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics by BREEZE, A. L, HARVEY, T. S, BAZZO, R, CAMPBELL, I. D

“…The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by 1H NMR in a mixed-solvent system of 50% trifluoroethanol/50% H2O at…”
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Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release by Dolly, J O, Halliwell, J V, Black, J D, Williams, R S, Pelchen-Matthews, A, Breeze, A L, Mehraban, F, Othman, I B, Black, A R

“…Acceptors for BoNT have been detected autoradiographically on the terminal membrane of motor nerves at a density of approximately 150/micron2 and shown to…”
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Isotope-filtered NMR methods for the study of biomolecular structure and interactions by Breeze, Alexander L.

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Prevention of MKK6-Dependent Activation by Binding to p38α MAP Kinase by Sullivan, Jane E, Holdgate, Geoffrey A, Campbell, Douglas, Timms, David, Gerhardt, Stefan, Breed, Jason, Breeze, Alexander L, Bermingham, Alun, Pauptit, Richard A, Norman, Richard A, Embrey, Kevin J, Read, Jon, VanScyoc, Wendy S, Ward, Walter H. J

“…Inhibition of p38α MAP kinase is a potential approach for the treatment of inflammatory disorders. MKK6-dependent phosphorylation on the activation loop of…”
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Structure-based design of protein tyrosine phosphatase-1B inhibitors by Black, Emma, Breed, Jason, Breeze, Alexander L., Embrey, Kevin, Garcia, Robert, Gero, Thomas W., Godfrey, Linda, Kenny, Peter W., Morley, Andrew D., Minshull, Claire A., Pannifer, Andrew D., Read, Jon, Rees, Amanda, Russell, Daniel J., Toader, Dorin, Tucker, Julie

“…Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the…”
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NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex by Pauptit, R A, Dennis, C A, Derbyshire, D J, Breeze, A L, Weston, S A, Rowsell, S, Murshudov, G N

“…Two cases of successful molecular replacement using NMR trial models are presented. One is the crystal structure of the Escherichia coli colicin immunity…”
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NMR trial models: experiences with the colicin immunity protein Im7 and the p85α C-terminal SH2-peptide complex by Pauptit, Richard A., Dennis, Caitríona A., Derbyshire, Dean J., Breeze, Alexander L., Weston, Simon A., Rowsell, Siân, Murshudov, Garib N.

“…Two cases of successful molecular replacement using NMR trial models are presented. One is the crystal structure of the Escherichia coli colicin immunity…”
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Three-Dimensional Solution Structure and 13C Nuclear Magnetic Resonance Assignments of the Colicin E9 Immunity Protein Im9 by Osborne, Michael J, Breeze, Alexander L, Lian, Lu-Yun, Reilly, Ann, James, Richard, Kleanthous, Colin, Moore, Geoffrey R

“…The 86-amino acid colicin E9 immunity protein (Im9), which inhibits the DNase activity of colicin E9, has been overexpressed in Escherichia coli and…”
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Three-dimensional solution structure and super(13)C nuclear magnetic resonance assignments of the colicin E9 immunity protein Im9 by Osborne, MJ, Breeze, AL, Lian, Lu-Yun, Reilly, A, James, R, Kleanthous, C, Moore, G R

“…The 86-amino acid colicin E9 immunity protein (Im9), which inhibits the DNase activity of colicin E9, has been overexpressed in Escherichia coli and…”
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Interactions between discrete neuronal membrane binding sites for the putative K super(+)-channel ligands beta -bungarotoxin, dendrotoxin and mast cell-degranulating peptide by Breeze, AL, Dolly, JO

“…beta -Bungarotoxin, a presynaptically active neurotoxin from the venom of Bungarus multicinctus , was radiolabelled with super(125)I and its binding to…”
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